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| 乙型肝炎病毒x蛋白在HBV宫内感染中的作用 | |
| 引用本文： | 白桂芹,张凌燕,付逢萍,唐瑶.乙型肝炎病毒x蛋白在HBV宫内感染中的作用[J].西安交通大学学报(医学版),2011,32(5):615-618. |
| 作者姓名： | 白桂芹 张凌燕 付逢萍 唐瑶 |
| 作者单位： | 1. 西安交通大学医学院第一附属医院妇产科,陕西西安,710061 2. 陕西省人民医院妇产科,陕西西安,710068 3. 西安交通大学医学院,陕西西安,710061 |
| 摘 要： | 目的研究HBV(hepatitis B virus)感染胎盘和正常胎盘在HBxAg(hepatitis B x antigen)蛋白表达上的不同,探讨HBxAg在HBV宫内感染中可能发挥的作用。方法选择24例已证实发生宫内感染的HBsAg(hepatitis Bsurface antigen)阳性孕妇(感染组)和10例正常健康孕妇(对照组)的胎盘组织,应用免疫组织化学SP染色法,检测各组胎盘中HBxAg的表达,用TUNEL法检测细胞凋亡情况。结果在HBV感染组的胎盘中可检测到HBxAg的表达,且高复制组(HBV DNA>1×103拷贝/mL)染色吸光度值明显高于低复制组(HBV DNA<1×103拷贝/mL),差异有统计学意义(P<0.05);HBV感染高复制组细胞凋亡指数低于低复制组和对照组,差异有统计学意义(P<0.01)。结论 HBxAg/抗细胞凋亡是HBV DNA高复制孕妇发生宫内感染的可能机制,而HBV DNA阴性孕妇存在不同的作用机制。 |
| 关 键 词： | 乙型肝炎病毒x蛋白(HBxAg) 细胞凋亡 宫内感染 |
Role of hepatitis B virus x protein in intrauterine infection |
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| BAI Gui-qin,ZHANG Ling-yan,FU Feng-ping,TANG Yao.Role of hepatitis B virus x protein in intrauterine infection[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2011,32(5):615-618. | |
| Authors: | BAI Gui-qin ZHANG Ling-yan FU Feng-ping TANG Yao |
| Institution: | BAI Gui-qin1,ZHANG Ling-yan2,FU Feng-ping3,TANG Yao3(1.Department of Gynecology and Obstetrics,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710061,2.Department ofGynecology and Obstetrics,Shaanxi Provincial People's Hospital,Xi'an 710068,3.Medical School of Xi'an Jiaotong University,China) |
| Abstract: | Objective To study the difference of hepatitis B x antigen(HBxAg) expression level in hepatitis B virus(HBV)-infected placenta and normal placenta and then discuss the possible role of HBxAg in intrauterine infection.Methods We selected 24 full-term pregnant women who had been verified with intrauterine infection hepatitis B surface antigen(HBsAg) positive] as the infected group and 10 normal full-term pregnant women as the control group.We used immunohistochemical staining method(SP staining method) to te... |
| Keywords: | hepatitis B x antigen(HbxAg) cell apoptosis intrauterine infection |
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