| 他扎罗汀对银屑病增殖表皮中肝素结合表皮生长因子样生长因子基因的调节作用 |
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| 引用本文： | 郑焱,谭升顺,彭振辉,郗彦萍.他扎罗汀对银屑病增殖表皮中肝素结合表皮生长因子样生长因子基因的调节作用[J].西安交通大学学报(医学版),2005,26(1):80-82. |
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| 作者姓名： | 郑焱 谭升顺 彭振辉 郗彦萍 |
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| 作者单位： | 西安交通大学第二医院皮肤科,陕西,西安,710004 |
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| 基金项目： | 国家自然科学基金资助项目(No. 30070699) |
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| 摘 要： | 目的 探讨他扎罗汀在进行期寻常型银屑病中的作用机制。方法 用原位杂交的方法检测进行期银屑病皮损用药前后的肝素结合表皮生长因子样生长因子(HB- EGF)mRNA的表达。结果 在银屑病皮损中,全层几乎无 HB- EGF mRNA的表达(9.1%),他扎罗汀治疗后10 d可见HB -EGF不仅表达于基底层(95.5%),且以灶状表达于基底上层(77.3%)。结论 他扎罗汀通过上调银屑病表皮中HB- EGF的表达抑制表皮角质形成细胞的增殖,并诱导其凋亡。
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| 关 键 词： | HB-EGF 他扎罗汀 银屑病 |
| 文章编号： | 1671-8259(2005)01-0080-03 |
| 修稿时间： | 2003年3月15日 |
Regulation of tazarotene on HB-EGF in hyperproliferative epidermis of psoriasis |
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| Zheng Yan,Tan Shengshun,Peng Zhenhui,Xi Yanping.Regulation of tazarotene on HB-EGF in hyperproliferative epidermis of psoriasis[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2005,26(1):80-82. |
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| Authors: | Zheng Yan Tan Shengshun Peng Zhenhui Xi Yanping |
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| Abstract: | Objective To investigate the mechanism of tazarotene in active psoriasis vulgaris. Methods HB-EGF mRNA in active psoriatic lesions before and 10 days after the treatment with tazarotene was detected by hybridization in situ. Results There was nearly no expression of HB-EGF mRNA in psoriatic lesions (9.1%); after the treatment with tazarotene, there was expression of HB-EGF not only in basal layer (95.5%), but also focal expression in suprabasal layers of epidermis (77.3%). Conclusion Tazarotene can inhibit proliferation and induce apoptosis of keratinocytes though upregulating expression of HB-EGF in psoriatic epidermis. |
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| Keywords: | HB-EGF tazarotene psoriasis |
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