| 磷酸肌酸预处理对糖尿病大鼠心肌缺血再灌注损伤的保护作用及其机制 |
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| 引用本文： | 常建华,景桂霞,党旭云.磷酸肌酸预处理对糖尿病大鼠心肌缺血再灌注损伤的保护作用及其机制[J].西安交通大学学报(医学版),2011,32(2):151-154. |
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| 作者姓名： | 常建华 景桂霞 党旭云 |
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| 作者单位： | 西安交通大学医学院第一附属医院麻醉科,陕西西安,710061 |
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| 摘 要： | 目的探讨磷酸肌酸(PCr)预处理对糖尿病大鼠心肌缺血再灌注损伤的保护作用及其机制。方法诱导糖尿病大鼠模型,2周后随机分为3组:假手术组(D1),缺血再灌注组(D2),缺血再灌注+PCr给药组(D3);观察缺血区心肌线粒体超微结构,计算凋亡指数(AI),测定心肌匀浆中磷酸腺苷和PCr的含量,并计算能荷值(EC)。结果与D2组相比,D3组线粒体肿胀变性的损伤较轻,AI降低,ATP、PCr含量和EC均升高(P<0.05)。结论 PCr通过维护心肌线粒体结构和功能的完整性,提高心肌组织内能量物质的含量,减少心肌细胞的凋亡,从而对糖尿病大鼠心肌缺血再灌注损伤起到保护作用。
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| 关 键 词： | 磷酸肌酸 糖尿病大鼠 心肌缺血再灌注损伤 线粒体 凋亡 |
The protective effect of phosphocreatine preconditioning on myocardial ischemia-reperfusion injury in diabetic rats and its action mechanisms |
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| CHANG Jian-hua,JING Gui-xia,DANG Xu-yun.The protective effect of phosphocreatine preconditioning on myocardial ischemia-reperfusion injury in diabetic rats and its action mechanisms[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2011,32(2):151-154. |
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| Authors: | CHANG Jian-hua JING Gui-xia DANG Xu-yun |
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| Institution: | CHANG Jian-hua,JING Gui-xia,DANG Xu-yun(Department of Anesthesiology,the First Affiliated Hospital,Medical School ofXi'an Jiaotong University,Xi'an 710061,China) |
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| Abstract: | Objective To investigate the protective effect of phosphocreatine(PCr) preconditioning on myocardial ischemia-reperfusion injury in diabetic rats and its action mechanisms.Methods A diabetic rat model was induced first;two weeks later these rats were divided randomly into 3 groups: sham-operation group(D1),myocardial ischemia-reperfusion group(D2) and ischemia reperfusion + PCr preconditioning group(D3).The ultrastructure of the cardiac muscle and mitochondria was observed under an electron microscope,the c... |
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| Keywords: | phosphocreatine diabetic rat myocardium ischemia-reperfusion injury mitochondrion apoptosis |
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