血清胆红素水平与冠状动脉狭窄程度的关系

目的观察血清胆红素水平与冠心病及冠状动脉狭窄程度的关系。方法126例患者根据冠状动脉造影结果分为冠心病组(83例)和对照组(43例)。冠心病组按冠脉狭窄积分又分为三组:轻度狭窄组(15例)、中度狭窄组(35例)、重度狭窄组(33例);对照组冠脉造影正常。酶法测定甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和血清胆红素。结果冠心病组血清总胆红素为(12.30±3.84)μmol/L,直接胆红素为(4.07±1.45)μmol/L,间接胆红素为(8.23±2.82)μmol/L;正常对照组总胆红素为(14.59±4.37)μmol/L,直接胆红素为(4.66±1.55)μmol/L,间接胆红素为(9.93±3.33)μmol/L。冠心病组与正常对照组比较,总胆红素、间接胆红素及直接胆红素均降低(P<0.05)。冠脉积分与胆红素水平呈显著负相关关系(与总胆红素r=-0.263,P<0.05,与直接胆红素r=-0.187,P<0.05,与间接胆红素r=-0.261,P<0.05)。冠脉狭窄三组间胆红素水平比较无差异(P>0.05)。结论①血清胆红素水平与冠心病间存在显著负相关性,冠心病患者血清胆红素水平较正常人群明显降低;②血清胆红素水平与冠状动脉狭窄程度间无显著相关性。

Clinical observation of blood serum bilirubin level and the degree of coronary artery narrowing

Objective To observe the relationship of blood serum bilirubin level with coronary heart disease and the degree of coronary artery narrowing. Methods A total of 126 patients were divided into the coronary disease group (83) and the control group (43). According to the coronary artery narrowing integral, the 83 patients in the coronary disease group were divided into three subgroups: mild narrowing group (15 people), moderate narrowing group (35 people), and severe narrowing group (33 people). The coronary arteriography of the patients in the control group was normal. 5mL venous blood was drawn on empty stomach, and the enzyme method was used to determine glycerin, the total cholesterol, the low density lipoprotein cholesterol, the high density lipoprotein cholesterol, and the blood serum bilirubin. Results The blood serum total bilirubin in the coronary disease group was (12.30±3.84)μmol/L, direct bilirubin was (4.07±1.45)μmol/L, and indirect bilirubin was (8.23 ± 2.82 )μmol/L. The total bilirubin in the normal group was (14.59±4.37)μmol/L, direct bilirubin was (4.66 ± 1.55 )μmol/L, and indirect bilirubin was (9.93±3.33)μmol/L. The total bilirubin, indirect bilirubin and direct bilirubin were lower in coronary disease group than in normal group (P<0.05). The coronary artery integral and the bilirubin level had remarkable inverse correlation (and total bilirubin r=-0.263, P<0.05; with direct bilirubin r=-0.187, P<0.05; with indirect bilirubin r=-0.261, P<0.05). The bilirubin level in the three groups (1,2,3) with narrow coronary arteries did not differ (P>0.05). Conclusion The blood serum bilirubin level and coronary disease have remarkable negative correlation, and the blood serum bilirubin level of patients with coronary disease is lower than that of healthy people. ② The blood serum bilirubin level and the degree of coronary artery narrowing do not have remarkable correlation.