| 急性肾小球肾炎患儿IL—2产生及IL—2R表达的研究 |
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| 引用本文： | 张军,王吉安,张京田.急性肾小球肾炎患儿IL—2产生及IL—2R表达的研究[J].西安交通大学学报(医学版),1990(3). |
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| 作者姓名： | 张军 王吉安 张京田 |
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| 作者单位： | 北京电力医院儿科
(张军)，西安医科大学第一附属医院儿科
(王吉安)，西安医科大学卫生系微生物学免疫学研究室(张京田) |
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| 摘 要： | 为进一步明确急性肾小球肾炎(AGN)的发病机理,我们检测了AGN患儿外周血淋巴细胞白细胞介素-2(IL-2)活性及白细胞介素2受体(IL-2R)表达能力。结果表明AGN患儿外周血淋巴细胞IL-2活性低于对照组(P<0.05);经PHA刺激激活后的淋巴细胞IL-2R表达能力低于对照组(P<0.005);而未经PHA刺激的淋巴细胞IL-2R表达能力高于对照组(P<0.01)。提示该病的发生是由于患儿T淋巴细胞功能不足,免疫应答能力下降:T—B淋巴细胞功能失调,机体免疫调节功能紊乱的结果。
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| 关 键 词： | 急性肾小球肾炎 白细胞介素-2 白细胞介素2受体 |
THE STUDY OF THE PRODUCTION OF IL-2AND THE EXPRESSION OF IL-2R IN CHILDREN WITH AGN |
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| Zhang Jun,et al.THE STUDY OF THE PRODUCTION OF IL-2AND THE EXPRESSION OF IL-2R IN CHILDREN WITH AGN[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(3). |
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| Authors: | Zhang Jun |
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| Institution: | Department of Peking Electronal Hospital |
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| Abstract: | The activity of interleukin-2 (IL-2) and expression of interleukin-2 receptor (IL-2 R) were measured in children with acute glomerulonephritis (AGN) in order to detemine the mechanism of the disease Our results showed that the activity of IL-2 in peripheral blood lymphocytes (PBL) of children with AGN was lower than that tof the control group (P<0.05), and the unmber of expression of IL-2 in PHA-stimulated PBL was also lower than that of the control grroup (P<0.005), while the number of spontaneous expression of IL-2R in UnstimulatedPBL was higher than that of the control group (P<0.01). The data suggested that the Occurrence of the disease might result from the decreased ability of cellular immune resparse due to the function impairment of the T lymphocytes and the disorder of the immunoregulation in children with AGN due to the function disorder of T-B lymphocytes. |
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| Keywords: | acute glomerulonephritis interleukin-2 interleukin-2 receptor |
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