系统性红斑狼疮患者胰岛素抵抗情况和胰岛β细胞功能的评价

目的评价系统性红斑狼疮(SLE)患者胰岛素抵抗情况和胰岛β细胞的功能。方法以在我院住院或门诊就诊的32例女性SLE患者为研究对象,以22名健康女性为对照,测定空腹血糖水平及空腹胰岛素水平,利用HOMA公式计算HOMA-IR及HOMA-β细胞分泌功能,在SLE患者与健康对照之间进行比较。结果SLE患者与健康对照比较,空腹血糖水平无显著性差异(4.58±0.61vs.4.62±0.56,P>0.05),但在空腹胰岛素水平增加的同时(12.13±4.32vs.8.84±2.19,P<0.01),HOMA-IR(2.38±0.62vs.1.62±0.42,P<0.01)及空腹HOMA-β细胞分泌功能(232.68±32.24vs.161.78±12.17,P<0.01)明显增加。结论SLE患者体内存在胰岛素抵抗和空腹胰岛素分泌的异常。

The evaluation of insulin resistance and β-cell function in patients with systemic lupus erythematosus

Objective To evaluate insulin resistance and β-cell function in patients with systemic lupus erythematosus(SLE).Methods The study group included thirty-two female SLE patients who were hospitalized or received outpatient treatment in our hospital;the control group consisted of twenty-two healthy females.Their fasting plasm glucose and serum insulin were all tested.Homeostasis model assessment(HOMA) was used to calculate HOMA-IR and HOMA-β-cell function,and these parameters were compared between the study group and control group.Results Compared with control group,the SLE patients had significantly higher fasting insulin levels(12.13±4.32 vs.8.84±2.19,P<0.01),HOMA-IR(2.38±0.62 vs.1.62±0.42,P<0.01) and HOMA-β-cell function(232.68±32.24 vs.161.78±12.17,P<0.01),although there was no difference in the level of fasting plasm glucose(4.58±0.61 vs.4.62±0.56,P>0.05).Conclusion Patients with SLE have a higher risk of insulin resistance and abnormal insulin secretion than controls.