脑梗塞、冠心病与氧化低密度脂蛋白和血流变指标的关系

目的　探讨心脑血管病患者血浆氧化低密度脂蛋白 (ox -LDL)和血液流变学指标的变化及其相互关系。方法　用ELISA法测定 2 0例冠心病、30例脑梗塞患者和 5 0例健康对照者血浆ox -LDL ;平行测定血液流变学指标 ,并对ox LDL与血流变指标进行相关分析。结果　心脑血管病患者血浆ox LDL浓度明显高于对照组 (P <0 .0 1 ) ;血液流变学指标与正常对照组比较 ,高切全血粘度、低切全血粘度、红细胞压积比和红细胞变形指数均有较显著差异性 (P <0 .0 5或P <0 .0 1 ) ;心脑血管病患者血浆ox LDL浓度与血流变异常指标呈正相关。结论　血浆ox LDL与血液流变性异常可能与心脑血管病发病有关 ;血浆ox LDL与血液流变学检测有助于心脑血管病的诊断和治疗

Relationship between the level of oxidized low-density lipoprotein and the markers of hemorheology in cerebral infarction and coronary heart disease

Objective To explore the level of plasma oxid ized low density lipoprotein (ox LDL) and the changes of hemorheology markers, as well as the relationship of them in cerebral infarction and coronary heart disease. Methods ELISA was used to determine ox-LDL and the hemorheology markers was determined in 20 patients with coronary heart diseases, 30 patients with cerebral infarction and 50 healthy controls. The relationship between them was analysed. Results The levels of ox-LDL in the patients were much higher than those in healthy controls( P <0.01). As for hemorheology markers, the difference in blood viscosity between the patients and healthy controls was significant ( P <0.05 or P < 0.01 ). Conclusion The abnormality of the ox LDL levels and the hemorheology markers may be linked to cerebral infarction and coronary heart diseases. Determination of ox LDL levels and hemorheology markers can be helpful to diagnosis and treatment.