| 低硒对大鼠心肌肌浆网Ca转运的影响 |
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| 引用本文： | 王玉珍,贾锡安,赵君庸.低硒对大鼠心肌肌浆网Ca转运的影响[J].西安交通大学学报(医学版),1998(2). |
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| 作者姓名： | 王玉珍 贾锡安 赵君庸 |
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| 作者单位： | 西安生物化学教研室!西安，710061，西安生物化学教研室!西安，710061，西安生物化学教研室!西安，710061 |
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| 基金项目： | 国家“七五”攻关资助!75－62－03－03 |
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| 摘 要： | 用克山病病区低硒粮饲料和该饲料补硒喂养大鼠，动态观察了喂养1、2和3个月时两组大鼠心肌肌浆网钙转运功能的改变。结果表明：在各喂养期，低硒组大鼠心肌肌浆网Ca2+－ATPase活性和Ca2+摄取速率均明显低于补硒组，而脂质过氧化物浓度则显著高于同期补硒组。提示低硒大鼠心肌肌浆网Ca2+－ATPase活性和Ca2+摄取下降可能是脂质过氧化增高的结果。
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| 关 键 词： | 硒 Ca~(2+)－ATPase Ca~(2+)摄取 心肌肌浆网 大鼠 |
EFFECT OF SELENIUM DEFICIENCY ON Ca TRANSPORT OF MYOCARDIAL SARCOPLASMIC RETICULUM FROM RAT |
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| Wang Yuzhen,Jia Xi'an, Zhao Junrong.EFFECT OF SELENIUM DEFICIENCY ON Ca TRANSPORT OF MYOCARDIAL SARCOPLASMIC RETICULUM FROM RAT[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1998(2). |
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| Authors: | Wang Yuzhen Jia Xi'an Zhao Junrong |
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| Institution: | Department of Biochemistry |
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| Abstract: | Two groups of weanling SpragueDawley rats were fed on a low-selenium basal diet and the same diet supplemented with sodium selenite,respectively,for 1, 2 and 3 months. At each feeding time,the Ca2 -ATPase activity,Ca2 uptake rateand the capacity of Ca2 uptake in isolated cardiacsarcoplasmic reticulum from the Se-deficient ratswere decreased significantly compared to those fromthe Se-supplemented rats; but the content of lipidperoxide in sarcoplasmic reticulum from the Se-deficient rats was significantly higher than that from Sesupplemented rats. The results suggest that the enhancement of lipid peroxidation via Se deficiencymight be responsible for the decreases of Ca2 -AT-Pase and Ca2 uptake activities in sarcoplasmic reticulum in Se-deficient animals. |
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| Keywords: | selenium Ca~(2 )-ATPase Ca~(2 ) uptake cardiac sarcoplasmic reticulum rat |
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