| 大骨节病患区和邻近非患区不同硒水平儿童尿中羟赖氨酸含量的初步探讨 |
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| 引用本文： | 蒋一方,白偲,于志道,曹敏,蒋忠,张增强.大骨节病患区和邻近非患区不同硒水平儿童尿中羟赖氨酸含量的初步探讨[J].西安交通大学学报(医学版),1987(2). |
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| 作者姓名： | 蒋一方 白偲 于志道 曹敏 蒋忠 张增强 |
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| 作者单位： | 西安医科大学地方性骨病研究室，西安医科大学地方性骨病研究室，西安医科大学地方性骨病研究室，西安医科大学生物化学教研室，西安医科大学生物化学教研室，西安医科大学生物化学教研室 |
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| 摘 要： | 1.大骨节病患区和邻近非患区不同硒水平儿童尿羟赖氨酸排出情况不同,凡是尿硒排出量低的儿童,其尿羟赖氨酸排出量也低,二者存在高度正相关关系。2.低硒儿童尿羟赖氨酸排出减少被认为可能与前α-肽链上赖氨酸羟化不全有关。3.本文着重对大骨节病儿童分组指标的选择做了详细讨论,指出合理分组是获得生化代谢变化正确信息的基础。
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A STUDY ON URINARY HYDROXYLYSINE CONTENTS IN THE CHILDREN WITH DIFFERENT SELENIUM LEVELS FROM KASCHIN-BECK DISEASE AFFECTED AND NON-AFFECTED AREAS |
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| Jiang Yifang.A STUDY ON URINARY HYDROXYLYSINE CONTENTS IN THE CHILDREN WITH DIFFERENT SELENIUM LEVELS FROM KASCHIN-BECK DISEASE AFFECTED AND NON-AFFECTED AREAS[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1987(2). |
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| Authors: | Jiang Yifang |
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| Abstract: | The urinary Se and hydroxylysine contents were determined in 162 cases from Kasehin-Beek disease affected and non- affected areas.The results showed that the urinary hydroxylysine outputs were lower in children with lower Se levels than with highter Se ones.There was a close relationship between urinary Se and hydro- xylysine outputs (r=0.97,n′=3,p<0.01). Both hydroxylysine and hydroxyproline contents in urine were greatly decrea- sed in children with Se deficiency.This suggested that the hydroxylations of lys- ine and Proline might be inhibited by Se deficiency in the children with low Se status. |
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| Keywords: | selenium hydroxylysine endemic disease |
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