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1.
In1985,DerkneckmadethecloneofTGFβ1fromthegenebankofhuman'splacentaandcDNAoffibromasarcomacellline.PreviousstudieshaveshowedthatTGFβ1existsinmultiplenormalsomaticcells,hematopoieticcellsandembryoniccellsofhumanbeingorothermammals.Cellsandtumortissuewh…  相似文献   

2.
Thethyroidcanceristhemostcommoncarci nomaintheendocrinicneoplasms.Thyroidcarcino ma,dependingonthepathologicaltype,hastwo thoroughlypolarizedcharacteristicsofprogression. Undifferentiatedcarcinomaischaracterizedbyex ceptionallyquickprogressionwithdirep…  相似文献   

3.
Recently,alargenumberofresearchesindicatedthatoccurenceanddevelopmentofbreastcarcinomaswerecorrelatedwithhighexpressionofblockingapoptosisoncogene,mutationofantioncogeneandexpressionofcontrollingcellproliferativeoncogene.Therewerefewreportsondocumentsofquantitativestudyofexpressionaboutblockingapoptosisoncogene--hcf--2(Bcellleukaemia/lymphomagene),productofP53proteinandproliferatingcellnuclearantigen(PCNA)inbreastcarcinoma.Ourpurposewastoinvestigatequantitativeindexinrelationtoclinicalpathol…  相似文献   

4.
Inthewholeworld,morethan350million peoplearechronicinfectionwithhepatitisBvi rus[1].ThepatientswithHBVchronicinfectionare atincreasedriskofdevelopingcirrhosisandhepato cellularcarcinoma(HCC).Continuousandsus tainedsuppressionofHBVreplicationcanprevent thedevelopmentofcirrhosisandHCC[2].Lamivudinewasthefirstpotentiallynon cyto toxicandoralnucleotideanalogueapprovedfortrea tingCHB.Treatmentwithlamivudineusuallyre ducesserumHBV DNArapidly,enhancestransami nasenormalization,andimprovesliv…  相似文献   

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