PRELIMINARY STUDY OF OMENTUM TRANSPOSITION TO BRAIN FOR TREATMENT OF ALZHEIMER'S DISEASE

Objective To learn the effect of omemtum transposition to the brain of patients with Alzheimer's disease. Methods Ten consecutive patients, aged 58 - 81 years old, underwent graft of their elongated pedicled omentum onto their left frontal-temperal-parietal cerebral cortex. Those patients, who had more than five years of dementia with low mini mental-state examination (MMSE) scores of 2 -15, were diagnosed by a neurologist. All subjects underwent single photon evoked computer tomography (SPECT) pre- and post-operatively.SPECT results were analyzed semi-quantitatively by calculation of the left/right radioactivity counts symmetry index (Si). The patients were followed up to one year. The outcome was evaluated by the neurologist with a modified scale of activities of daily living (mADL) as well as the MMSE. Results Three months following the surgery,the Si of SPECT increased from ( 98. 7 ± 1.9) % to ( 103. 9 ± 2.3 ) % ( P = 0. 0307). The neurological and neuropsychological testing scores increased insignificantly during the follow-up period. By the one year, the MMSE score rose from 8. 7 ± 1.4 to 10. 7 ± 1.8 ( P ＞ 0. 05 ), while the mADL from 13.3 ± 1.8 to 16. 9 ± 2. 0 ( P ＞ 0. 05 ). One of the patients suffered a heart attack, two had epileptic episodes postoperatively. Conclusion We believe that omental transposition to the brain augments cerebral blood flow, which might be helpful to decelerate the processing of Alzheimer's disease. However, it is still a potentially risky procedure for the elderly.     

INTELLIGENT TOOLS FOR PREDICTING ANXIETY OF ALZHEIMER'S PATIENTS

Objective To predict the incidence of anxiety in Alzheimer's disease (AD) patients by using machine-learning models. Methods A large randomized controlled clinical trial was analyzed in this study, which involved AD patients and caregivers from 6 different sites in the United States. The incidence of anxiety in AD patients was predicted by backpropagation artificial neural networks and several machine learning models, including Bayesian Networks, logistic regression, ADTree, J48, and Decision table. Results Among all models for predicting the incidence of anxiety in AD patients, the artificial neural network with respectively 6 and 3 neurons in the first and second hidden layers achieved the highest predictive accuracy of 85.56 %. The decision tree revealed three main risk factors: "caregiver experiencing psychological distress", "caregiver suffering from chronic disease or cancer", and "lack of professional care service". Conclusion The unique ability of artificial neural networks on classifying nonlinearly separable problems may substantially benefit the prediction, prevention and early intervention of anxiety in Alzheimer's patients. Decision tree has the double efficacy of predicting the incidence and discovering the risk factors of anxiety in Alzheimer's patients. More resources should be provided to caregivers to improve their mental and physical health, and more professional care services should be adopted by Alzheimer's families.     

大白鼠同神经与不同神经输入对脊髓背角神经元的会聚

实验用大白鼠。分级刺激腓肠神经和腓肠肌神经,对被激活的背角神经元进行观察,进而对皮肤、肌肉神经传入会聚神经元进行了分类,发现同一神经刺激被激活的背角神经元可分为A、A—C和C 3个类型,其中A—C型占多数(皮神经激活68%,肌神经激活50.4%)。实验中记录到125个皮,肌会聚神经元(CMCN),按对皮、肌A类和C类传入纤维的反应,分为A—A、A—AC、AC—A,AC—AC、C—C 5型,其中AC—AC和A—A型占多数(分别为46.27%和26.12%).结果提示,上述多种会聚形式,可能是皮、肌粗、细初级传入在脊髓水平对感觉传入(特别是痛觉)进行调制的基础,因此将在镇痛、痛过敏中起作用。     

脑电图检查对散发性脑炎随访的评价—附32例76份临床及脑电图分析

本文通过对32例随访散发性脑炎病人76份脑电图的分析,提出散发性脑炎病人的脑电图变化与临床转归密切相关,约83.87%表现为相平行的关系,且临床好转先于脑电图好转。认为在当前散发性脑炎尚无确切的诊断标准、无特异性病原学检查方法的情况下,随访中多次描记脑电图对散发性脑炎转归、预后的判断及回顾性诊断不失为简便而有意义的方法。     

多发性骨髓瘤48例误诊分析

48例多发性骨髓瘤入院时误诊为骨骼。肾脏、肝脏.造血和神经系统等疾病,而本身被漏诊,漏、误诊率66.7%。临床分析表明,40岁以上病人如有:进行性骨痛;原因不明的贫血或红细胞缗钱现象;血沉明显增快或高球蛋白血症;反复感染,持续性蛋白尿或不伴高血压的肾衰;扁平骨肿块;脊髓压迫或神经根受损等情况时,应疑及本病,需进一步检查明确诊断。     

乳腺肉瘤21例临床分析

我院自1956年到1990年共收治乳腺恶性肿瘤病人2644例,其中经病理确诊的乳腺肉瘤21例,占同期乳腺恶性肿瘤病人的0.8%。6例腋下淋巴结肿大,占28.6%。病检均非肿瘤转移。本组资料表明乳腺肉瘤的发病年龄较乳癌为轻,45岁以上及病史1年以上者预后较好。因乳腺肉瘤多经血道转移或局部浸润,很少转移到腋下,治疗以肿瘤切除和乳腺单切为主,放疗的价值还需进一步探讨。     

大龄儿童先天性髋脱位的手术治疗

１９８９～１９９４年采用一次性髋臼成形术及股骨旋转短缩截骨术治疗先天性髋脱位１４例（１５髋）。手术时年龄７～１３岁。术后平均随访３年５个月。结果：优９例，良５例，可１例。优良率为９３．３％。作者认为，这种联合手术对治疗大龄儿童先天性髋脱位是一种安全有效的方法。     

黄芪水提物对多抗甲素抗肿瘤作用的影响

本文观察了黄芪水提物对多抗甲素口服液抗肿瘤作用的影响,发现黄芪能增强多抗甲素的抗肿瘤作用,表现为黄芪多抗甲素胃饲组小鼠脾T细胞对ConA的反应性增强,瘤细胞活力下降。S_(180)荷瘤鼠生存期延长,死亡百分率下降。基于多抗甲素的肽聚糖本质,多抗甲素能激活单核—巨噬细胞和黄芪可诱生Υ-干扰素,本文提出:Υ-干扰素对α-肿瘤坏死因子合成和杀伤作用的正向调节可能是黄芪水提物增强多抗甲素抗肿瘤作用的重要机理。     

淫羊藿总黄酮对家兔血液流变学指标的影响

研究淫羊藿总黄酮(FEBM)对家兔血液流变学指标的影响,结果表明:FEBM在0.1g/kg或0.4g/kg时,每天两次灌胃,连续3d,可抑制家兔体外血栓形成;在0.4g/kg时可降低2～40s~(-1)切变率时的全血粘度和抑制红细胞的聚集。实验说明FEBM抑制血栓形成的主要因素可能和降低红细胞聚集性及降低全血粘度有关。     

膜离子通道闸门调制剂对神经兴奋性的影响

在38例螯虾腹大神经和60例蟾蜍坐骨神经-腓神经标本上,观察了乌头碱(AC)、钙离子(Ca~(2+))和脱氧胆汁酸(DOC)3种膜离子通道闸门调制剂对神经兴奋性以及兴奋性指标—标准电量(a)的影响。结果表明,a与钠通道的激活速率有关,它可能反映了打开钠通道活化闸门、产生动作电位所需要的电量变化。     

OBSERVATION OF THE EFFECTS OF ZHENXUANYIN ON CBF OF RATS WITH VERTEBROARTERIAL ISCHEMIA AND CBF OF HEALTHY RATS

ＺＸＹｉｓａｎｅｘｐｅｒｉｅｎｔｉａｌｒｅｃｉｐｅｕｓｅｄｂｙｔｈｅａｕｔｈｏｒｔｏｔｒｅａｔｖｅｒｔｅｂｒｏｂａｓｉｌａｒｉｓｃｈｅｍｉｃｄｉｚｚｉｎｅｓｓ（ＶＩＤ）ｃｌｉｎｉｃａｌｌｙｉｎＣｈｉｎａ．ＩｔｉｓｃｏｍｐｏｓｅｄｏｆｐｕｒｅＣｈｉｎｅｓｅｍｅｄｉｃｉｎａｌｈｅｒｂｓ，ｓｕｃｈａｓｇａｓｔｒｏｄｉａｔｕｂｅｒ，ｐｏｒｉａｃｏｃｏｓ，ｌｉｇｕｓｔｉｃｕｍｗａｌｌｉｃｈｉｉ，ｅｔｃ．ＶＩＤｉｓｃａｕｓｅｄｂｙｔｒａｎｓｉｅｎｔｃｅｒｅｂｒａｌｉｓｃｈｅｍｉａ．Ｉｔｉｓａｓｉｇｎａｌｓｙ…     

DISTRACTION OF OSTEOGENESIS AND LENGTHENING OF CRANIOFACIAL BONE-PRELIMINARY REPORT OF AN EXPERIMENTAL RESEARCH

Themethodforgradualcallusdistractionofosteogenesis(Do)inenchondralbonehasbeenu-niversallyappliedontheorthopedicclinics.DowasfirstlyusedonfemurlengtheningbyanItal-ian,Codivilla(19O5),onthepatientsofunequiva-lentofstature,whilethetibiawaslengthenedbyAbbotin1927[1i.Becauseoftheseverecomplica-tionsasedema,necrosisofskin,infections,angu-lardeformity,andthedelayedmineralizationofthedistractedbone,themethoddidn'tarousedthein-terestofpeopleuntilearly2Othcentury,195Ost2i.ItwasIlizarov(aRussiansurge…     

IMPLEMENTATION OF GRADIENT-BASED ESTIMATION OF HMM PARAMETERS

IntroductionIn Hidden Markov Model ( HMM) - basedspeech recognition systems,it is very importanttoset the parameters of HMMs correctly.Conven-tional training algorithms such as Baum- Welch al-gorithm,are based on the criterion of maximumlikelihood( ML) .The strength of Baum- Welch al-gorithm lies in its fast convergence andmonotonous improvement[1] . For other criteriasuch as maximum mutual information,however,such an algorithm does not exist.In this case,acommon resort is a gradient- b…     

视屏显示终端的职业危害

本文进行了视屏显示终端职业危害因素的监测及对操作人员身体影响的评价,表明其具有诸多的职业危害因素,主要为不良的微气候和空气离子状态,较低的照度、较强的噪声,尚有一定量的X线幅射及不良的人机关系。上述复杂的危害因素形成多方面的健康效应,主要表现在神经系统、精神行为、眼、骨骼肌、女性月经和生育方面,但以视屏显示终端作业工作量大的18岁～25岁年龄组较为明显。提示需加强对视屏显示终端作业人员综合性的职业卫生防护措施。     

山豆根碱对实验性血栓形成的影响

本文观察了山豆根碱对实验性血栓形成的影响。结果表明,静脉注射20mg/kg山豆根碱,明显抑制大鼠血小板血栓和电刺激诱发的动脉血栓形成,对静脉血栓形成无影响;体外明显抑制大鼠血小板粘附于胶原,存在剂量依赖关系。这些说明,山豆根碱具有抗动脉血栓形成作用,作用机理可能与抑制血小板粘附和聚集有关。     

胎儿食管粘膜上皮细胞DNA含量的细胞光度术及细胞增殖分析

本文采用Feulgen-DNA含量细胞分光光度术动态地测量了林县不同胎龄人的食管上皮细胞DNA含量及其染色体倍性的精确变化,DNA含量及相关细胞频数关系用直方图显示吸收光度量。结论是:胎龄愈高,DNA含量愈集中分布,最大峰值的G_1的造型愈高,DNA值的标准差(s)和标准误(s_?)愈小。DNA含量在2～4C范围,符合一个增殖细胞群体的特征。食管上皮的增殖和分化情况由细胞分光光度计所测量的DNA含量的分级依据和细胞形态学特征所反映,同时探讨了在增殖与分化“失常”的微细形态学改变之前可能显示出精微的DNA含量的改变。     

北方六省（区）MMPI中文版的结构效度研究

通过对ＭＭＰＩ基本量表间的相关分析和因子分析，并与跨文化资料进行比较，发现中文版和原版所测的人格维度基本一致：主要负荷精神质（Ｐ），神经质（Ｎ）和社会内向（Ⅰ）因子，所解释的变异量为７０％左右；其次，负荷性度（Ｍ）和社会判断和适应因子（Ａ）。５个因子可解释变异量的８０％左右。判别分析结果发现，ＭＭＰＩ对正常组和８组精神疾病的正确划组率达７９．０２％至８８．２８％。提示中文版有较好的结构效度。     

EFFECTS OF TOTAL SAPONINS OF PANAX NOTOGINSENG AND LIGUSTRAZINE ON THE PROLIFERATION OF CEREBRAL MICROVASCULAR ENDOTHELIAL CELLS OF RATS

Ｅｎｄｏｔｈｅｌｉａｌｃｅｌｌｓ (ＥＣｓ)ｆｕｎｃｔｉｏｎａｓｔｈｅｂａｒｒｉｅｒｏｆｔｈｅｂｒａｉｎａｎｄｒｅｌａｔｅｔｏｔｈｅｓｅｃｒｅｔｉｏｎｏｆｓｏｍｅｅｎｄｏ ｃｒｉｎｅｓ.Ｔｈｅｉｒｄｙｓｆｕｎｃｔｉｏｎｉｓｃｌｏｓｅｌｙｒｅｌａｔｅｄｔｏｔｈｅｏｃｃｕｒｒｅｎｃｅａｎｄｄｅｖｅｌｏｐｍｅｎｔｏｆｃｅｒｅｂｒａｌｖａｓｃｕｌａｒｄｉｓｅａｓｅｓ[1] .ＤａｍａｇｅｔｏＥＣｓｉｓｔｈｅｆｉｒｓｔｓｉｇｎａｎｄａｂａ ｓｉｃｆａｃｔｏｒｏｆｃｅｒｅｂｒａｌｉｓｃｈｅｍｉａ .Ｔｈｅｒｅｆｏｒｅ ,…     

INFLUENCE OF ETHANOL ON TOXICOKINETICS OF ACONITINE

ＩＮＦＬＵＥＮＣＥＯＦＥＴＨＡＮＯＬＯＮＴＯＸＩＣＯＫＩＮＥＴＩＣＳＯＦＡＣＯＮＩＴＩＮＥＸｕＷｅｉ；ＨｕＢｉｎｇｗｅｉ；ＣｈｅＸｉａｎｇｍｉｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＴｏｘｉｃｏｌｏｇｙ，ＦａｃｕｌｔｙｏｆＦｏｒｅｎｓｉｃＭｅｄｉｃｉｎｅ，Ｘｉ...     

先天性肾积水患者的超微结构病理及临床分析

对38例单纯先天性肾积水肾盂输尿管连接部（UPJ）组织作透射电镜观察，结果：其主要超微结构病理改变是平滑肌细胞间有大量胶原料堆组织堆积，平滑肌细胞相互分离，肌细胞本身发育不良，胞膜皱折、锯齿状、指状突起，线粒体肿胀破坏。提示积水的原因是UPJ部位功能性梗阻。