人心室中隔动脉

将111例人心分为成人、儿童、婴儿三组。用三种研究方法即:X射线血管照相法、显微解剖法和腐蚀铸型法。得出以下结果:室中隔血供共有五个来源:1.前室中隔动脉——为供应室中隔的主要动脉,分布于室中隔前2/3区域。2.后室中隔动脉——供应室中隔后1/3区域。3.房室结动脉——分布于室中隔后上1/5区域,为房室结区的一条重要动脉。4.后上室中隔动脉——出现率为70%,分布于室中隔后上1/3～1/4区域。5.降中隔动脉——出现率为64.8%,分布于室中隔上、中部、是前、后室中隔动脉潜在侧支循环通道。本文对室中隔内动脉行走规律及分布范围,以及室间孔出现时,其动脉分布特点等进行了讨探。     

国人心脏室中隔形态观察

<正> 对人心室中隔形态,特别对其上缘的构成除E.Henry_-~1有过描述外,国内还未见详述。为了适应心脏内、外科发展的需要,我们对60例人心室中隔标本(儿童30例,成人30例)左、右侧面结构、边缘等进行了观察与测量。     

神经内镜治疗颅内病变的临床应用

目的探讨神经内镜的临床适应证、操作要点及其优缺点。方法采用神经内镜治疗颅内各种病变69例,其中垂体腺瘤6例,蛛网膜囊肿21例,脑积水18例,透明隔囊肿6例,颅内表皮样囊肿8例,血管网织细胞瘤9例,颅内多发性转移瘤1例。结果69例患者术后临床症状和体征均有不同程度的恢复或好转,头颅CT、MRI复查颅内病灶明显改善。结论神经内镜对于颅内多种病变的治疗具有手术创伤小、术后反应轻和患者恢复快的特点,是目前微创神经外科治疗的首选方法。     

蝶窦显微外科解剖

用成人尸头30个(60侧)及成人干颅骨51个(102侧),结合临床经鼻腔,蝶窦而达垂体的显微外科手术入路,对蝶窦及其周围血管神经关系进行了观察,统计和探讨,提供了国人的应用解剖资料。     

同时性结直肠癌肝转移同期与分期手术疗效的Meta分析

目的对比分析同时性结直肠癌肝转移行同期手术与分期手术切除转移灶的疗效。方法通过计算机文献检索ISI Web of Knowledge、Pubmed及中国期刊网,检索国内外自1990年1月至2010年12月间公开发表的有关结直肠癌肝转移治疗的文章。通过Meta分析对比同时性结直肠癌肝转移同期、分期术后围手术期并发症、死亡率、5年生存率。结果同时性结直肠癌肝转移同期手术切除组与分期手术切除组比较,同期手术组围手术期并发症发生率36.4%与分期手术组35.6%(P=0.957)相似,在围手术期死亡率(OR=1.91,95%CI:0.90～4.08,P=0.09)及5年生存率(OR=1.08,CI:0.73～1.61,P=0.69)方面无统计学差异。结论与分期切除相比,同时性结直肠癌肝转移行同期切除同样安全、有效。     

人心房室隔内新的兴奋传导通路

根据对35例国人正常心脏标本、2例房室隔水平连续切片和2例房室交点区矢状连续切片的观察，发现从右房经界嵴至房室隔内的居室结有三条传导兴奋的通路：①从冠状窦下壁至房室结后缘；②从冠状窦口周围沿右房心内膜下至房室结浅层；③经冠状窦口下方，沿三尖瓣隔侧瓣上方右房心内膜下至房室结下缘。     

房室隔疏松组织间隙及其有关的组织结构

利用４例人心房室隔水平连续组织切片，观察了房室隔内的疏松组织间隙和与其有关的组织结构：包括心房肌至房室结的过渡性心肌纤维，冠状窦末段的形态结构以及冠状窦口后方的右房后窝等。并结合临床进行了讨论。     

17例脊髓纵裂的CT结果分析

我院骨科自1978～1993年共收治先天性脊柱畸形427例,手术证实合并脊髓纵裂40例,其中17例术前经CT检查确诊。18个骨嵴中（1例为2个骨嵴）,16个为骨性嵴,2个分别为软骨性和纤维性嵴。CT特征:椎管中央的纵行骨嵴将脊髓或马尾分为两部分,多数骨嵴两侧蛛网膜下间隙及脊髓不均称;该部椎管扩大;椎体及附件结构紊乱。CT是一理想、可靠的诊断方法,不仅能准确诊断损害的平面,而且能显示椎管的自然状态和骨嵴的轮廓及种类。     

冠状动脉内支架置入术45例临床分析

目的　分析 45例冠脉内支架置入术 ,探讨其临床应用价值。方法　男性 41例 ,女性 4例 ,平均年龄 55.8岁。共 48支靶血管内置入支架 49只 ,单纯型病变 5例 (1 0 .2 % ) ,复杂型病变 44例 (89.8% ) ,包括闭塞性病变 3例。 de novo置入 1 4例 ,suboptimal置入 1 4例 ,bail- out置入 1 7例。多支架置入 3例。结果　手术成功率 1 0 0 % ,均无严重急性血管并发症和出血并发症。冠脉造影 (CAG)随访 5例 ,平均随访 1 0 4 d,其中 1例出现再狭窄 (2 0 % ) ,再次行经皮穿刺冠脉腔内成形术 (PTCA)有效。结论　冠脉内支架植入术是一种安全有效的介入治疗技术 ,急性心梗者手术的成功标志着适应证范围进一步扩大     

大白鼠冠状动脉的解剖观察

本文用透明和解剖剥离等方法观察了130例大白鼠心脏的冠状动脉。鼠心左冠状动脉主干和前降支始段与伴行静脉的关系极为密切。复制心肌梗塞模型时,结扎左冠状动脉可在动脉园锥与左心耳之间进行。左室支粗大,是前降支(或旋支)的直接延续,分支分布到左室前、后壁的大部分。鼠心有独立的空间隔动脉(56.2%起于右冠状动脉,43.8%起于左冠状动脉)供应室间隔的大部分。24.6%的鼠心有上间隔动脉(起于右冠状动脉)供应室间隔之上部。后降支的出现率为17.7%。冠状动脉的分布类型以均衡型居多(72.3%),右优势型次之(24.6),左优势型最少(3.1%)。以上结果与狗、兔、猫等动物及人的资料作了比较讨论。     

Effects of labor analgesia on maternal and neonatal outcome by epidural low concentration of bupivacaine combined with anisodamine

Objective To observe the effects of labor analgesia on maternal and neonatal outcome by epidural application of 0.125% bupivacaine combined with anisodamine on the labor stage, and modes of delivery and neonatal Apgar's score. Methods A total of 220 primiparaes with full-term pregnancy, monocyesis and fetal head presentation without any obstetrical or systematic complications were chosen and divided into analgesic group and control group (110 in each group). The mixture of bupivaeaine and anisodamine was injected into the epidural space of the parturients in the analgesic group while those patients in the control group did not receive any analgesics. Results The analgesic effect was satisfactory (91.8 %), and no side effects occurred in the second stage of labor. The instrument delivery rate was lower in the analgesic group, and there was no significant difference between the two groups in neonatal Apgar's score. Conclusion The method is feasible in clinic for labor pain relief without increasing the rate of dystocla and complications of delivery.     

容量超负荷型及容量合并压力超负荷型心脏心肌胶原的变化

为研究容量超负荷型心脏病心肌胶原含量的改变，我们应用羟脯氨酸法，观察了19例先天性心脏病房／室间隔缺损患者右心耳心肌胶原含量的变化，并与5例健康意外死亡者作对照，结果表明：容量超负荷型心脏患者，无论是房间隔缺损还是空间隔缺损，心肌胶原含量与正常人相比显著降低，但当房／室间隔缺损合并肺动脉高压后，心肌胶原含量则增多，与正常人相比有显著性差异。     

NOVEL PHOSPHORYLATION SITES OF EUKARYOTIC INITIATION FACTOR－4E AND EVIDENCE THAT PHOSPHORYLATION STABILIZES INTERACTIONS OF T

ＮＯＶＥＬＰＨＯＳＰＨＯＲＹＬＡＴＩＯＮＳＩＴＥＳＯＦＥＵＫＡＲＹＯＴＩＣＩＮＩＴＩＡＴＩＯＮＦＡＣＴＯＲ－４ＥＡＮＤＥＶＩＤＥＮＣＥＴＨＡＴＰＨＯＳＰＨＯＲＹＬＡＴＩＯＮＳＴＡＢＩＬＩＺＥＳＩＮＴＥＲＡＣＴＩＯＮＳＯＦＴＨＥＰ～２５ＡＮＤＰ～２２０...     

Diagnosis and excision of breast multi-focal lesions by ultrasound-guided vacuum-assisted biopsy: a comparative evaluation

Objective To compare and evaluate the efficacy of diagnosis and excision for appropriately selected breast multi-focal lesions and solitary lesion by ultrasound-guided vacuum-assisted biopsy (UGVAB). Methods Among 392 appropriately selected patients, 187 patients with multi-focal lesions and 205 patients with solitary lesion were treated by the 8-gauge UGVAB from May 2007 to June 2009. All lesions were removed as completely as possible. The patients with benign pathology underwent physical and ultrasound examinations at one week and 6 months after procedure. Results During the procedure, only three patients had vasovagal syncope and twenty others complained of other intraoperative discomfort. An accurate pathological diagnosis was obtained in all lesions. There was no apparent false-negative result among the 696 lesions with benign pathology at a follow-up of 6 months after procedure. The rates of malignant or premalignant pathology, postoperative complications and residual lesions in patients with multi-focal lesions were higher than those in patients with solitary lesion. If each lesion was considered as a subject of study, there was no significant difference between the two groups. Conclusion UGVAB is an effective method for diagnosis and excision of appropriately selected breast multi-focal lesions and can be used routinely.     

室间隔缺损并肺动脉高压102例外科治疗

先天性心脏病室间隔缺损（ＶＳＤ）是一常见多发病，由于存在左向右分流，常导致肺动脉高压（ＰＨ），使围手术期死亡率增加，预后不佳，故早期发现、早期手术治疗己被重视。本文对１０２例ＶＳＤ·ＰＨ患者外科手术治疗进行分析，并对手术适应症、手术径路、并发症预防及术后处理进行讨论。     

秦沈客运专线路涵过渡段动应力测试与分析

对秦沈客运专线DK49 689．0-DK49 700．7路涵过渡段进行了动应力测试，分析了动土压力与列车速度的关系、沿线路纵向分布以及随深度的变化．结果表明：动土压力随列车速度提高而增大，当列车速度超过220km／h时，动土压力基本趋于稳定，但始终大于准静态土压力；随深度增大，动土压力迅速衰减，趋于准静态土压力．此外，动土压力还受路基结构的影响，涵洞顶路基的动土压力明显大于一般路基的动土压力．     

经胸超声心动图诊断房间隔完整的部分性肺静脉异位引流

目的　探讨房间隔完整的部分性肺静脉异位引流的超声心动图特征。方法　经胸二维超声心动图及彩色多普勒血流图检测 3例房间隔完整的部分性肺静脉异位引流患者。结果　经胸超声心动图诊断准确率为 10 0 %。 3例患者房间隔均完整 ,无心内分流及其他畸形。 3例患者心内冠状静脉窦型 2例 ,心内右房型 1例 ;异常连接 2例为双支左肺或右肺静脉 ,1例为单支右上肺静脉。 3例均表现为不同程度的右心系统扩大。结论　经胸超声心动图对无其他原因所致的右心负荷过重者 ,应高度怀疑部分性肺静脉异位引流存在的可能 ,常规检查肺静脉位置及开口 ,必要时辅以经食道超声心动图 ,有助于早期诊断     

Increased expression of the 20S proteasome in peripheral blood mononuclear cells of type 2 diabetic patients

Objective To investigate the dynamic expression of the 20S proteasome in peripheral blood mononuclear cells (PBMCs) of type 2 diabetic patients without vascular complications. Methods PBMCs were prepared from 30 type 2 diabetic patients and 30 nondiabetic controls. The general indexes including weight, height and blood pressure were recorded. Fasting plasma glucose, fasting plasma insulin and glycosylated hemoglobin were measured. The protein level of the 20S proteasome was measured by Western blotting. The mRNA expression levels of the 20S proteasome β1, β2 and β5 subunits were detected by real-time PCR. Results Compared with that in the nondiabetic controls, the protein level of the 20S proteasome was significantly increased in the diabetic patients and was positively associated with glycosylated hemoglobin. Conclusion Type 2 diabetic patients without vascular complications have an increased 20S proteasome expression, the significance of which needs to be explored by further study.     

胆总管结石取石术的Meta分析

目的比较胆总管结石的开腹手术治疗与内镜治疗的临床疗效。方法通过电子检索和手工检索全面收集关于胆总管结石的开腹手术治疗和内镜治疗的随机对照实验,并按Cochrane协作网推荐的方法进行Meta分析。采用固定效应模型,对符合纳入标准的6个实验共407例患者进行Meta分析。结果与ERCP内镜取石组相比较,开腹手术组在一次手术后结石残留率[OR0.39,95%CI(0.25,0.75),P=0.003]、患者再次手术率[OR0.33,95%CI(0.19,0.60),P=0.0002]方面差异均有统计学意义,在围手术期并发症率方面[PetoOR1.10,95%CI(0.69,1.76),P=0.67]无统计学差异。结论目前研究资料显示,开腹手术取石较内镜取石在结石清除效果方面有一定优势,而围手术期并发症率方面无统计学差异。     

脊髓纵裂神经缺陷机制探讨

对２９例脊髓纵裂的神经功能状态进行临床评价及胫后神经皮层体感诱发电位（ｐｏｓｔｅｒｉｏｒｔｉｂｉａｌｎｅｒｖｅｃｏｒｔｉｃａｌｓｏｍａｔｏｓｅｎｓｏｒｙｅｖｏｋｅｄｐｏｔｅｎｔｉａｌ，ＰＴＮＣＳＥＰ）检查。结果：患病组２９例两下肢间神经缺陷的临床评分及ＰＴＮＣＳＥＰ有显著差异（Ｐ＜０．０５），患病组５８根ＰＴＮＣＳＥＰ明显异常；手术组２０例术后神经缺陷的临床评分及ＰＴＮＣＳＥＰ异常明显改善（Ｐ＜０．０５），非手术组９例随访后则无改善（Ｐ＞０．０５）。结果提示神经缺陷的机理是脊髓纵裂间隔对脊髓的牵拉和纵裂脊髓单侧发育异常。