共查询到9条相似文献，搜索用时 46 毫秒
1.
为探讨匹罗卡品家兔点眼对葡萄膜巩膜途径房水流出色的影响，用1％匹罗卡品（Pilocarpine，PC）对家免单侧点眼。并用0.1mmol／L异硫氰酸荧光素牛血清白蛋白（Fluoreceinisothlocyanate－bovineserumalbumin，FITC－BSA）持续前房灌注30min。测定前、后葡萄膜等6种组织的FITC－BSA含量，计算每眼的葡萄膜巩膜层水流出量（Uveosderdoutflow，Fu）。分别比较点眼前后眼压和点眼后双眼的Fu。结果示：PC点眼后1h处理眼眼压为（0．70±0．08）kPa，下降率为25％（P＜0．01），对照眼眼压无显著变化（P＞0．05）；点眼后2h处理眼Fu值为（0．123±0．026）μl／min，对照眼Fu值为0．177±0．032）μl／min，双眼比较差异有显著性（P＜0．05）。说明1％PC单侧点眼可降低正常家兔眼压，PC可阻断家兔葡萄膜巩膜途径房水外流，兔眼的眼压下降主要为前路排出增加所致。 相似文献
2.
目的 探究西洛他唑对糖尿病小鼠肠黏膜屏障的影响。方法 从GEO数据库中下载GSE142153数据集,分析其差异基因变化。将8周龄的雄性db/db小鼠以及对照m/m小鼠随机分为m/m+溶剂组、m/m+西洛他唑组、db/db+溶剂组、db/db+西洛他唑组。各组小鼠分别用西洛他唑和相应溶剂灌胃4周。干预结束后,检测血清sCD40L水平及肠道CD40表达,以小鼠肠道通透性、含水量、菌落数、紧密连接蛋白含量等指标评估小鼠肠黏膜屏障功能。结果 糖尿病患者差异基因富集在血小板活化、内皮细胞屏障功能等通路中。db/db小鼠血清sCD40L水平明显升高,肠道组织CD40表达、通透性、含水量、菌落数明显上升,紧密连接蛋白表达下降。西洛他唑干预db/db小鼠后,血清sCD40L、肠道CD40水平明显下降,肠黏膜屏障功能明显改善。结论 西洛他唑可以改善糖尿病小鼠肠黏膜屏障损伤,其保护作用可能与抑制血小板活化相关。 相似文献
3.
本文报道了16例新生血管性青光眼在手术显微镜下行前房内植管术的治疗效果。其中15例作了3～26个月的随访,14例取得了令人满意的疗效。表明这种方法具有组织损伤小,减压效果确切的优点,因此,值得推广。 相似文献
4.
Objective To explore the influence of the acute cauda equina compression on the iumbosacral spinal cord; To clarify the pathologic change of the motor neuron after acute cauda equina compression. Methods 27 canis familiaris were randomly divided into 9 groups （3 in each） ： one for normal group, one for control group, and seven for compression groups. The control group and compressed groups was given operation and the sac made of silica gel was placed under the lamina of L5-6. Water was injected into the sac until their posterior legs paralysis in compressed groups, the animals had been compressed for 4, 8, 12, 24, 48, 72, 168 hours. The control group were not injected water. Cells apoptosis was investigated with the technology of TdT-mediated biotin dUTP nick end-labeling （TUNEL） staining. The Bcl-2 Bax and Caspase-3 protein was investigated by immunohistochemical method. Results TUNEL staining cells in anterior horn presented after compressed 8-12 hours, and at 72 hours the number of positive cells got to maximum, it decreased subsequently after 168 hours. The protein of Bax, Bcl-2 expressed a little in normal motor neuron. The caspase-3 protein didn＇t express in normal ceil. They all reached the peak at 72 hours after compression. Conclusion The apoptosis of motor neuron occurred earlier after eauda equina acute compression. Bax protein restrained Bcl-2 protein then active caspase-3 and conduced apoptosis of motor neuron. 相似文献
5.
对６年前完成乙肝疫苗全程注射的疫苗组１２６名、安慰剂组１３５名５～９岁儿童，经６年观察，随访率控制在９０％或以上。第６年疫苗组抗－ＨＢｓ阳性率和ＧＭＴ明显高于安慰剂组，与第４年相比，无明显差别，Ｔ１２抗体峰值高低和自然加强对维持抗体滴度均起一定作用。疫苗保护率针对ＨＢＶ感染为７８．２％，针对ＨＢｓＡｇ阳转为７７．４％。说明疫苗接种后６年其免疫原性和保护率基本完好，６年内无需复种。但对疫苗效果及抗－ＨＢｃ作为评价指标的意义尚待研究。 相似文献
6.
THE SIGNIFICANCE OF PRE- AND POSTOPERATIVE MEASUREMENT OF SERUM CA242 LEVELS IN PANCREATIC CANCER@陈熹@秦兆寅@纪宗正@黎一鸣l Hag1und C, Lindgren J, Roberts P et al. Tis-sue expression of the tumorassociated antigenCA242 in benign and malignant pancreatic le-sions: a comparison with CA5O and CAl9-9.Br J Cancer, l9891 6O(5): 845
2 Kuusela P, Haglund C, Roberts P. Compari-son of a new tumor marker CA242 with CAl9-9, CA5o in degestive trac[ diseases. B… 相似文献
7.
为了评价黑米糠中铁的可利用程度,本文用Hb恢复法研完了黑米糠铁的相对生物利用率(RBA)。将复制成功的贫血大鼠分为甲、乙、丙、丁和戊五组,在低铁基础饲料基础上,甲组加FeSO_4铁;乙组加糠;丙组加糠和Vc,丁组加糠和熟瘦猪肉,戊组不加为阴性对照组。结果:甲、乙、丙、丁组饲料铁转化入Hb的效率依次为59%、33%、33%和39%,RBA依次为100%,56%、56%和66%。 相似文献
8.
本文探讨了慢性肾功能衰竭患者自身血清对骨髓红系祖细胞的抑制作用及红细胞生成刺激素(erythropoietin EPO)的临床疗效。自身血清加入培养体系与胎牛血清加入组比较,半数病例集落数减少,自身血清用活性炭吸附后,这种造血抑制作用被解除。EPO治疗后的血色素增加程度和自身血清的造血抑制活性呈相关性,可见,如果能设法有效地去除患者体液中的造血抑制因子,EPO的临床疗效就能进一步提高。 相似文献
9.
Ｔｈｅｃｏｒｒｅｌａｔｉｏｎｏｆｍｅｒｉｄｉａｎ ｖｉｓｃｅｒａｉｓｔｈｅｃｏｒｅｏｆｔｈｅｍｅｒｉｄｉａｎｔｈｅｏｒｙｏｆＴｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅＭｅｄｉｃｉｎｅ .Ｓｏｍｅｒｅｓｅａｒｃｈｅｒｓｔｈｉｎｋｔｈａｔｔｈｅｍｏｒｐｈｏｌｏｇｉｃａｌｓｔｒｕｃｔｕｒｅｂａｓｉｓｏｆｔｈｅｃｏｒｒｅｌａｔｉｏｎｏｆｍｅｒｉｄｉａｎ ｖｉｓｃｅｒａｉｓｔｈｅｎｅｒｖｅｓｅｇｍｅｎｔａｒｒａｎｇｅｍｅｎｔｏｆｔｈｅｓｏｍａｔｉｃｔｉｓｓｕｅｓａｎｄｖｉｓｃｅｒａｌｏｒｇａｎｓ .Ｈｏｗｅｖｅｒ ,ｔ… 相似文献