Effects of rosiglitazone on rabbit atherosclerosis

We sought to validate magnetic resonance imaging(MRI) for documenting the effects of rosiglitazone on rabbit atherosclerosis and the possible mechanism by treatment on the lesions.24 New Zealand white rabbits were randomly divided into normal group, control group and treatment group.After 4 weeks, all rabbits underwent MRI.After examination, the number of circulating endothelial progenitor cells(EPCs) and level of lipid, glucose, nitric oxide(NO) and superoxide anion(O-2·) were measured.MRI demonstrated the regression of atherosclerotic lesions by rosiglitazone which has good correlation with histopathology.Treatment not only increased the level of EPCs and NO, but also raised the ability of inhibition of O2-·.MRI is a promising noninvasive technology to detect the effects of therapeutic interventions.Rosiglitazone slows the progression of atherosclerosis that may in part attribute to its improvement of mobilization of EPCs and the reduced oxidative stress.     

冠脉内超声在冠状动脉粥样硬化及介入性治疗中的应用

目的　探讨血管内超声在冠状动脉粥样硬化诊断及评价介入性治疗中的应用价值。方法　应用血管内超声对 41例冠心病患者冠状动脉粥样硬化进行了研究 ,并观察了介入性治疗前后血管形态学改变。结果　血管内超声可清晰显示血管壁的形态结构 ,测量血管面积、管腔面积和面积狭窄率 ;血管内超声对斑块检出的敏感性高于冠脉造影检查 ,血管造影低估冠脉病变的严重程度 ,冠状动脉介入性治疗后血管腔面积和血管面积增加 (P <0 0 5)。结论　血管内超声为定性和定量评价冠状动脉病变和介入性治疗效果提供了可靠的技术     

超声显像在肾肿瘤影像诊断中的作用

报告了我院1986年～1993年临床拟诊断为肾肿瘤,且均行过手术及病理检查的106例患者的各项影像检查诊断结果。诊断正确率:B型超声93.33％(84/90),CT 94.73％(36/38);磁共振成像93.75％(15/16);肾分泌造影82.41％(75/91);肾动脉造影71.43％(5/7);同位素肾动态显像62.50％(25/40)。初步探讨了B超在肾肿瘤诊断中的作用。     

FEMUR SHAPE RECOVERY FROM VOLUMETRIC IMAGES USING 3-D DEFORMABLE MODELS

IntroductionThe rupture of the anterior cruciate ligament( ACL) has become the most common knee in-juries.In operation of ACL reconstruction,thesurgeons have to find the optimal attachmentpoints resulting in a low anisometry of the graft,while preventing impingement between the graftand the femoral notch.Markus Fleute andStéphane lavallée[1] proposed a real- time systemfor computer- assisted ACL surgery.A recentadvance in surgery is minimally invasive tech-nique that can avoid the large…     

血清胱抑素C、高敏C反应蛋白与冠状动脉粥样硬化斑块负荷的关系

目的研究血清胱抑素C(CysC)、高敏C反应蛋白(hs-CRP)与冠状动脉粥样硬化斑块负荷(CAPB)的关系。方法回顾性分析120例因拟诊冠心病而行冠脉造影检查患者的临床资料,应用Gensini积分法对冠心病患者主要冠状动脉狭窄程度定量评估,应用Sullivan提出的方法对CAPB进行评估,并对CysC、hs-CRP与Gensini积分及CAPB的关系进行相关性分析。结果不稳定性心绞痛组患者血清CysC水平相比稳定性心绞痛组明显升高(P<0.05);单因素及多因素分析均显示,血清CysC、hs-CRP水平与CAPB密切相关(P<0.05)。结论血清CysC、hs-CRP水平与CAPB密切相关,可以作为判断急性冠脉事件的预测指标。     

血清妊娠相关血浆蛋白A与急性冠状动脉综合征的临床相关性

目的探讨急性冠脉综合征患者妊娠相关血浆蛋白A水平与高敏C反应蛋白的关系及与动脉粥样硬化斑块稳定性的关系。方法选择急性冠状动脉综合征(ACS)患者43例,稳定性心绞痛(SA)患者25例,对照组15例,进行对比分析,ACS中不稳定性心绞痛(UA)20例,急性心肌梗死(AMI)23例;心绞痛组和对照组于入院次日晨抽取外周静脉血,AMI组于发病12 h内抽取静脉血。采用酶联免疫吸附法(ELISA法)检测血清妊娠相关血浆蛋白(PAPP-A),散射比浊法检测C-反应蛋白(CRP)浓度,进行各组间PAPP-A、CRP含量比较。结果ACS组与稳定型心绞痛组和对照组之间相比,高敏C反应蛋白和妊娠相关血浆蛋白A水平的差异均有显著性(P<0.01);妊娠相关血浆蛋白A水平与高敏C反应蛋白呈正相关(r=0.158);多因素回归分析显示妊娠相关血浆蛋白A水平与高敏C反应蛋白呈正相关直线关系。结论妊娠相关血浆蛋白A水平可作为临床评估冠心病患者病情稳定程度,并进而可能成为评价冠状动脉斑块稳定性的指标之一。     

CLINICAL APPLICATION OF SPECT MYOCARDIAL IMAGING：COMPARISON WITH CORONARY ANGIOGRAPHY AND ECG

ＣＬＩＮＩＣＡＬＡＰＰＬＩＣＡＴＩＯＮＯＦＳＰＥＣＴＭＹＯＣＡＲＤＩＡＬＩＭＡＧＩＮＧ：ＣＯＭＰＡＲＩＳＯＮＷＩＴＨＣＯＲＯＮＡＲＹＡＮＧＩＯＧＲＡＰＨＹＡＮＤＥＣＧＺｏｕＢａｏｍｉｎ；ＭａＹｉ；ＨｕＧｕｏｙｉｎｇ；ＭｅｎｇＸｉａｎｗｅｎ；ＧａｏＹｉ...     

Assessment of levator hiatus by 3D ultrasound volume contrast imaging in normal nulliparas

The ability of 3D ultrasound volume contrast imaging in C-plane (VCI-C) in the assessment of female levator hiatus was analyzed in eighty normal nulliparas. Interoperator variability in levator hiatus measurements was analyzed. The comparison of the axial image of magnetic resonance imaging (MRI) and C-plane image of volume contrast imaging (VCI) in thirty normal nulliparas was also done. It shows that VCI-C can clearly demonstrate the structure and accurately quantitates the size of the levator hiatus. It is reliable, convenient and without contraindication in assessment of female levator hiatus. The technology opens up entirely new modality for assessing female pelvic floor. Foundation item: the Scientific Research Project of Shanghai Municipal Health Bureau (No. 2008083)     

AN EFFICIENT RF COIL FOR GENERATING A CIRCULAR POLARIZED MAGNETIC FIELD

1IntroductionThecreationoftheprincipleofmagneticresonanceimage(MRI)iscreditedtoP.C.Lauterburwhoachivedthefirstimageinl973-It'hasbeendemonstratedthatMRIisabletopro-videthehumanbody'simagewithhighspatialresolutionandhighsensitivitytopathologicalchanges.TheRFcoilisusedtoproduceanddetectradiofrequency(RF)magneticfieldB,.IntheMRIsystemnuclearmagneticresonanceisexcit-edinabodytobeimagedbyapplyingtothebodyanRFmagneticfieldB,perpendiculartoarelativelystrongstaticmagneticfieldB,'IftheRFstreng…     

A rnold-Chiari畸形的诊断与外科治疗

探讨 Arnold- Chiari畸形的 MRI诊断及外科治疗效果。方法　回顾性分析了 1 2例 Arnold- Chiari畸形患者的临床表现、MRI诊断及手术方式和疗效。结果　术前 1 2例患者均经 MRI诊断。 4例行单纯后颅窝及颈 1～ 2椎板减压术 ,8例行后颅窝及颈椎板减压术加同期脊髓空洞—蛛网膜下腔分流术 ,手术有效率为 83%。结论　 MRI是 Arnold- Chiari畸形并脊髓空洞的最佳诊断手段 ;Arnold- Chiari畸形合并较大脊髓空洞时应同期行脊髓空洞—蛛网膜下腔分流术     

基于敏感编码技术磁共振水成像在胃肠道检查中的应用

目的探讨基于敏感编码(SENSE)技术单次激发放射状水成像技术对正常胃肠道解剖结构的显示能力,为水成像技术诊断胃肠道疾病提供正常解剖学基础,并探讨胃肠道疾病的影像学诊断新方法。方法健康自愿者共30例,其中男性19例,女性11例,年龄20-50岁,中位年龄35岁。检查前60 min口服饮用水1 000-1 500 mL,检查前20 min再口服500 mL,扫描前10 min肌注654-2 10 mg。MR水成像(MRH)检查使用PhilipsGyroscan Intera 1.5T超导型MRI,采用SENSE技术相匹配的相控阵线圈及呼吸门控,行单次激发放射状快速自旋回波序列进行胃肠道水成像检查。结果30例均能接受此检查,检查成功率100%。30例水成像图像经盲法评价,优良图像占93%,差图像占7%。其中胃显示率65%,胃黏膜显示清楚占80%;十二指肠显示率80%,空肠显示率59%,空肠直径2-2.5 cm,回肠显示率21%,回肠直径1.5-2.5 cm,小肠黏膜清楚显示占67%;结肠显示率10%,结肠黏膜清楚显示占6%。结论基于SENSE技术单次激发放射状水成像技术对胃、十二指肠及空肠轮廓和黏膜皱襞显示较为清楚,对回肠及结肠轮廓和黏膜皱襞显示较差。单次激发放射状水成像技术结合常规腹部MR检查可以清楚、方便地显示胃肠道的解剖特点,是胃肠道影像学检查的一种新的可供选择的方法。     

肝移植术后肝动脉血栓的介入溶栓治疗分析

目的 探讨肝移植术后肝动脉血栓(HAT)形成后介入溶栓治疗的价值.方法 对160例同种异体肝移植病例,术后采用彩色多普勒超声定期检测肝动脉血流,对怀疑肝动脉血栓形成者行肝动脉造影,确诊4例,均即刻行介入溶栓治疗,其中2例留置肝动脉导管反复持续溶栓治疗.结果 3例介入溶栓治疗后,肝动脉均再通,其中1例因血栓再形成而多次溶栓,2例发生腹腔内少量出血,均经保守治疗痊愈.1例因溶栓失败及腹腔内出血行再次肝移植.结论 肝动脉介入溶栓治疗为HAT的有效方法,留置肝动脉导管持续药物泵入溶栓效果显著.     

Application of Principle Component Analysis and Logistic Regression in Analyzing miRNA Markers of Brain Arteriovenous Malformation

Brain arteriovenous malformation（BAVM） is frequently described as vascular malformation. Although computer tomography（CT）, magnetic resonance imaging（MRI） and angiography can clearly detect lesions, there are no diagnostic biological markers of BAVM available. Current study demonstrated that micro RNA（mi RNA）showed a feasible marker for vascular disease. To find key correlations between these mi RNAs and the onset of BAVM, we carried out chip analysis of serum mi RNAs by identifying 18 potential markers of BAVM. We then constructed a principle component analysis and logistic regression（PCA-LR） model to analyze the 18 mi RNAs collected from 77 patients. Another 9 independent samples were used to test the resulting model. The results showed that mi RNAs hsa-mir-126-3p and hsa-mir-140 are important protective factors, while hsa-mir-338 is a dominating risk factor, all of which have stronger correlation with BAVM than others. We also compared the testing results using PCA-LR model with those using LR model. The comparison revealed that PCA-LR model is better in predicting the disease.     

Wear Mechanisms of Ceramic Inserts in Machining Nickel-Based Superalloy

The performances of ceramic inserts in cutting nickel-based alloy were investigated. A new cutting test-bed was devised and used to deburr. The burr height on the working surface with notch wear in deburring cutting was compared with that in normal cutting. The impact force, impact pressure, and impact frequency of the saw-tooth-shaped chip edge on rake face and cutting edge at different speeds were calculated, and the influence of chip edge on notch wear formation was analyzed. A new tool design for reduci...     

Kinect-based automatic spatial registration framework for neurosurgical navigation

As image-guided navigation plays an important the pre-operative images with the intra-operative patient role in neurosurgery, the spatial registration mapping position becomes crucial for a high accurate surgi- cal output. Conventional landmark-based registration requires expensive and time-consuming logistic support. Surface-based registration is a plausible alternative due to its simplicity and efficacy. In this paper, we propose a comprehensive framework for surface-based registration in neurosurgical navigation, where Kinect is used to auto- matically acquire patient＇s facial surface in a real time manner. Coherent point drift （CPD） algorithm is employed to register the facial surface with pre-operative images （e.g., computed tomography （CT） or magnetic resonance imaging （MRI）） using a coarse-to-fine scheme. The spatial registration results of 6 volunteers demonstrate that the proposed framework has potential for clinical use.     

CT reconstruction with priori MRI images through multi-group datasets expansion

Computed tomography (CT) reconstruction with a well-registered priori magnetic resonance imaging (MRI) image can improve reconstruction results with low-dose CT, because well-registered CT and MRI images have similar structures. However, in clinical settings, the CT image of patients does not always match the priori MRI image because of breathing and movement of patients during CT scanning. To improve the image quality in this case, multi-group datasets expansion is proposed in this paper. In our method, multi-group CT-MRI datasets are formed by expanding CT-MRI datasets. These expanded datasets can also be used by most existing CT-MRI algorithms and improve the reconstructed image quality when the CT image of a patient is not registered with the priori MRI image. In the experiments, we evaluate the performance of the algorithm by using multi-group CT-MRI datasets in several unregistered situations. Experiments show that when the CT and priori MRI images are not registered, the reconstruction results of using multi-group dataset expansion are better than those obtained without using the expansion.     

颈动脉粥样硬化病变的彩色多普勒检查

本文报告用彩色多普勒检测151例颈动脉粥样硬化病变和34例正常人。结果表明颈动脉分叉处是粥样硬化斑块多发部位(62.3%),声像图显示斑块有3种类型(扁平斑、软斑、硬斑)。本组中有6例颈内动脉腔明显狭窄(腔径减少45%以上),狭窄部位显示有镶嵌血流。频谱多普勒分析显示收缩期峰值流速增高和频谱增宽。2例颈内动脉完全阻塞,彩色多普勒显示颈内动脉内无彩色血流。这种方法可用于颈动脉粥样硬化的早期诊断,也对缺血性脑病的预防具有价值。     

MRI的FLAIR序列在颅内出血中的诊断价值

评价 MRI的液体衰减反转恢复序列 ( FLAIR)在颅内出血中的应用价值。方法　回顾性分析 2 8例颅内出血患者 MRI常规序列及 FLAIR序列图像表现。其中脑内出血 2 3例 ,合并蛛网膜下腔出血 1 2例 ,合并脑室出血 4例 ;硬膜下出血 3例 ;肿瘤出血 2例。全部患者均在发病后 3～ 1 0天内行 MR检查。结果　硬膜下出血 ,MR常规扫描及 FLAIR序列均可清晰显示 ,两者之间无显著差异 ;在鉴别亚急性期脑实质内出血是否为肿瘤出血时 ,FLAIR序列具有一定诊断价值 (血肿周围低信号环 ) ;FLAIR序列在显示急性蛛网膜下腔出血和脑室出血中明显优于常规 SE序列。结论　 FLAIR序列在显示急性蛛网膜下腔出血和脑室出血中 ,具有可靠的诊断价值 ;对确定肿瘤出血有一定的参考价值     

肝移植术后并发症的影像学诊断

目的系统分析肝移植术后正常及常见并发症的影像学表现。方法使用Philips Secura螺旋CT扫描仪对50例肝移植术后患者进行检查,CT扫描范围自膈顶至腰3椎体下缘水平,对比剂1.3mL/kg体质量,注药流率2.5mL/s,延迟时间30、60、120s。对拔除T管后出现胆管并发症患者使用Philips Gyroscan NT1.5T磁共振扫描仪检查。使用GE Advance Lp/Lc数字血管造影机,经股动脉穿刺进行肝动脉造影。结果27例肝移植术后患者出现移植肝下积液及右侧胸腔积液,门静脉伴行影像4例,肝动脉吻合口狭窄2例,肝动脉血栓1例,门静脉吻合口狭窄2例,胆管吻合口部位狭窄1例,非吻合口狭窄3例,胆瘘4例,肿瘤复发4例。结论CT、磁共振胆道水成像(MRCP)和数字减影(DSA)可以清晰显示肝移植术后血管、胆管并发症及其他少见并发症。     

MR IMAGING OF THE PANCREAS

Objective To evaluate the ability of showing the pancreatic diseases on various MRI sequences. Methods Eighty-four subjects included 50 normal individuals and 34 patients(22 patients investigated for pancreatic neoplasia and 12 pancreatitis) were presented. The MR protocol included conventional SE T1WI, FSE T2WI, Pre-and post-contrast T1-weighted fat-suppressed and GRE imaging. Results The best diagnostic information was provided by T1-weighted fatsuppressed imaging before and after gadolinium enhancement on 27 of 34 cases with abnormal pan creas, followed by immediately postcontrast GRE images. Precontrast GRE imaging better showed the features of a cute pancreatitis. FSE T2WI obviously exhibited islet cell tumor and metastases of liver from pancreatic adenocarcino ma. Conclusion The standard MR protocol included T1-weighted fat-suppressed image and dynamic GRE imaging.