关于f（p（f））^n的例外值

推广了杨重骏，杨乐等证明的：若ｆ为一超越整函数，ｎ，ｋ为非负整数且ｎ≥２，则ｆ（ｆ＾（ｋ））＾ｎ唯一可能的Ｐｉｃａｒｄ例外值是０这一结果，证明了当ｆ＾（ｋ）易为ｆ的相当广泛的微分多项式时，相应结论仍成立。     

Application of Principle Component Analysis and Logistic Regression in Analyzing miRNA Markers of Brain Arteriovenous Malformation

Brain arteriovenous malformation（BAVM） is frequently described as vascular malformation. Although computer tomography（CT）, magnetic resonance imaging（MRI） and angiography can clearly detect lesions, there are no diagnostic biological markers of BAVM available. Current study demonstrated that micro RNA（mi RNA）showed a feasible marker for vascular disease. To find key correlations between these mi RNAs and the onset of BAVM, we carried out chip analysis of serum mi RNAs by identifying 18 potential markers of BAVM. We then constructed a principle component analysis and logistic regression（PCA-LR） model to analyze the 18 mi RNAs collected from 77 patients. Another 9 independent samples were used to test the resulting model. The results showed that mi RNAs hsa-mir-126-3p and hsa-mir-140 are important protective factors, while hsa-mir-338 is a dominating risk factor, all of which have stronger correlation with BAVM than others. We also compared the testing results using PCA-LR model with those using LR model. The comparison revealed that PCA-LR model is better in predicting the disease.     

Guillain-Barre综合征早期电生理变化及分型再认识

分析了31例Guillain－Barre综合征（GBS）的电生理改变。有14例于病后3周行肌电图检查。早期运动神经传导速度（MCV）异常率为71．01％，主要表现为末端潜伏时（ML）延长，占61．22％，其次为MCV轻度减慢，而感觉神经传导速度（SCV）及肌电图（EMG）对早期GBS的诊断价值有限．但EMG鼻常出现越早，则预后越差。31例电生理特点分型：髓鞘型GBS27例（87．09％），轴索型GBS2例（6．4％），另有2例（6．4％）髓鞘及轴索损害均较重，预后差，故认为可能是两者同时损害的混合型。     

促甲状腺素释放激素对血清甲状腺激素的影响

观察了促甲状腺素释放激素（TRH）兴奋试验对14例未治疗的Graves甲亢（A组），12例治疗后甲功恢复正常的Graves病（B组），10例未治疗的桥本甲亢（C组），13例来治疗甲功正常桥本甲炎（D组）患者及15例健康对照（E组）者血清TSH及T3、T4的影响。发现TSH反应正常组（B、D、E组）血清T3、T4均显著上升，其中MCA和TGA阳性的桥本甲炎组上升幅度最低（D组）。而TSH无反应组（A、C组）血清T3、T4不仅没有上升，反而有所下降，但无统计学差异，下降幅度以MCA、TGA最高的桥本甲亢组最大（C组）。并简要讨论其发生机制。     

Guillain-Barre综合征早期电生理变化及分型再认识

分析了31例Guillain－Barre综合征（GBS）的电生理改变。有14例于病后3周行肌电图检查。早期运动神经传导速度（MCV）异常率为71．01％，主要表现为末端潜伏时（ML）延长，占61．22％，其次为MCV轻度减慢，而感觉神经传导速度（SCV）及肌电图（EMG）对早期GBS的诊断价值有限．但EMG鼻常出现越早，则预后越差。31例电生理特点分型：髓鞘型GBS27例（87．09％），轴索型GBS2例（6．4％），另有2例（6．4％）髓鞘及轴索损害均较重，预后差，故认为可能是两者同时损害的混合型。     

绞股蓝总皂甙与阿霉素、5－氟尿嘧啶联用的抑瘤效果

用患有进展期Ｓ１８０肉瘤的小鼠进行的重复实验证实，绞股蓝总皂甙（ＧＰ）对Ｓ１８０肉瘤有明显的抑制作用，使肿瘤生长延缓，肿瘤坏死比率（肿瘤坏死面积ＴＮＡ／肿瘤总面积ＴＴＡ×１００％）显著增加，瘤周瘤内淋巴细胞、巨噬细胞浸润明显增多，荷瘤鼠脾重明显增加，脾白髓动脉周围淋巴鞘显著增大。阿霉素（ＡＤＭ）或５－氟尿嘧啶（５－Ｆｕ）与ＧＰ联用后，上述各指标均明显优于其分别单用，且ＧＰ能明显减轻阿霉素、５－氟尿嘧啶对骨髓的抑制作用。     

城市交通规划环境影响评价研究

文章分析了单一项目环境影响评价（EIA）的不足,用可持续发展的思想将战略环境评价（SEA）引入城市交通规划环境影响评价,深入研究国内外相关交通规划SEA的理论及实践,对我国今后开展城市交通规划SEA工作提出一些建议。     

雷公藤甲素对小鼠移植皮片存活期MLR及IL-2水平的影响

利用我们已建立的动物模型观察雷公藤甲素对实验鼠移植皮片存活期、ＭＬＲ及ＩＬ－２水平的影响。结果表明,雷公藤甲素联合ＤＳＴ组皮片存活延长,ＭＬＲ和ＩＬ－２水平明显下降（Ｐ＜０．０１,Ｐ＜０．０５）;当其同时联合ＤＳＴ和ＡＴＳ,皮片存活期明显延长（Ｐ＜０．０５）,ＭＬＲ和ＩＬ－２进一步下降（Ｐ＜０．０１）。提示雷公藤甲素在临床器官移植中可能具有一定应用价值。     

一阶椭圆型方程组的某类边值问题

研究一阶椭圆型方程组的某类边值问题，得到了问题的Ｎｏｅｔｈｅｒ性能标，并给出了问题的线性无关解个数ｋ０和可解性条件的个数ｌ０的估计式： （ｋ＋ｋ＇）ｒ≤ｋ０≤（ｋ＋ｋ＇）ｒ，（ｋ＋ｌ＇－１）ｒ≤ｌ０≥（ｋ＋ｌ＇）ｒ。     

RIBA在慢性丙型病毒性肝炎中的应用价值

采用含ＨＣＶ三种抗原（Ｃ_（２２），Ｃ_（３３），Ｃ_（１００））的重组免疫印迹试验（ＲＩＢＡ）检测了７１例抗－ＨＣＶ阳性（ＲＩＡ－２法）的慢性非甲非乙型肝炎患者血清并与ＨＣＶＲＮＡ结果进行了比较。ＲＩＢＡ阳性５６例，可疑８例，对应ＨＣＶＲＮＡ检出率分别为９４．６４％（５３／５６）和３７．５％（３／８），ＲＩＢＡ阴性的７例均未检出ＨＣＶ　ＲＮＡ。ＨＣＶＲＮＡ阳性病例中ＲＩＢＡ多为阳性，可疑仅占５．３６％（３／５６），无１例阴性。可见，ＲＩＢＡ阳性即表示ＨＣＶ感染且存在病毒血症，ＲＩＢＡ可作为第二代ＲＩＡ或ＥＬＩＳＡ查抗－ＨＣＶ的确证实验。     

某类近于凸函数的邻域

引入两类解析函数Ｓｋ（Ｂ）和Ｃｋ（Ｂ），它们分别是星象函数族和凸象函数的推广，给出了确保Ｎｋ（ｆ）包含Ｓｋ（Ｂ）的充分条件（其中ｆ（ｚ）∈Ｃｋ（Ｂ），Ｎδ（ｆ）表示ｆ（ｚ）的δ邻域）其结论推广了一些已知的结果。     

青少年牙周炎与补体第三组份、备解素因子B遗传多态性的相关性研究

用免疫遗传学方法对57例青少年牙周炎（JP）患者与补体第三组份（C3）及备解素因子B（Bf）遗传多态性的相关性进行研究。结果发现，C3FS表型及C3F等位基因与JP里正相关性，C3SS表型及CS等位基因与JP呈负相关性。而Bf表型及等位基因在JP患者中的分布与正常人相比无显著性差异。提示C3的遗传多态性可能与JP的易感性基因有关联，这一结果可能为JP遗传机制的研究提供参考资料。     

改进的LR（1）分析表及其构造算法

提出一个改进的不含GOTO表的LR(1)分析表及其构造算法,基于它的LR(1)语法分析过程不需后入先出栈的辅助。     

Serum renalase inversely related to heart rate variability in dialysis patients

Heart rate variability （HRV） is a noninvasive technique for autonomic nerve activity assessment and an indirect index of adrenergic cardiovascular drive. Renalase is the only known enzyme degrading circulatory catecholamines, participating in regulations of the cardiovascular and sympathetic nervous systems. This study aims at the relation between serum renalase and HRV indexes in dialysis patients. There were 14 hemodialysis （HD） cases, 16 continuous ambulatory peritoneal dialysis （PD） cases, and 16 healthy volunteers enrolled in this study. All the subjects underwent 24 h Holter testing by using a dynamic electocardiogram monitor system to determine HRV parameters, and serum renalase levels were measured. The standard deviation of normal to normal R-R intervals （SDNN, a measure of beat-to-beat variability）, root mean square successive difference （RMSSD）, and the proportion derived by dividing NN50 （the number of interval differences of successive normal to normal intervals greater than 50 ms） by the total number of NN intervals （pNN50） were determined to assess HRV. Both HD and PD patients presented increased maximum heart rate （Max-HR）, minimum heart rate （Min-HR） and average heart rate （Ave-HR）, and presented decreased SDNN, RMSSD and pNN50 relative to healthy controls. Serum levels of renalase were highly negatively correlated with Ave-HR （correlation coefficient r = -0.68, probability P 〈 0.01）, while positively correlated with SDNN （r = 0.64, P 〈 0.01） in both the HD and PD groups. Serum level of renalase was positively correlated with 24 h urine volume （r = 0.73, P 〈 0.01） in PD patients. Renalase might be reciprocally related to HRV and inversely related to Ave-HR in dialysis patients, which will help to probe into renalase＇s physiology and may pave the way to explore renalase replacement therapy in patients with end stage renal disease （ESRD）.     

Containership structural design and optimization based on knowledge-based engineering and Gaussian process

Knowledge-based engineering （KBE） has made success in automobile and molding design industry, and it is introduced into the ship structural design in this paper. From the implementation of KBE, the deterministic design solutions for both rules design method （RDM） and interpolation design method （IDM） are generated. The corresponding finite element model is generated. Gaussian process （GP） is then employed to build the surrogate model for finite element analysis, in order to increase efficiency and maintain accuracy at the same time, and the multi-modal adaptive importance sampling method is adopted to calculate the corresponding structural reliability. An example is given to validate the proposed method. Finally, the reliabilities of the structures＇ strength caused by uncertainty lying in water corrosion, static and wave moments are calculated, and the ship structures are optimized to resist the water corrosion by multi-island genetic algorithm. Deterministic design results from the RDM and IDM are compared with each separate robust design result. The proposed method shows great efficiency and accuracy.     

Receiver autonomous integrity monitoring availability and fault detection capability comparison between BeiDou and GPS

This paper used the statistical methods of quality control to assess receiver autonomous integrity monitoring （RAIM） availability and fault detection （FD） capability of BeiDou14 （Phase II with 14 satellites）, BeiDou （Phase III with 35 satellites） and GPS （with 31 satellites） for the first time. The three constellations are simulated and their RAIM performances are quantified by the global, Asia-Pacific region and temporal variations respectively. RAIM availability must be determined before RAIM detection. It is proposed that RAIM availability performances from satellites and constellation geometry configuration are evaluated by the number of visible satellites （NVS, NVS 〉 5） and geometric dilution of precision （GDOP, GDOP 〈 6） together. The minimal detectable bias （MDB） and minimal detectable effect （MDE） are considered as a measure of the minimum FD capability of RAIM in the measurement level and navigation position level respectively. The analyses of simulation results testify that the average global RAIM performances for BeiDou are better than that for GPS except global RAIM holes proportion. Moreover, the Asia-Pacific RAIM performances for BeiDou are much better than that for GPS in all indexes. RAIM availability from constellation geometry configuration and RAIM minimum FD capability for BeiDou14 are better than that for GPS in Asia-Pacific region in all cases, but the BeiDou14 RAIM availability from satellites are worse than GPS＇s. The methods and conclusions can be used for RAIM prediction and real-time assessment of all kinds of Global Navigation Satellite Systems （GNSS） constellation.     

脆性组氨酸三聚体蛋白和蛋白激酶Ca的表达及其与非小细胞肺癌侵袭、转移的相关性

目的 探讨脆性组氨酸三聚体（FHIT）蛋白和蛋白激酶Ca（cPKCa）在非小细胞肺癌（NSCLC）中的表达及其与NSCLC侵袭、转移的相关性。方法 采用免疫组化PicTure^TM通用型二步法，对41例NSCLC组织和11例肺良性病变组织行FHIT蛋白和cPKCn检测。结果 FHIT蛋白和cPKCa在NSCLC组织中的阳性表达率分别为48．8％和53．7％，在肺良性病变组织中的阳性表达率分别为90．9％和18．20％，均有显著性差异（P〈0．05）；COX比例风险模型生存分析结果显示，FHIT蛋白（P=0．020，RR=2．754）、cPKCa（P=0．022，RR=0．385）具有独立的预后意义。结论 FHIT蛋白和cPKCa表达与NSCLC的发展、侵袭及转移显著相关，可作为判断NSCLC临床预后的参考指标。     

若干平面图的邻强边染色

图Ｇ的一ｋ－正常染色ｆ若使得任意ｕｖ∈Ｅ（Ｇ）满足ｆ（ｕ）≠ｆ（ｖ）,其中ｆ（ｕ）＝ｆ（ｕｗ）│ｕｗ∈Ｅ（Ｇ）,则称ｆ的Ｇ的一ｋ－邻强边染色,简称ｋ－ＡＳＥＣ,并称Ｘａｓ（Ｇ）＝ｍｉｎ（ｋ│存在Ｇ的一ｋ－ＡＳＥＣ）为Ｇ的邻强边色数,研究了唯一圈图和六角系统图的邻强边色数,并提出了一个猜想：对２－连通图Ｇ（Ｖ,Ｅ）（Ｇ（Ｖ,Ｅ）≠Ｃ５）,有△（Ｇ）≤Ｘ′ａｓ（Ｇ）≤△（Ｇ）＋２。     

以孕妇血清PAPP-A及其它妊娠蛋白为指标筛查异常胎儿

测定629例妊娠5～40周孕妇血清妊娠相关血浆蛋白A（PAPP－A）、甲胎蛋白（AFP）和人绒毛膜促性腺激素β亚基（β-hCG）。结果发现：无脑儿孕妇血清PAPP－A水平在妊娠早、中期均明显降低；在妊娠早、中期，胎儿21三体孕妇血清PAPP-A和AFP水平均下降，β-hCG水平升高。胚胎死亡和宫内死胎孕妇血清PAPP－A和β-hCG水平降低。提示此三种妊娠蛋白可在妊娠中期尤其是在妊娠早期作为筛查胎儿异常的重要指标，特别是对胎儿染色体异常和神经管缺陷（NTDs）的筛查。     

Calculation of 3D sensitivity matrix for electromagnetic tomography system using boundary elements and the perturbative approach

Electromagnetic tomography （EMT） is a non-invasive imaging technique capable of mapping the conductivity and permeability of an object. In EMT, eddy currents are induced in the object by the activation coils, and the receiving coils can measure the EMT voltages. When the activation frequency is significantly large, we can treat the metallic targets as electrically perfect conductors （EPCs）. In this situation, a thin skin approximation is reasonable and this type of scattering problem can be effectively treated by the boundary element method （BEM） formulated through integration equations. In this study, we compute three-dimensional （3D） sensitivity matrix between the sensors due to an EPC perturbation. Efficiency improvement is achieved through the utility of scalar magnetic potential. Two EPC objects, one sphere and one cube shaped, are simulated. The results agree well with the H dot H formula. Overall, we conclude that BEM can be used to calculate the 3D sensitivity matrix of an EMT system efficiently. This method is a general one for any shaped objects while the H dot H solution is only capable of producing the response for a small ball.