REGULATION OF PRODUCTION OF PARATHYROID HORMONE－RELATED PEPTIDE （PTHrP） AND EXPRESSION OF ITS mRNA IN A HUMANLIVER－DERIVED CE

ＲＥＧＵＬＡＴＩＯＮＯＦＰＲＯＤＵＣＴＩＯＮＯＦＰＡＲＡＴＨＹＲＯＩＤＨＯＲＭＯＮＥ－ＲＥＬＡＴＥＤＰＥＰＴＩＤＥ（ＰＴＨｒＰ）ＡＮＤＥＸＰＲＥＳＳＩＯＮＯＦＩＴＳｍＲＮＡＩＮＡＨＵＭＡＮＬＩＶＥＲ－ＤＥＲＩＶＥＤＣＥＬＬＬＩＮＥＬｉＨｕｓｏｎｇ；Ｐ...     

Information needs of the continuing urban transportation planning process

Urban transportation is identified as a functional element in the broader context of urban facilities and services. From this point of view, the relative merits of separate information systems for transportation planning and general urban planning, as contrasted to unified systems for all urban management functions, are discussed. The overriding need to make the most effective use of urban resources argues strongly for the unification of urban information systems to the greatest possible extent consistent with the special data requirements of various functional programs. The need to identify and correlate data items for very small areal units and to keep current records of the constantly shifting patterns of social and economic activities in urban areas present difficult, but not insurmountable technical problems. However, the most serious barrier to the development and implementation of comprehensive urban information systems is concluded to be institutional, rather than technical, in nature.     

An application of variance reduction techniques in freeway simulation

Computer simulation models are used in a variety of applications in transportation engineering and have become a prime aid in decision making. The applications range from evaluating traffic control strategies for single intersections to such complex decision processes as evaluating the impact of removing toll facilities at the George Washington Bridge in New York City. While it is widely accepted that simulation offers an unmatchable capability of evaluating alternate control policies, the high variance of the output variable presents a critical problem in such comparative analyses. The simulation models with high output variance must be run longer or replicated many times to achieve a desired precision level, and that corresponds to increased cost of computer resources. This paper describes and illustrates the application of variance reduction concepts that can improve the reliability and efficiency of the simulation experimental process by taking advantage of the simulation model structure. The two variance reduction concepts (common random numbers and antithetic variates) reduce the variance of the output variable by replacing the original sampling procedure with a new procedure that yields the same expected value but with a smaller variance. The application of the variance reduction concept was illustrated using results from experiments with a freeway simulation model. The results indicate that both common random numbers and antithetic variates sampling procedures appreciably reduce the variance of the simulation output measure.     

Global cutting-path optimization considering the minimum heat effect with microgenetic algorithms

This article considers microgenetic algorithms (GAs), which explore in a small population with a few genetic operators, for cutting-path optimization problems. The major difference between GAs and simple genetic algorithms (SGAs) is how to make a reproductive plan for an improved searching technique because of population choice. It is shown that GAs implementation reaches the near-optimal region much earlier than the SGAs approach, and the GAs give a better solution than simulated annealing (SA). The main objective was to determine what temperature distribution can be obtained from the solution of a travelling distributed heat source. The solution of the travelling heat source on nested raw plate provides information about the vertices of each nested part of the raw plate. From the fact that the initial temperature at a piercing point strongly depends on the heat flow which stems from the previous cutting contour, the temperature of all piercing points must be lower than the critical temperature after each cutting of the components of a part. The critical temperature is identified as the mechanical melting temperature of steels. A heuristic back-tracking method is introduced to find the near-optimum cutting path considering the minimum heat effect on deformation. The heuristic back-tracking method is incorporated with the GAs.     

Transient responses of a VLFS during landing and take-off of an airplane

The transient elastic deformation of a pontoon-type very large floating structure (VLFS) caused by the landing and take-off of an airplane is computed by the time-domain mode-expansion method. The memory effects in hydrodynamic forces are taken into account, and great care is paid to numerical accuracy in evaluating all the coefficients appearing in the simultaneous differential equations for the elastic motion of a VLFS. The time-histories of the imparted force and the position and velocity of an airplane during landing and take-off are modeled with data from a Boeing 747-400 jumbo jet. Simulation results are shown of 3-D structural waves on a VLFS and the associated unsteady drag force on an airplane, which is of engineering importance, particularly during take-off. The results for landing show that the airplane moves faster than the structural waves generated in the early stage, and the waves overtake the airplane as its speed decreases to zero. The results for take-off are essentially the same as those for landing, except that the structural waves develop slowly in the early stage, and no obstacle exists on the runway after the take-off of airplane. The additional drag force on an airplane due to the elastic responses of the runway considered in this work was found to be small in magnitude.     

Extensive study on the design loads used for strength assessment of tanker and bulk carrier structures

ClassNK has undertaken wide-ranging basic research covering many aspects related to the safety of ship structures, including design loads, structural analysis, strength assessment of buckling, collapse, and fatigue, and rational corrosion margins to develop new design standards which have transparency and consistency. Among the wide-ranging basic research, this article summarizes the results of extensive work on the design loads used for strength assessments of tanker and bulk carrier structures. The main aim of the research was to develop practical estimation methods of design loads with rational technical backgrounds relating to the actual loads acting on the primary structural members of tankers and bulk carriers. During this study, we proposed the following methodology. Design sea states that closely resemble the actual sea states which are considered to be the most severe for hull structures. Find practical estimation methods for the design sea states by parametric studies using the results of series calculations on representative tankers and bulk carriers. Find practical estimation methods for design regular waves which will result in the same level of stresses as those induced in irregular waves under the design sea states. We also briefly introduced some practical estimation methods for the design loads, such as ship motions, accelerations, hull-girder bending moments, and hydrodynamic pressures that are induced under design regular waves. The findings in this study have been summarized and implemented in the new design standards for tanker and bulk carrier structures.Updated from the Japanese original which won the 2003 SNAJ prize (J Soc Nav Archit Jpn 2002; 191:195–207; 2002; 191:208–220; and 2002; 192:723–733)     

A pseudofield model approach to simulate compartment-fire phenomena for marine fire safety design

In order to prevent the spread of marine compartment fires, it is necessary to understand the governing factors or characteristics of fire-spread phenomena. We present a pseudofield model approach to this problem. We first described a field model of turbulent heat convection based on a standard k – turbulence model. Two-dimensional numerical simulations of a two-linked compartment fire were carried out in order to predict the turbulent convection flow induced by the heat released from the fire. Then a more complicated fire-spread problem of multilinked compartment fires was analyzed by means of a zone model, in which the amounts of oxygen consumption and gas generation were solved by a gas-balance equations system. The effect of threshold conditions on fire propagation and the effect of the thickness of the heat insulation were investigated with numerical simulations.     

At-sea towing of a Mega-Float unit

A huge floating offshore platform (359m long, 60m wide, and 3m deep) was towed into the Pacific Ocean for a validation experiment for a floating airport. Full-scale measurements of towline tension and the bending strain on the upper-deck were made during towing. The measured bending moment agreed well with numerical calculation without taking the draught and towing speed into consideration.