CT肺动脉造影的多参数测量联合心动超声对肺动脉高压程度的预测价值

目的 比较CT肺动脉造影(computer tomography pulmonary angiography, CTPA)联合心动超声对肺动脉高压(pulmonary hypertension,PH)程度的预测价值。方法 回顾性收集我院2013年11月至2021年4月因可疑或确诊PH行右心导管、CTPA和心动超声检查的患者54例。右心导管测量得到肺动脉收缩压(PASP)和肺动脉平均压(PAMP),根据PAMP分为无PH组和轻度、中度、重度PH组。计算机辅助下分割获得肺动脉的三维模型,测量肺动脉的最佳拟合圆直径(Dfit)、最小内切圆直径(Dmin)、最大外切圆直径(Dmax)、水力直径(Dh)、截面积(Area)、周长(Scf),测量右心室最大面积、最大短径。心动超声估测PASP。比较不同PH分组间以上参数的差异,分析以上参数与PASP、PAMP的相关性,纳入具有统计学意义的指标,建立PAMP的3个预测模型(模型1:CTPA肺动脉;模型2:CTPA肺动脉+CTPA右心室;模型3:CTPA肺动脉+CTPA右心室+心动超声),采用受试者操作特性(ROC)曲线比较3个模型的诊断效能。结果 主...     

基于Sugeno模糊模型的CNC机床故障诊断方法

通过将Sugeno模糊模型用于数控机床故障诊断系统的方式,实现了对各个诊断专家诊断结果的模糊综合,消除了诊断专家诊断结论的随意性,保证诊断结论的准确.利用此方法基于诊断专家系统技术可以实现对数控机床的自动诊断,诊断结果准确可靠.     

恒磁场对人白血病细胞生物效应的研究

用流式细胞术探讨了恒磁场对人白血病细胞系HL－60细胞周期的影响，磁场与长春新碱的协同作用。结果表明：恒磁场可以引起HL－60细胞周期的改变，经700mT恒磁场作用后细胞的S％降低；而2260mT的磁场处理则使细胞的S％增加。上述场强的恒磁场均可增加HL-60细胞对长春新碱的敏感性。     

肺间质性病变中肺血管损害的MRI表现和病理对照观察

通过肺间质性病变的动物模型，对肺血管损害的情况进行了MRI和病理学的对照研究。发现在肺间质病变中，MRI表现为T1WI肺血管走行僵直，边缘模糊不清，呈中等稍低的信号阴影。T2WI肺血管周围有边缘不清、模糊的中等偏高信号阴影。其病理学主要表现为肺血管壁结构疏松、水肿，有少许纤维组织增生。肺血管周围的肺间质充血、水肿。肺泡内充满了浆液性渗出，炎细胞浸润。作者认为MRI检查对于相对早期的肺间质性病变中，有关肺血管损害或肺实质损害的观察，不失为一种可行的方法。     

Correlative factors of cognitive impairment in patients with lacunar infarcts I.

Objective To study the relationships between cognitive impairment in patients with lacunar infarcts and quantitative CT measures and to determine the independent correlative factors of cognitive impairment. Methods Neuropsychological examination was conducted for 128 patients with acute lacunar infarct. Number, location, and volume of infarcts, cerebral atrophy index and severity of white matter lesions （WMLs） were measured and recorded. Results The number of lacunar infarcts in cognitive impairment （CI） group was significantly larger than that in cognitive normal （CN） group. Mean width of sulcns and sylvian fissure, index of frontal horn and ventricular-brain ratio （VBR） were significantly different in both groups. There were more patients with 3 grades or 4 grades WMLs in CI group （62%） than those in CN group （22%）. The total volume of lacunar infarcts showed no statistically significant difference. Logistic regression analysis indicated that the number of lacunar infarcts in frontal subcortex and thalamus, the volume of infarcts in anterior periventricular white matter, width of cerebral sulcns and sylvian fissure were correlated with cognitive impairment respectively. Additionally, age and education were correlative factors of cognitive impairment in patients with lacunar infarct. Conclusion Correlative factors of cognitive impairment in patients with lacunar infarct are not merely one feature, but a combination of infarct features （number, location, and volume）, cortical atrophy and host factors （age and education）.     

轴承游隙检测台数据采集与通讯软件系统

介绍了轴承游隙检测台数据采集与通讯软件系统，对系统设计、结构和主要功能特点作了较详细的论述．系统经实际运行验证，其稳定性、可靠性、以及人机交互界面的便捷性和直观性均达到了预期效果．     

Correlative factors of cognitive impairment in patients with lacunar infarcts

Patients with lacunar infarcts are thought tohave an increased risk of cognitive i mpair ment anddementia[1].Cognitive i mpair ment is a predictor ofpoor functional outcome in stroke survivors[2].However,in patients with lacunar infarcts,thepathway leading to cognitive i mpair ment is notclear.According to the lacunar hypothesis,cogni-tive i mpair ment results fromincreased number andvolume of lacunes,especially whenlocated strategi-cally within frontal subcortical loops[3];while Feinet al[4]f…     

OPC客户端设计及其在智能立体车库中的应用

通过对OPC数据访问规范和OPC客户端工作流程的研究,以C 为开发语言实现了基于定制接口的OPC客户端,介绍了OPC客户端中接收器的构建和多线程机制的实现,最后通过在智能立体车库中的应用验证了该客户端的可靠性.     

Classification decision tree algorithm assisting in diagnosing solitary pulmonary nodule by SPECT/CT fusion imaging

Objective To develop a classification tree algorithm to improve diagnostic performances of 99mTc-MIBI SPECT/CT fusion imaging in differentiating solitary pulmonary nodules (SPNs). Methods Forty-four SPNs, including 30 malignant cases and 14 benign ones that were eventually pathologically identified, were included in this prospective study. All patients received 99Tcm-MIBI SPECT/CT scanning at an early stage and a delayed stage before operation. Thirty predictor variables, including 11 clinical variables, 4 variables of emission and 15 variables of transmission information from SPECT/CT scanning, were analyzed independently by the classification tree algorithm and radiological residents. Diagnostic rules were demonstrated in tree-topology, and diagnostic performances were compared with Area under Curve (AUC) of Receiver Operating Characteristic Curve (ROC). Results A classification decision tree with lowest relative cost of 0.340 was developed for 99Tcm-MIBI SPECT/CT scanning in which the value of Target/Normal region of 99Tcm-MIBI uptake in the delayed stage and in the early stage, age, cough and specula sign were five most important contributors. The sensitivity and specificity were 93.33% and 78. 57e, respectively, a little higher than those of the expert. The sensitivity and specificity by residents of Grade one were 76.67% and 28.57%, respectively, and AUC of CART and expert was 0.886±0.055 and 0.829±0.062, respectively, and the corresponding AUC of residents was 0.566±0.092. Comparisons of AUCs suggest that performance of CART was similar to that of expert (P=0.204), but greater than that of residents (P<0.001). Conclusion Our data mining technique using classification decision tree has a much higher accuracy than residents. It suggests that the application of this algorithm will significantly improve the diagnostic performance of residents.     

单纯疱疾病毒胸苷激酶基因/无环鸟苷系统对肝癌的基因治疗

构建逆转录病毒载体（LNHcTL），将单纯疱疹1型病毒胸苷激酶（HSV1-TK）基因导人人肝癌SMMC7721细胞，用其建立无环鸟苷（ACV）诱导的裸鼠皮下人肝癌移植性肿瘤治疗模型，并将产生复制缺陷型逆gli录病毒的小鼠包装细胞（PA317／LNHcTL）注入肝癌患者的瘤块内，静脉注射ACV。结果发现用药组裸鼠移植瘤逐渐消退，平均瘤重低于对照组6倍；患者肝内的癌块有明显的缩小。表明这种经ACV诱导HSV1－TK基因表达的方法可能成为人肝癌基因治疗的一种有效手段。单纯疱疾病毒胸苷激酶基因/无环鸟苷系统对肝癌的基因治疗@陈葳$西安第一附属…