Recent progress in the genetics of generalized vitiligo

Vitiligo is an acquired disease characterized principally by patchy depigmentation of skin and overlying hair. Generalized vitiligo (GV), the predominant form of the disorder, results from autoimmune l...     

Investigation of model and parameter uncertainty in water quality models using a random walk method

A mathematical model to predict the effect of chemical spills in the Forth estuary in Scotland has been in use for many years. The model, based on the random walk method, predicts chemical concentrations in the estuary waters and estimates the elapsed time before the dilution is sufficient to render the spill harmless (making use of a toxicity measure such as the LC50 or a water quality standard). The model gives a deterministic result without any estimate of the uncertainty. Field studies using tracer dyes to measure the horizontal and vertical mixing rates in the estuary show that these rates vary over time. The literature on turbulent diffusion includes modelling applications using different parameterisations of the mixing process. This paper investigates the uncertainties in predicted concentrations due to model parameterisation of horizontal mixing and due to the variability in the measured mixing rates determined from surveys in the estuary. Estimates of the range of concentrations for a specific spill scenario are presented.The study shows that model formulation and parameter uncertainty are both important factors in estimating the uncertainty in model predictions. The uncertainty caused by the variations with time found in the measured mixing rates is found to be of similar magnitude to the differences in concentration resulting from using three different methods for modelling the horizontal mixing in the estuary. Uncertainties associated with model formulation could be reduced if a small number of longer timescale (e.g. 24 h) dispersion experiments were available. In addition, further data from short-term (3 h) dispersion experiments would give a better understanding of the distribution of mixing coefficients and how the mixing relates to other parameters such as tidal range and wind speed and direction.     

The onset of biological winter in the eastern Weddell Gyre (Antarctica) planktonic community

Data on hydrography, phyto- and zooplankton, obtained on a transect along the 0° meridian during the Winter Weddell Gyre Study, June 1992, revealed peculiarities of the early winter situation in the eastern Weddell Gyre. The vertical distribution and developmental stage composition of Rhincalanus gigas, Calanoides acutus, Calanus propinquus and krill, Euphausia superba larvae, were a good index for a general assessment of the seasonal condition of the plankton communities. There were five zones differing in seasonal situation: (1) The Polar Front and the southern ACC (not studied in detail), (2) The Weddell Front, (3) The Weddell Gyre interior, (4) The Maud Rise area, and (5) The Coastal Current zone. In the Weddell Front, the planktonic community resembled an autumnal situation with moderate phytoplankton biomass; the overwintering stock of copepods was not completely formed and the occurrence of calyptopes larvae of E. superba indicated that krill continued to reproduce until May. In the Weddell Gyre interior, a typical winter plankton community was found even before sea ice had formed. The specific hydrographic regime of the Maud Rise (governed by the mesoscale circulation over the seamount) support the late autumn conditions similar to the Weddell Front (but without early krill larvae). The plankton of the Coastal Current was a winter community. We conclude that in the eastern part of the Weddell Front (compared to the western part) seasonal development of both phytoplankton and herbivorous zooplankton is delayed in spring but prolonged in late autumn. Furthermore, it appears that the Weddell Sea ecosystem exhibits a much higher degree of spatial and temporal variability than thought before. This may have an impact on seasonal pattern of organic carbon transport from the pelagic realm to deeper water layers and to the sediment.     

Chlorophyll estimation in the Southeastern Mediterranean using CZCS images: adaptation of an algorithm and its validation

Region-specific algorithm to derive chlorophyll concentration from Coastal Zone Color Scanner (CZCS) images was adopted following field measurements in the Southeastern Mediterranean Sea, in June 1992. Reflectance in the range 400 to 700 nm, chlorophyll concentration and seston dry weight were measured simultaneously at 21 stations. The optical model used based on algorithm for Case I waters, using shipboard simulation of CZCS channels for adaptation of parameters. The resulting model was validated with an independent data sets from series of cruises in the Southeastern Mediterranean (1981–1984). Concurrent CZCS images were used for retrieval of the radiance ratio Channel 1/Channel 3, for each station. The resulting ratios were then used to calculate chlorophyll concentrations. A comparison between those calculated concentrations and the actual chlorophyll measurements showed that an estimation error of chlorophyll as low as 0.013 mg m⁻³ was achieved.     

Linking mercury exposure to habitat and feeding behaviour in Beaufort Sea beluga whales

Mercury (Hg) levels in the Beaufort Sea beluga population have been increasing since the 1990's. Ultimately, it is the Hg content of prey that determines beluga Hg levels. However, the Beaufort Sea beluga diet is not understood, and little is known about the diet Hg sources in their summer habitat. During the summer, they segregate into social groups based on habitat use leading to the hypothesis that they may feed in different food webs explaining Hg dietary sources. Methyl mercury (MeHg) and total mercury (THg) levels were measured in the estuarine-shelf, Amundsen Gulf and epibenthic food webs in the western Canadian Arctic collected during the Canadian Arctic Shelf Exchange Study (CASES) to assess their dietary Hg contribution. To our knowledge, this is the first study to report MeHg levels in estuarine fish and epibenthic invertebrates from the Arctic Ocean. Although the Mackenzie River is a large source of Hg, the estuarine-shelf prey items had the lowest MeHg levels, ranging from 0.1 to 0.27 μg/g dry weight (dw) in arctic cisco (Coregonus autumnalis) and saffron cod (Eleginus gracilis) respectively. Highest MeHg levels occurred in fourhorn sculpin (Myoxocephalus quadricornis) (0.5 μg/g dw) from the epibenthic food web. Beluga hypothesized to feed in the epibenthic and Amundsen Gulf food webs had the highest Hg levels matching with high Hg levels in associated food webs, and estuarine-shelf belugas had the lowest Hg levels (2.6 μg/g dw), corresponding with the low food web Hg levels, supporting the variation in dietary Hg uptake. The trophic level transfer of Hg was similar among the food webs, highlighting the importance of Hg sources at the bottom of the food web as well as food web length. We propose that future biomagnification studies incorporate predator behaviour with food web structure to assist in the evaluation of dietary Hg sources.     

A numerical study of stochastic larval settlement in the California Current system

Key to the predictive understanding of many nearshore marine ecosystems is the transport of larvae by ocean circulation processes. Many species release thousands to billions of larvae to develop in pelagic waters, but only a few lucky ones successfully settle to suitable habitat and recruit to adult life stages. Methodologies for predicting the larval dispersal are still primitive, and simple diffusive analyses are still used for many important applications. In this study, we investigate mechanisms of larval dispersal using idealized simulations of time-evolving coastal circulations in the California Current system with Lagrangian particles as models for planktonic larvae. Connectivity matrices, which describe the source-to-destination relationships for larval dispersal for a given larval development time course, are used to diagnose the time–space dynamics of larval settlement. The resulting connectivity matrices are shown to be a function of several important time scales, such as the planktonic larval duration, the frequency and duration of larval release events and inherent time scales for the coastal circulations. Many important fishery management applications require knowledge of fish stocks on a year-to-year or generation-to-generation basis. For these short time scales (typically less than 1 year), larval dispersal is generally far from a simple diffusive process and the consideration of the stochastic and episodic nature of larval dispersal is required. This work provides new insights into the spatial–temporal dynamics of nearshore fish stocks.     

Sea level and Eddy Kinetic Energy variability in the Bay of Biscay, inferred from satellite altimeter data

Twelve years (1993–2005) of altimetric data, combining different missions (ERS-1/2, TOPEX/Poseidon, Jason-1 and Envisat), are used to analyse sea level and Eddy Kinetic Energy variability in the Bay of Biscay at different time-scales. A specific processing of coastal data has been applied, to remove erroneous artefacts. Likewise, an optimal interpolation has been used, to create a series of regional Sea Level Anomaly maps, merging data sets from two satellites.The sea level presents a trend of about 2.7 mm/year, which is within the averaged values of sea level rise in the global ocean. Frequency spectra show that the seasonal cycle is the main time-scale affecting the sea level and Eddy Kinetic Energy variability. The maximum sea level occurs in October, whilst the minimum is observed in April. The steric effect is the cause of this annual cycle. The Northern French shelf/slope presents intense variability which is likely due to internal tides. Some areas of the ocean basin are also characterised by intense variability, due to the presence of eddies.The Eddy Kinetic Energy, in turn, is higher from December to May, than during the rest of the year and presents a weak positive trend from April 1995 to April 2005. Several documented mesoscale events, occurring at the end of 1997 and during 1998, are analysed. Altimetry maps prove to be a useful tool to monitor swoddy-like eddies from their birth to their decay, as well as the inflow of seasonal slope water current into the southeastern corner of the Bay of Biscay.     

Study of damaged ship motions taking into account floodwater dynamics

This paper presents an application of shallow water theory to describe the motion of floodwater inside a rolling ship in damage condition. The time domain theoretical approach to the coupled problems of ship and water inside compartment motions is briefly described, including the method used to solve for the water motion characteristics and forces exerted on the ship. This approach is applied to the study of the behaviour of a passenger Ro–Ro ship in regular beam seas and numerical results are given for the intact and damaged conditions. Comparison is made with experimental results. For the damaged condition, the characteristics of the floodwater motion are studied in the time domain for a number of different wave frequencies. The shape of the free-surface and phase of water motion in relation to the ship roll motion are shown for several wave frequencies. The dynamic floodwater roll moment is also shown and compared with the static roll moment (flat horizontal free surface), allowing the conclusion that the dynamic roll moment is much larger than the static roll moment, for high wave frequencies, and is in phase opposition in relation to the roll motion.     

Marine engineers’ training: Educational assessment for an engine room simulator

Qualitative upgrading of the educational process at university level marine education depends largely on the instructive value of the trainers’ educational software. Marine education software has developed out of a certain initial implementation in an equivalent manner to which the programs of practice and training have been applied in cases of simulations and programming environments. In most cases, educational software categories have developed without taking into consideration any special pedagogical theory.     

Flag state performance: An empirical analysis

Based on data available in mid-2006, the five cooperating international institutions of shipping — BIMCO, Intertanko, Intercargo, ICS, and ISF — produced a summary of factual information on 106 flag states. These international institutions intentionally avoided drawing conclusions on underperformance. This paper extends this assessment allowing for an in-depth empirical assessment of flags performance. Towards this end, the analysis uses weight factors reflecting the importance that an operator might wish to attach on the different variables before making his flag choice, and seeks to statistically (un)group ‘conventionally’ grouped flag states performance. The paper also examines whether IMO membership and/or active participation in the IMO is associated with a greater compliance of a flag-state to safety and relevant environment rules and thus to a better performance. The findings challenge the classic outright categorization of national flags as good performing ones and of commercial flags as those performing badly. The findings also support the suggestion that an active IMO participation, rather than a simple membership, enhances flag performance.