熔融石英砂动力特性动三轴试验

为探究振动荷载作用下熔融石英砂液化破坏过程中动变形和动强度变化规律, 促进透明土技术在岩土工程动力特性可视化模型试验中的推广和应用, 对构成透明砂土骨架结构的典型粒径(0.5~1.0 mm)熔融石英砂开展饱和试样动三轴试验; 研究了不同围压、加载频率和动应力比等试验条件下熔融石英砂试样的累积轴向应变、动孔压发展模式、动应力衰减、动弹性模量和阻尼比的变化规律, 并将试验结果与相同级配的标准砂进行了对比。分析结果表明: 熔融石英砂累积轴向应变随动应力比的增大呈现出由稳定型向破坏型转变的趋势, 加载频率为0.5~1.5 Hz时, 临界动应力比为0.150~0.175, 小于标准砂的0.200~0.225;升高围压、增大动应力比、降低加载频率会加快试样塑性应变累积, 缩短液化破坏时间; 熔融石英砂孔压发展模式随围压增大逐渐由Seed孔压模型向指数型过渡, 增大加载动应力会加剧液化破坏后孔压的振动幅度; 相同动应力比下, 熔融石英砂与标准砂的动应力与动应变呈现线性相关, 在围压大于200 kPa时, 二者动应力衰减幅度随围压的增大而逐渐减小; 熔融石英砂的动弹性模量和阻尼比表现为线性关系, 动弹性模量随动应变的增大呈现出双曲线型减小的趋势, 并随围压的增大而增大; 阻尼比随动应变的增加先增大后基本稳定在0.22, 发展曲线受围压影响较小。      

低剂量水稳碎石混合料成型工艺对比研究

基于同一级配低剂量半刚性基层混合料,本文分析了振动法和击实法两种方法成型试件的强度和力学特点。并通过实体工程对试验结果进行了验证。     

上海市道路隧道结构设计标准综述

通过调研和总结上海已建15座盾构隧道的设计资料,对现有隧道存在的病害进行了归类分析,提出了隧道病害的预防与治理措施;对明挖段的围护设计选型、结构工程规模和盾构隧道几何设计参数进行了统计分析,提出了明挖接线段围护结构选型及插入比的建议,明确了明挖结构的计算模型和计算参数;对已建盾构隧道的埋深、最小曲线半径、最小线间距、最大坡度等几何参数进行了详细分析,总结出了工作井平面尺寸的确定方法和盾构进出洞的关键技术。     

Travel time estimation oriented freeway sensor placement problem considering sensor failure

Optimal sensor placement on freeway corridor is of great interest to transportation authorities. However, current traffic sensors are easily subject to various failures. Therefore, it is necessary to incorporate sensor failure into the optimal sensor placement model. In this article, a two-stage stochastic model is proposed for the purpose of travel time estimation on freeway corridor. To balance the effectiveness and reliability, a stochastic conditional value at risk (CVaR) model is also proposed. Since both models are too complicated, a customized genetic algorithm is developed. Numerical experiments show that considering sensor failure makes a significant performance improvement in the sensor placement pattern. Sensitivity analysis is also applied to investigate the impact of a number of allowable sensors and different traffic sensor failure probability.     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响

目的观察沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响。方法实验用深部X线治疗机,每次以3000 cGy的剂量,照射两次,造成大白鼠臀部放射性皮肤损伤。待动物症状明显后,将Ⅱ度皮肤损伤的动物随机分为6组,即阴性对照组、沙棘果油高剂量组、沙棘果油低剂量组、沙棘籽油高剂量组、沙棘籽油低剂量组以及阳性对照组。沙棘果油及籽油高剂量组,每天在损伤部位涂药两次,而其低剂量组每天涂药一次,阴性对照组每天涂灭菌的注射用水一次,阳性对照组每天涂Solcoseryl-Jelly软膏一次。结果肉眼观察结果显示,连续用药10d后,沙棘果油、籽油及Sol-coseryl-Jelly组动物的局部红斑、水肿明显减轻,创面分泌物明显减少,用药2周后,上述症状明显消退,与阴性对照组比较,明显好转;另外,沙棘果油、籽油及Solcoseryl-Jelly组的创面愈合时间明显缩短。光学显微镜观察结果显示,沙棘果油、籽油及Solcoseryl-Jelly组的皮肤损伤明显减轻,炎症反应亦明显减轻,创面修复明显。电子显微镜观察结果显示,阴性对照组的超微结构明显受损,而沙棘果油、籽油及Solcoseryl-Jelly组的损伤明显减轻。结论沙棘果油及沙棘籽油对大鼠放射性皮肤损伤有明显的治疗作用。     

姜黄素促进RAW264.7源性M1巨噬细胞向替代激活M2表型极化

目的观察姜黄素对LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)极化的影响及机制。方法不同浓度姜黄素(6.25、12.5、25μmol/L)干预LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)12h,同时再加入20μmol/L GW9662与25μmol/L姜黄素共同干预LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)12h,采用Real-time PCR、ELISA及Western blot方法检测IL-1β、IL-6和M2表型标志分子KLF4、FIZZ1、MGL1、PPARγ的表达,及阻断PPARγ后KLF4和FIZZ1的表达。结果不同浓度姜黄素均能上调LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)的M2标志分子的表达,并且抑制炎症因子IL-1β和IL-6的分泌;阻断PPARγ后,RAW264.7巨噬细胞源性M1表型巨噬细胞表达M2标志分子下调。结论姜黄素通过活化PPARγ促进LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)向M2表型极化。     

护栏高度变化对防撞能力影响研究

护栏高度由于路面加铺罩面而降低,使得其安全防护性能受到影响。利用LS-DYNA有限元分析软件对不同高度下波形梁护栏进行了碰撞仿真实验,量化分析了护栏高度降低与其安全防护能力关系,确定了护栏防撞性能不能满足规范要求的临界高度值。对沿海高速公路原有护栏提出改造方案,并运用计算机仿真证明其符合规范规定。     

我国载人深渊器的发展策略及当前进展

文中简要介绍了载人深渊器的概念;阐述了我国研制载人深渊器的意义;总结了"蛟龙号"的经验与启示;提出了我国载人深渊器的发展策略并综述了目前所取得的进展.