基于准平面假定的外贴CFRP板加固宽缺口混凝土梁刚度研究

宽缺口混凝土梁是为研究CFRP板与混凝土界面特性而构造一种新型混凝土梁.为分析该新型梁的变形与刚度特性,对11根外贴CFRP板加固的各类混凝土梁进行静载试验,并对其变形刚度进行详细的测试和研究.基于FRP类材料加固混凝土梁应变协调的准平面假定并考量CFRP板的刚度贡献,对加固后宽缺口混凝土梁的刚度计算公式进行理论推导,并将理论公式计算结果与实测结果进行比对.研究结果表明:外贴CFRP混凝土梁的刚度有小幅度提高,CFRP板能延缓裂缝的发展,减小梁的变形.     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响

目的观察沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响。方法实验用深部X线治疗机,每次以3000 cGy的剂量,照射两次,造成大白鼠臀部放射性皮肤损伤。待动物症状明显后,将Ⅱ度皮肤损伤的动物随机分为6组,即阴性对照组、沙棘果油高剂量组、沙棘果油低剂量组、沙棘籽油高剂量组、沙棘籽油低剂量组以及阳性对照组。沙棘果油及籽油高剂量组,每天在损伤部位涂药两次,而其低剂量组每天涂药一次,阴性对照组每天涂灭菌的注射用水一次,阳性对照组每天涂Solcoseryl-Jelly软膏一次。结果肉眼观察结果显示,连续用药10d后,沙棘果油、籽油及Sol-coseryl-Jelly组动物的局部红斑、水肿明显减轻,创面分泌物明显减少,用药2周后,上述症状明显消退,与阴性对照组比较,明显好转;另外,沙棘果油、籽油及Solcoseryl-Jelly组的创面愈合时间明显缩短。光学显微镜观察结果显示,沙棘果油、籽油及Solcoseryl-Jelly组的皮肤损伤明显减轻,炎症反应亦明显减轻,创面修复明显。电子显微镜观察结果显示,阴性对照组的超微结构明显受损,而沙棘果油、籽油及Solcoseryl-Jelly组的损伤明显减轻。结论沙棘果油及沙棘籽油对大鼠放射性皮肤损伤有明显的治疗作用。     

护栏高度变化对防撞能力影响研究

护栏高度由于路面加铺罩面而降低,使得其安全防护性能受到影响。利用LS-DYNA有限元分析软件对不同高度下波形梁护栏进行了碰撞仿真实验,量化分析了护栏高度降低与其安全防护能力关系,确定了护栏防撞性能不能满足规范要求的临界高度值。对沿海高速公路原有护栏提出改造方案,并运用计算机仿真证明其符合规范规定。     

我国载人深渊器的发展策略及当前进展

文中简要介绍了载人深渊器的概念;阐述了我国研制载人深渊器的意义;总结了"蛟龙号"的经验与启示;提出了我国载人深渊器的发展策略并综述了目前所取得的进展.     

FD46TB发动机电控系统

为满足汽车更严格的尾气排放标准,许多客车厂已开始批量使用电控柴油发动机。这些发动机电路控制差异较大。本文介绍FD46TB发动机的控制系统。     

轿车与6岁儿童行人不同方位碰撞中下肢损伤分析

Euro NCAP发布的行人模型认证技术公告TB024的最新版本对6岁儿童行人模型认证提出了单独要求,旨在加强对儿童行人的保护.本研究应用符合Euro NCAP技术公告(TB024)规定并且具有详细解剖学结构的6岁儿童行人有限元模型,设置了4组不同方位行人-汽车碰撞仿真试验,以探究不同碰撞方位下的儿童下肢损伤机理.结果...     

6缸柴油机改用单排气总管的模拟计算与实验研究

某车用柴油机改型为船用,排气管相应地由风冷改成水冷。本文对原机进行了模拟计算和实验校核。在此基础上,对改用水冷单排气总管的机型进行模拟计算,对排气管结构,进、排气阀正时对柴油机运行的影响进行了分析。实验研究表明：采用单排气总管增压系统,新的机型能够满足功率要求,在低工况下燃油经济也较好。     

小汽车限行政策实践评述与反思

为解决小汽车保有量增加过快引发的交通相关问题,国内外许多城市开始实施限行政策.本文梳理总结了国内外城市限行政策的演化进程,发现尽管限行政策对缓解交通拥堵和改善空气污染有一定的作用,但不同城市的限行措施和限行效果也各有差异,出行者的一些规避限行的行为可能会对限行政策的实施效果产生一定的影响.