AMP激活的蛋白激酶对大鼠弥漫性轴索损伤后神经元自噬的调节

目的研究AMP激活的蛋白激酶(AMPK)信号通路在弥漫性轴索损伤(DAI)大鼠脑组织中的表达,探讨AMPK对DAI后神经自噬的调节机制。方法大鼠头颅瞬间旋转损伤法建立DAI模型,免疫蛋白印迹法检测造模后1、3、7d大脑皮层和海马AMPK、磷酸化AMPK(p-AMPK)、Beclin1、LC3Ⅰ/Ⅱ、p62蛋白的动态表达,并与正常组和假手术组比较。侧脑室给予AMPK抑制剂Compound C及激活剂AICAR,检测药物干预对大鼠神经自噬相关蛋白表达的影响,并与DAI组和vehicle组进行比较。结果与正常组和假手术组相比,DAI 1d后脑内AMPK信号通路激活,3d后脑内自噬水平上调;Compound C可以减少AMPK磷酸化激活同时下调脑内的自噬水平,AICAR可以增高AMPK磷酸化水平上调神经自噬改善神经功能损伤。结论大鼠DAI后AMPK的激活可以上调神经自噬的水平,对DAI后的神经保护有重要意义。     

卷管铺设过程的时域动力分析

卷管法是海底管道铺设中的一种重要方法,由于其铺设过程涉及很多装备,因而管道的受力过程复杂。管道的上卷过程会使管道发生塑性变形并引起残余曲率,上卷过程造成的变形需要在退卷过程中进行校直,这个过程中的缠绕和校直引起的塑性变形,对管线造成的损伤不可忽视。首先介绍卷管式铺管法的铺设原理,然后利用有限元分析软件ABAQUS模拟管道上卷和退卷的动态过程,最后研究卷管铺设上卷和退卷过程中管道的轴向应变历史和应力应变关系以及管道弯曲曲率、截面椭圆率变化历史。结果表明,管道在经过卷筒、校准器、校直器时产生很大的弯曲曲率和截面椭圆率。     

应用三维千斤顶精确安装海上大型预制箱梁施工技术

随着码头建设逐步迈向深水化、外海化,带动上部预制梁板向大型化发展,但外海海况恶劣,传统起重船安装工艺无法保证精度。以青岛港董家口港区40万t矿石码头为例介绍外海精确安装500 t预制箱梁的整套施工工艺,主要包括采用海上塔吊、三维千斤顶与调梁扁担结合使用等。该工艺的成功实施,为海上大型预制箱梁的安装开辟了新思路。     

庄河石城岛海域的泥沙运动对港口平面布置的影响

分析了庄河石城岛海域的泥沙运动规律,计算了波浪破碎水深、泥沙起动水深和底沙起动流速,论证庄河石城岛天然深槽的动力成因。确定了港区规划平面布局的基本原则,分析防沙堤布置、规划填海界限等关键参数;通过经验公式、泥沙数模和类似港址类比等方法综合论证港区回淤量级。     

海工产品拖拉滑移装置设计

为解决海工产品移位的难题,对海工产品的拖拉滑移技术进行研究,提出了一种拖拉滑移装置。该装置将定滑轮组集成于专用滑块上,即可进行海工产品的拖拉滑移作业。实际应用效果较好。     

潜水环境噪声数据库设计与开发

随着人类水下活动和实验行为的增多,越来越多的应用需要借助水声探测技术和水声通信技术,而在潜水环境中,环境噪声是以上技术的重要制约因素。因而,了解相应海域的环境噪声特性并建立环境噪声数据库,将有助于该海域的航运、测绘、通信等水声技术的应用与发展。本文针对以上需求,提出一种噪声建模方法,并根据该方法设计和研究相应的潜水环境噪声数据库。实验证明本文提出的方法具有一定的可行性。     

镇江地区非饱和膨胀土边坡在降雨入渗下的稳定性分析

针对非饱和膨胀土边坡在降雨入渗下的稳定问题,结合镇江地区非饱和土的室内试验,对边坡的动态过程进行分析.分析了不同雨强、地下水位情况下降雨入渗的情况,对降雨入渗下的非饱和土边坡进行渗流场的数值模拟,得到非饱和土边坡降雨入渗下的若干规律,以及随降雨发展边坡稳定性的变化情况,为镇江地区的非饱和膨胀土边坡的稳定分析提供依据.     

Sub‐optimal decision‐making and the transportation problem

A modification to the transportation problem is outlined that aims to improve the quality of predictions of trip matrices, and at the same time, allow some behavioural and economic insights. A framework is suggested within which this modification may be made and a suitable statistic and iterative process are described. A simple example demonstrates the validity of the modification and suggests some areas of difficulty with the approach.     

Rapid first-stage tests of on-ship infection

Protection against on-ship infectious disease—whether due to mishap or to harmful purpose—faces special situational problems. Sometimes, when infection levels on board have reached threshold levels, emergency actions are required. Often, the most thorough strategies for responding to threat are not feasible. A rapid first-stage test (RFT) is a fast, minimally invasive procedure used to rule out from possible infection a large percentage of an infection-threatened group. Prevention and control of on-ship infection need to combine various interconnected tactics. When timely criterion tests are not possible, the medical team must adopt fast alternative measures. The methods used to summarize protection against on-ship infectious agents included a scientific literature review and a web search. The fields of the review were maritime, health, and technology sources. Special attention was paid to material dealing with risks and threats of on-ship penetration by infectious agents, on-ship infection prevalence thresholds, and rapid diagnostic screens. The Bayes rule and the law of large numbers were applied to the analysis, for large on-ship populations, of RFT indications of crossing of an infection prevalence threshold. The increasing risk of serious on-ship infection—either accidental or purposeful—calls for a multi-layered protection approach. RFTs are a key part of the outer layer of such a defense. Well-designed and well-administered RFTs provide several advantages for defense against on-ship infection: low-cost, non-invasive, fast, and focuses on a drastically smaller number of infection possibilities.     

基于谐波平衡法的Broyden网格分区迭代算法

在融合Broyden算法与网格分区思想的基础上,提出一种基于谐波平衡法且适用于对间隙型非线性动力系统进行频响特性分析的新型Broyden网格迭代算法.阐述了Broyden网格迭代算法的基本思想与计算流程.对决定该算法有效性的Broyden算法发散特性及不完整变量循环迭代过程等关键特性进行了分析与讨论.通过与相关文献采用的二分法所得的同等条件下的计算结果进行对比,证明该算法比二分法具有更好引导性与更全面的求解能力.通过网格分区的引导,该方法避免了数值迭代方法中普遍面临的迭代初值的盲目选择问题,为基于谐波平衡法全面考察间隙型非线性动力系统的频响特性提供了新途径.