Simulation and analysis of vehicle stability based on ADAMS/CAR differential brake

To improve the braking safety of automobiles, the author studied the effect of differential brake on the stabilities. To analyze the mechanical characteristics of differential brake, automotive subsystem models were built by applying ADAMS/CAR, and automotive mechanics simulation model was built by setting the main subsystems such as body, engine and brake. The simulation model studied the distribution mode of three kinds of differential brake, and beeline braking stability and turning braking stability were simulated. It shows that differential brake can amend turning shortage of automobile brake and improve its braking stability, but the effect of automobile mass on its braking stability is great. So the distribution mode of braking force and the effect of mass change should be considered while differential brake is applied.     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响

目的观察沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响。方法实验用深部X线治疗机,每次以3000 cGy的剂量,照射两次,造成大白鼠臀部放射性皮肤损伤。待动物症状明显后,将Ⅱ度皮肤损伤的动物随机分为6组,即阴性对照组、沙棘果油高剂量组、沙棘果油低剂量组、沙棘籽油高剂量组、沙棘籽油低剂量组以及阳性对照组。沙棘果油及籽油高剂量组,每天在损伤部位涂药两次,而其低剂量组每天涂药一次,阴性对照组每天涂灭菌的注射用水一次,阳性对照组每天涂Solcoseryl-Jelly软膏一次。结果肉眼观察结果显示,连续用药10d后,沙棘果油、籽油及Sol-coseryl-Jelly组动物的局部红斑、水肿明显减轻,创面分泌物明显减少,用药2周后,上述症状明显消退,与阴性对照组比较,明显好转;另外,沙棘果油、籽油及Solcoseryl-Jelly组的创面愈合时间明显缩短。光学显微镜观察结果显示,沙棘果油、籽油及Solcoseryl-Jelly组的皮肤损伤明显减轻,炎症反应亦明显减轻,创面修复明显。电子显微镜观察结果显示,阴性对照组的超微结构明显受损,而沙棘果油、籽油及Solcoseryl-Jelly组的损伤明显减轻。结论沙棘果油及沙棘籽油对大鼠放射性皮肤损伤有明显的治疗作用。     

WWOX蛋白在非小细胞肺癌中的表达及其临床意义

目的 探讨WWOX(WW domain-containing oxidoreductase)基因在非小细胞肺癌组织中的表达及其临床意义.方法 用免疫组化方法检测50例鳞癌、31例腺癌及20例癌旁正常组织中WWOX基因蛋白的表达,并分析其与各临床病理指标之间的相关性.结果 WWOX基因在72.8%的非小细胞肺癌中失表达或表达减少,而在相邻正常肺组织中有80.0%正常表达.WWOX基因的表达与组织类型、细胞分化程度密切相关(P<0.05),在鳞癌和低分化癌中WWOX基因失表达或表达减少.结论 WWOX蛋白在非小细胞肺癌组织中呈低表达,该蛋白表达的缺失可能在不同类型非小细胞肺癌的形成中发挥了不同的作用.     

关于连续刚构桥梁的施工管理控制要点分析

在桥梁施工中,连续刚结构桥梁是非常重要的组成部分,具有大跨度的特征,在连续钢构桥梁的实际施工过程中,通常需要采用悬臂施工的方式对结构体系进行转换。因此,为了确保桥梁施工能够安全稳定的进行,就必须加强连续刚构桥梁的施工管理控制工作。主要从以下三个方面针对连续刚构桥梁的施工管理控制要点进行了探讨分析,可为同行业者提供参考。     

自行车流视频识别判断方法研究

考虑算法的实时性,交通流个体识别往往采用轮廓特征来描述。由于自行车与行人的很多轮廓特征值相近,在复杂城市交通环境中,从慢行交通流中准确地识别出自行车是目前采用视频检测交通流的难点之一。通过现场视频检测获取足够的样本外轮廓数据,分析检测目标轮廓的高、宽、高宽比、面积等典型轮廓特征,发现目标轮廓高宽比特征能较好地识别出行人、自行车等慢行交通,并给出合适的取值范围。研究表明自行车高宽比能够较好地成为视频识别的依据,为自行车视频识别提供数据。     

高速公路直线路段突起路标间隔设置方法

基于驾驶人的视觉惰性、视觉警示频率和感觉特性,分析了突起路标的视觉警示作用,确定了突起路标的闪现频率,计算与修正了突起路标的初始间隔。应用ADAMS/Car仿真软件模块,建立了道路、车辆和突起路标模型,将车型设置为大型车和小型车,大型车的车速设置为60、80、100km·h-1,小型车的车速设置为80、100、120km·h-1,大型车和小型车的方向盘转角均设置为1°、3°、5°。分别对提出的12m间隔与现行规范推荐的15m间隔各进行243次仿真,分析振动警示效果。仿真结果表明:在12m间隔下,平均碾压率为93.1%,小型车和大型车对应的平均警示率分别为41.7%和5.6%;在15m间隔下,平均碾压率为93.7%,小型车和大型车对应的平均警示率分别为33.3%和28.9%;12、15m间隔对小型车都具有较好的振动警示效果,15m间隔对大型车的振动警示效果更好。当高速公路夜间交通流较大或需要加大交通设施的夜间安全效果时,可选12m间隔提供良好的视觉连续性和视觉警示效果;考虑施工维护的方便性和经济性或者大型车比例较大时,可选择15m间隔。     

MIF在不同分子分型乳腺癌中的表达和意义

目的研究巨噬细胞移动抑制因子(MIF)在不同分子分型乳腺癌中的表达和临床意义,探索不同分型乳腺癌的分子生物学特征。方法应用免疫组化SP法将100例乳腺癌标本分为Luminal型、HER2(+)型、BLs型和NBLs型,检测MIF表达差异。比较不同年龄、月经状况、肿瘤大小、腋窝淋巴结转移状态、肿瘤组织学类型、组织学分级和术后临床分期患者中MIF阳性表达率;比较MIF阳性患者和阴性患者的微血管密度(MVD)数值差别及5年总生存率。结果不同分子分型和不同淋巴结转移状态的乳腺癌患者中,MIF阳性表达率有统计学差异(P<0.05)。MIF表达与HER2(+)型乳腺癌及腋窝淋巴结转移皆正相关。MIF阳性者的MVD值明显高于阴性者(P<0.05)。Kaplan-Meier法示MIF阴性者的5年生存率明显高于MIF阳性者(Log-rank=19.516,P=0.000)。结论 MIF阳性的乳腺癌患者多为HER2(+)型,易发生腋窝淋巴结转移,肿瘤新生血管明显,预后不良。     

实现滨江临海城市大交通的关键技术研究

文章提出了滨江沿海城市大交通的概念,分析了智能交通的实现路径,针对关键技术和经济效益进行了分析,并进行了实例研究,具有一定的应用价值。