THE CYTOTOXIC EFFECTS OF CRUDE BILE ON HUMAN PANCREATIC CANCER CELL LINES

Thebileacidswereconfirmedasnonspecificcytotoxicsubstanceswhichplayveryimportantro1einpathophysiologyofextrahepaticcholesta-sis[la.Invitrostudieshadprovedthatthebileacidscouldcausechronicandacuteinjuryofpancreaticductalepitheliumactingasaninitiatorofpancre-atitist2i.Thepancreaticcancerisamajorworld-widepublichealthproblernandremainsasignifi-cantclinica1challenge.Atthetimeofdiagnosis,about7o%ofpancreaticcancerpatientsmanifestobstructivejaundicewhichcanresultinprogressiveliverdysfunctionandculmin…     

Factors associated with bicycle ownership and use: a study of six small U.S. cities

As a means of transportation and as a form of physical activity, bicycling generates benefits to the bicyclist as well as to the community as a whole. Bicycling now accounts for less than 1 percent of all trips for all purposes in the U.S., but evidence from other western countries suggests that under the right conditions, bicycling levels can be significantly higher. Indeed, the experiences of some U.S. cities suggest that it is possible to create conditions conducive to higher levels of bicycling even in the U.S. However, the extent to which bicycle investments have contributed to bicycling levels in these communities has not been rigorously assessed. The purpose of this study is to provide a better understanding of the determinants of bicycle ownership and use as a basis for identifying ways to promote bicycling. A cross-sectional study of six cities was designed to test the importance of bicycle infrastructure and other physical environment factors relative to individual factors and social environment factors, using a nested logit model to examine ownership and use decisions jointly. The results show strong effects of individual attitudes and physical and social environment factors on bicycle ownership and use.     

Virtually being there: Human aspects of shore-based ship assistance

Shore-based ship assistance is a topic that increasingly is attracting attention from the maritime community. Subjects such as shore-based pilotage and VTS are often discussed and there is technological and political pressure towards more extensive forms of such assistance. Perhaps less often mentioned, but not less important, is the human side of these subjects. The present paper examines two of the central concerns for the people who actually work within today’s VTS centers, namely communication and trust. The study consisted of a literature review, study visits, observations and interviews. Communication and trust are found to be closely related, and one main finding is that adapting one’s means of communication to the context can be a very powerful (and necessary) tool for the creation of trust. Another important result is that the ability of the shore-based operator to see the situation from the viewpoint of the crew is crucial for the creation and maintenance of trust.     

不同驱动方式下表贴式交流永磁电机转子涡流损耗研究

针对转子涡流损耗在某些表贴式交流永磁电机中引起很高的温升问题,本文采用有限元软件仿真分析了三相永磁电机在方波和正弦波驱动方式下的转子涡流损耗的变化规律。分析表明：同转速、同转矩条件下,方波驱动的转子涡流损耗要大于正弦波驱动的,且二者之差随转速和负载的增大而增大。稳定时,方波驱动产生的转子涡流损耗每个电周期有6次波动,这主要是由绕组谐波电流引起的。     

AM12软件电气建模优化方法探讨

本文介绍了我院应用AM12（AVEVA Marine 12）软件进行海洋工程设计的背景及使用情况,分析了现有的电气建模方式与方法,并着重讨论了自主完成的电气建模优化方法与AM12软件电气设计相关的二次开发情况。     

汽车动力总成三点式悬置系统的设计方法探讨

首先分析汽车动力总成一悬置系统的振动激励、质量矩阵、刚度矩阵各元素的特点及其相互关系,阐释了系统弹性解耦设计的理论基础和重要性。然后根据动力总成一悬置系统刚度矩阵各元素的解析表达式,应用V形悬置组的弹性解耦原理,论述了目前普遍应用的三点式悬置系统在弹性解耦设计方面的问题,提出了悬置布置设计匹配的有效方法。     

沥青混合料的集料比表面积确定方法的研究

通过对沥青混合料集料比表面积确定的传统方法进行研究,并对矿粉和集料的表面积进行了实测,以及对沥青混合料的集料表面积系数进行推导,认为现有的确定沥青混合料的集料比表面积的方法值得商榷.通过对这两种方法进行分析,并结合沥青混合料的集料比表面积的实测结果,提出了不同于常用方法的沥青混合料的集料比表面积的确定方法,并确定了集料...     

核受体免疫组织化学染色时抗原修复方法的选择

目的 探讨不同抗原修复法对DA.1U大鼠肝组织内核受体检测结果的影响.方法 应用微波修复法、高压修复法、酶修复法和高压加酶修复法对DA.1U大鼠肝组织切片进行修复,然后进行免疫组化染色.结果 DA.1U大鼠肝组织内核受体LXR-α、LXR-β、PPAR-γ和FXR经高压抗原修复后,染色阳性强度较其他修复方法明显增强,而且定位较佳.结论 在核受体免疫组化染色中高压抗原修复法染色效果优于其他抗原修复法.     

Approximations to the magic formula

Pacejka’s tire model is widely used and well-known by the automotive engineering community. The magic formula describes the brake force, side force and self-aligning torque in terms of the longitudinal slip and slip angle, plus several corrections. This paper uses approximation theory to obtain different types of approximations to the magic formula: rational functions (RA) resulting from the Remez algorithm, expansions in a series of Chebyshev polynomials (ACh), a series of Chebyshev rational polynomials (ARChPs), a series of rational orthogonal functions (ORF) and a series of ARChPs that result from grade-1 ORFs. The last expansion shows the fastest convergence and most effective computation. Jacobi rational polynomials can also be obtained to complement this expansion and facilitate fine-tuning in specific areas of the error curve. This work is complemented by obtaining the original rational approximations to the inverse tangent function, which take advantage of the curve symmetry to reduce the computation load and provide models that include the influence of the vertical load. The convergence properties of the development in series and the error values resulting from numeric examples for the three types of stress are shown. The proposed final ARChP expressions show very low error (1%) compared to the original magic formula. They can be computed 20 times faster; they can be evaluated, derived and integrated analytically easily; and their coefficients can be obtained from tests using common least-squares algorithms.     

Robust lane markings detection and road geometry computation

Detection of lane markings based on a camera sensor can be a low-cost solution to lane departure and curve-over-speed warnings. A number of methods and implementations have been reported in the literature. However, reliable detection is still an issue because of cast shadows, worn and occluded markings, variable ambient lighting conditions, for example. We focus on increasing detection reliability in two ways. First, we employed an image feature other than the commonly used edges: ridges, which we claim addresses this problem better. Second, we adapted RANSAC, a generic robust estimation method, to fit a parametric model of a pair of lane lines to the image features, based on both ridgeness and ridge orientation. In addition, the model was fitted for the left and right lane lines simultaneously to enforce a consistent result. Four measures of interest for driver assistance applications were directly computed from the fitted parametric model at each frame: lane width, lane curvature, and vehicle yaw angle and lateral offset with regard the lane medial axis. We qualitatively assessed our method in video sequences captured on several road types and under very different lighting conditions. We also quantitatively assessed it on synthetic but realistic video sequences for which road geometry and vehicle trajectory ground truth are known.