Comparative study on ghrelin level change and its related factors in hypertensive elders with psychological distress

Objective To investigate the change of plasma ghrelin level and explore the related factors of ghrelin alteration in elderly hypertensive patients with psychological distress. Methods A total of 300 elders, who were screened with Hamilton Anxiety Scale (HAMA), Hamilton Rating Scale for Depression (HAMD), and the Symptom Checklist-90 (SCL-90) for psychological stress and somato-psychological manifestations respectively, were divided into hypertension group (n=148) and non-hypertension group (n=152). Their blood samples were collected to measure the plasma level of ghrelin and total cortisol on the same day. Results The incidences of anxiety and depression were 27.7% and 11.7%, respectively, in all the enrolled elders. However, the rates of psychological distress, particularly anxiety, were significantly higher in the hypertensive elders than in the non-hypertensive ones (43.2% vs. 12.5%). Anxiety was positively related to the cortisol level but negatively related to the plasma ghrelin level, and the latter two were negatively correlated with each other. Conclusion Chronic increase of plasma cortisol induced by long-term anxiety can lead to the reduction of ghrelin level, which then adversely affects blood pressure in elders with psychological distress. Therefore, ghrelin might be a selective antihypertensive medicine for hypertensive elders with anxiety.     

Inhibitory action of docetaxel on the proliferation of HeLa and SiHa cells

Objective To study the inhibitory action of docetaxel (DOC) on the proliferation of HeLa and SiHa cells. Methods Cell morphological changes were observed with inverted phase contrast microscope. MTT was adopted to test and calculate the cell inhibition ratio. Flow cytometry was used to detect cell cycle. Results DOC had an obvious concentration-dependent inhibitory effect on the proliferation of both HeLa and SiHa cells. The inhibition ratio of DOC on SiHa was significantly higher than that on HeLa (P<0.05). DOC blocked HeLa at G2/M phase. Under the effect of DOC, the cell cycle of SiHa was not changed much. Conclusion DOC has an obvious inhibitory action on both HeLa and SiHa cells, which shows a promising prospect of DOC in clinical treatment of cervical cancer.     

F3000车型总装配线工艺改造

通过对总装配线现状和F3000车型的主要结构特征进行分析,从工艺流程、设备、工装等方面对总装配线进行改造,实现F3000车型批量装配的目标。     

重庆滨江路加筋护岸工程加固方案研究

在对重庆滨江路加筋护岸整治工程安全性分析基础上。运用二维有限元数值计算法和强度折减理论对两种加固方案进行了安全性分析。经综合比较,推荐采用格宾块石箱体结构方案进行加固。     

汽车动力总成隔振难点与被动悬置改进技术

简述了发动机导致车内噪声的两种方式,即振动传递方式和辐射方式.基于发动机的激励特点和传递方式论述了发动机对整车振动噪声的影响规律及控制措施.基于动力总成隔振悬置需要满足的诸多冲突因素和约束条件,论述了汽车动力总成隔振设计难点,并阐述了被动式悬置改进技术.     

电流变阻尼半主动控制悬架系统的设计

汽车悬架减振器对于保证车辆的乘坐舒适性和安全稳定性都具有重要作用,但目前普遍应用的被动式减振器因其力学性能不能调节,存在只能在两种性能之间折衷的先天不足,而智能半主动悬架系统方案基于“大系统多级递阶——子系统神经网络自适应”控制算法。并利用MATLAB＋Simulink对新型智能半主动悬架系统进行了仿真试验．试验结果表明系统在实现了提高车辆乘坐舒适性能的同时兼顾了安全稳定性的目的。同时由于采用电流变液减振器,使系统本身具有实时采集、响应迅速、智能化、减振降噪效果好等特点。     

重大交通突发事件中的态势评估研究

态势评估是交通应急管理的基础.针对重大交通突发事件中的态势评估,提出了分析预测流程,并对态势要素及各阶段功能进行阐述.结合国内外已有的态势评估研究成果,举例说明人工智能方法在突发事件态势评估领域的应用.     

千岛湖1号桥桥面铺装层受力敏感性分析

明确铺装结构受力特性是桥面铺装材料设计的前提条件。结合千岛湖1号桥实体工程,为了给后续铺装用沥青混凝土材料选择和结构设计提供技术支持,针对大跨径水泥混凝土桥面受力特点,运用三维有限元分析软件建立合理的力学模型,对铺装层数、铺装层厚度、铺装层模量、外界温度和荷载大小等影响因素做出敏感性分析。研究表明：上述因素对铺装层受力都有一定的影响,其中桥面摩擦系数和胎压的影响最为敏感,建议在桥面铺装设计时,在满足桥面抗滑性能的基础上,尽量减小摩擦系数,并严格控制超载车辆。     

Provably Secure Short Proxy Signature Scheme from Bilinear Maps

An enhanced formal model of security for proxy signature schemes is presented and a provably secure short proxy signature scheme is proposed from bilinear maps. The proposed proxy signature scheme is based on two short secure signature schemes. One is used for delegating the signing rights and computing the standard signature; the other is used for computing proxy signature. Finally, a security proof of the proposed proxy signature scheme is showed by reducing tightly the security of the proposed proxy signature scheme to the security of the two basic signature schemes. The proposed proxy signature scheme has the shortest ordinary signatures and proxy signatures. Moreover, the proxy signature generation needs no pairing operation and verification needs just two pairing operation.     

一种改进的形态学边缘检测方法

对经典形态学进行了3点改进,提出一种多尺度多级级联自适应加权图像边缘检测算法.经实验结果表明,与其他方法相比,该算法抗噪性能更优,得到的边缘图像具有良好的边缘细节特性,算法比较简单,具有一定的实用性和可行性.