Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10

Objective To map a mouse deafness gene.identify the underlying mutation and develop a mouse model for human deafncss.Methods Genetic lindage cross and genome scan wer used to map a novel mutation named hypoplasia of the membranous labyrinth (hml),which causes hearing loss in mutant mice.Results ① hml was mapped on mouse Chr 10 (～43 cM from the centromere) suggests that the homologous human gene is on 12q22--q24, which was defined on the basis of known mouse-human homologies (OMIM,2004). ② This study has generated 25 polymorphic microsateUite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500 kb area.     

Two-Dimensional Motion of Vehicles Damaged due to Collision

This paper deals with two-dimensional motion analysis of vehicles damaged due to collision. Various parts of vehicles are damaged due to collision in general. The effects of the damage in vehicle body and wheels on the vehicle motions are investigated. The center of gravity of the vehicle and the polar moment of inertia are changed by the deformation of vehicle body. Furthermore, the geometrical relations of wheels like wheelbase, treads and steering angles may be changed by damage of the wheels. Thus the vehicle loses symmetry with respect to the vehicle axis. The four-wheel vehicle model is extended to take into account the vehicle damage due to collision. The motions of damaged vehicles are compared with those of undamaged vehicles. It is found that vehicle damages have a significant influence on vehicle motion after impact.     

Multi-objective optimization of quarter-car models with a passive or semi-active suspension system

A systematic methodology is applied in an effort to select optimum values for the suspension damping and stiffness parameters of two degrees of freedom quarter-car models, subjected to road excitation. First, models involving passive suspension dampers with constant or dual rate characteristics are considered. In addition, models with semi-active suspensions are also examined. Moreover, special emphasis is put in modeling possible temporary separations of the wheel from the ground. For all these models, appropriate methodologies are employed for capturing the motions of the vehicle resulting from passing with a constant horizontal speed over roads involving an isolated or a distributed geometric irregularity. The optimization process is based on three suitable performance criteria, related to ride comfort, suspension travel and road holding of the vehicle and yielding the most important suspension stiffness and damping parameters. As these criteria are conflicting, a suitable multi-objective optimization methodology is set up and applied. As a result, a series of diagrams with typical numerical results are presented and compared in both the corresponding objective spaces (in the form of classical Pareto fronts) and parameter spaces.     

Generation of cyclonic eddies in the Eastern Gotland Basin of the Baltic Sea following dense water inflows: numerical experiments

A sigma (σ)-coordinate ocean model by Blumberg and Mellor (POM) is applied to study the formation processes of mesoscale cyclones observed in the Eastern Gotland Basin following the dense water inflows. The initial conditions simulate a situation when the Arkona and Bornholm basins and partially the Slupsk Furrow are already filled with the inflow water of the North Sea origin, while the Eastern Gotland and Gdansk basins still contain the old water of pre-inflow stratification. Model runs with constant and time-dependent winds, changing the buoyancy forcing, grid geometry and bottom topography display the following. Entering the Eastern Gotland Basin from the Slupsk Furrow, the bottom intrusion of saline inflow water splits in two: one goes northeast towards the Gotland Deep, and second moves southeast towards the Gulf of Gdansk. An intensive mesoscale cyclonic eddy carrying the inflow water is generated just east of the Slupsk Furrow with the inflow pulse. A number of smaller cyclones with boluses of the inflow water are formed in the permanent halocline along the saline intrusion pathway to the Gotland Deep. Following Spall and Price [J. Phys. Oceanogr. 28 (1998) 1598], the cyclones are suggested to form by the adjustment of the high potential vorticity inflow water column to a low potential vorticity environment.     

Using a random displacement model to simulate turbulent particle motion in a baroclinic frontal zone: A new implementation scheme and model performance tests

Numerical artifacts can limit accurate simulation of turbulent particle motion when Lagrangian particle-tracking models are implemented in hydrodynamic models with stratified conditions like fronts. Yet, modeling of individual particle motion in frontal regions is critical for understanding sediment dynamics as well as the transport and retention of planktonic organisms. The objective of this research was to develop a numerical technique to accurately simulate turbulent particle motions in a particle-tracking model embedded within a hydrodynamic model of a frontal zone. A new interpolation scheme, the ‘water column profile’ scheme, was developed and used to implement a random displacement model for turbulent particle motions. A new interpolation scheme was necessary because linear interpolation schemes caused artificial aggregation of particles where abrupt changes in vertical diffusivity occurred. The new ‘water column profile’ scheme was used to fit a continuous function (a tension spline) to a smoothed profile of vertical diffusivities at the x–y particle location. The new implementation scheme was checked for artifacts and compared with a standard random walk model using (1) Well Mixed Condition tests, and (2) dye-release experiments. The Well Mixed Condition tests confirmed that the use of the ‘water column profile’ interpolation scheme for implementing the random displacement model significantly reduced numerical artifacts. In dye-release experiments, high concentrations of Eulerian tracer and Lagrangian particles were released at the same location up-estuary of the salt front and tracked for 4 days. After small differences in initial dispersal rates, tracer and particle distributions remained highly correlated (r = 0.84 to 0.99) when a random displacement model was implemented in the particle-tracking model. In contrast, correlation coefficients were substantially lower (r = 0.07 to 0.58) when a random walk model was implemented. In general, model performance tests indicated that the ‘water column interpolation’ scheme was an effective technique for implementing a random displacement model within a hydrodynamic model, and both could be used to accurately simulate diffusion in a highly baroclinic frontal region. The new implementation scheme has the potential to be a useful tool for investigating the influence of hydrodynamic variability on the transport of sediment particles and planktonic organisms in frontal zones.     

Exact and simplified estimations for elastic buckling pressures of structural pipe-in-pipe cross sections under external hydrostatic pressure

Structural pipe-in-pipe cross sections have significant potential for application in offshore oil and gas production systems because they combine thermal insulation performance with structural strength and self weight in an integrated way. Such cross sections comprise inner and outer thin-walled pipes with the annulus between them fully filled by a selectable filler material to impart an appropriate combination of properties. Structural pipe-in-pipe cross sections can exhibit several different collapse mechanisms, and the basis of the preferential occurrence of one over the others is of interest. This article presents an exact analysis for predicting the elastic buckling behaviours of a structural pipe-in-pipe cross section when subjected to external hydrostatic pressure. Simplified approximations are also investigated for elastic buckling pressure and mode when the outer pipe and its contact with the filler material is considered as a pipe on an elastic foundation. Results are presented to show the variation of elastic buckling pressure with the relative elastic modulus of the filler and pipe materials, the filler thickness, and the thicknesses of the inner and outer pipes. Case studies based on realistic application scenarios are used to show that the simplified approximations are sufficiently accurate for practical structural design purposes.     

Transport of radionuclides by sea-ice and dense-water formed in western Kara Sea flaw leads

A transport assessment of particle-bound and dissolved artificial radionuclides (¹³⁷Cs and ^239,240Pu) by sea-ice and dense-water formed in western Kara Sea flaw leads close to the Novaya Zemlya dumping sites is presented in this study. We both performed a “best estimate” based on available data, and a “maximum assessment” relying on simulated constant releases of 1 TBq ¹³⁷Cs and ^239,240Pu from individual dumping bays. The estimates are based on a combination of (i) the content of particulate matter in sea-ice; (ii) analytical data and numerical simulations of radionuclide concentrations in shelf surface deposits, suspended particulate matter (SPM), and the dissolved phase; and (iii) estimates of lead-ice and dense-water formation rates as well as modeling results of local ice drift pathways. In the “best estimate” case, 2.90 GBq ¹³⁷Cs and 0.51 GBq ^239,240Pu attached to sea-ice sediments can be exported from the lead areas toward the central Arctic basin. The radionuclide burden of the annually formed dense lead water in the “best estimate” amounts to 4.68 TBq ¹³⁷Cs and 0.014 TBq ^239,240Pu. In the “maximum assessment”, potential export-rates of ice-particle bound ¹³⁷Cs and ^239,240Pu toward the central Arctic would amount to 0.64 and 0.16 TBq, respectively. As much as ≈900 TBq ¹³⁷Cs and ≈6.75 TBq ^239,240Pu could be annually taken up by 34.75 dense-water rejected in the lead area. Assuming the (unlikely) instantaneous release of the total ¹³⁷Cs and ^239,240Pu inventories (≈1 PBq and 10 TBq, respectively) from the Novaya Zemlya dumping sites into the dissolved phase, the dense lead water locally formed during one winter season could take up ≈90% of the Cs and ≈68% of the Pu released.     

Unsteady finite-depth effects during resistance tests on a ship model in a towing tank

This paper covers an extension of the study of Doctors et al. (J Ship Res 52(4):263–273, 2008) on oscillations in wave resistance during the constant-velocity phase of a towing-tank resistance test on a ship model to the case of relatively shallow water. We demonstrate here that the unsteady effects are very prominent and that it is essentially impossible to achieve a steady-state resistance curve in a towing tank of typical proportions for a water-depth-to-model-length ratio of 0.25. This statement is particularly true in the speed region near a depth Froude number of unity. However, on the positive side, we show here that an application of unsteady linearized wave-resistance theory provides an excellent prediction of the measured total resistance, when one accounts for the form factor in the usual manner. Finally, a simple application of the results to the planning and analysis of towing-tank tests is presented.