探地雷达在桥梁预应力管道定位检测中的应用

对预应力管道进行定位检测,是目前桥梁无损检测技术的一个重要问题,在阐述探地雷达无损检测技术原理和方法的基础上,通过室内模型试验,并结合工程实例说明了高精度探地雷达在桥梁预应力管道定位检测中的应用,及其无损、简易、效率高、精度高、抗干扰能力强的优点,为准确评价桥梁结构耐久性和安全使用功能提供科学依据。     

Hybrid process of fabricating high-quality micro wine-glass fused silica resonators

A new hybrid method, which combines improved glass-blown technology with wet etching, is reported to fabricate micro wine-glass resonators with high-quality fused silica. The optimum placement is compared to achieve the resonators with good shell shape. The typical shell diameter is about 4mm and its thickness covers from dozens to hundreds of micrometers. The etching rates in corrosion solutions with different ratios and at different thicknesses of hemispherical shells are studied. We also conclude how to precisely control the thickness. The corrosion solutions with different ratios of HF solution to NH₄F solution make the spherical shells rougher in different degrees. The best roughness is 0.581 nm in the 1: 8 ratio corrosion solution while the original roughness is 0.537 nm. This fact shows that the resonator remains atomically smooth surface. Based on the glassblowing spherical fused silica structure, the thickness of the resonator is effectively controlled by buffered oxide etch (BOE) technology according to the measured etching rate. The measured resonant frequency of the hemispherical shell at ambient pressure and room temperature is 1.75 kHz of rocking mode which is close to the simulated frequency. Using such a low-cost hybrid approach, we can fabricate high-quality microscale resonators in batch.     

Impacts of urban built environment on empty taxi trips using limited geolocation data

This study identifies the determinants of the empty taxi trip duration (ETTD) by combining three high-resolution databases—geolocation data in New York City, geodatabase of urban planning data, and transportation facilities data. Considering the nature of duration data, hazard-based duration model is proposed to explore the relationships between causal factors and ETTD, coupling with three variations of baseline hazard distribution, i.e., Weibull distribution with heterogeneity, Weibull distribution, and log-logistic. Furthermore, the likelihood ratio test is presented to implement comparisons of three baseline hazard distributions, as well as spatial and temporal transferability of causal factors. The results show significant complementary effects by subway system and competitive effects by city bus and bicycling system, as well as significant impacts of trip length, airport trip, average annual income, and employment rate. Urban built environment, for instance, density of road, public facilities, and recreational sites and ratio of green space, has various impacts on ETTD. The elasticity estimations confirm significant spatial and temporal heterogeneity in impacts on ETTD. In addition, the analysis on elasticity also reveals the considerable impacts of severe traffic congestion on ETTD within Manhattan. The modeling can assist stakeholders in understanding empty taxi movements and measuring taxi system efficiency in urban areas.     

Estimation of delay variability at signalized intersections for urban arterial performance evaluation

Urban arterial performance evaluation has been broadly studied, with the major focus on average travel time estimation. However, in view of the stochastic nature of interrupted flow, the ability to capture the characteristics of travel time variability has become a critical step in determining arterial level of service (LOS). This article first presents a stochastic approach that integrates classic cumulative curves and probability theories in order to investigate delay variability at signalized intersections, as a dominant part of the link travel time variability. This serves as a basis for arterial travel time estimation, which can be obtained through a convolution of individual link travel time distributions. The proposed approach is then applied in the estimation of travel time along one arterial in Shanghai, China, with abundant automatic vehicle identification (AVI) data sources. The travel time variability is evaluated thoroughly at 30-min intervals, with promising results achieved in comparison to the field measurements. In addition, the estimated travel time distributions are utilized to illustrate the probability of multiple LOS ranges, namely, reliability LOS. The results provide insights into how we might achieve a more reliable and informative understanding of arterial performance.     

Subjective-utility travel time budget modeling in the stochastic traffic network assignment

ABSTRACT

In this article, we propose a new model called subjective-utility travel time budget (SU-TTB) model to capture travelers' risk-averse route choices. In the travel time budget (TTB) and mean-excess travel time (METT) model, a predefined confidence level is needed to capture the risk-aversion in route choice. Due to the day-to-day route travel time variations, the exact confidence level is hard to be predicted. With the SU-TTB model, we assume travelers' confidence level belongs to an interval that they may comply with in the route choice. The two main components of SU-TTB are the utility function and the TTB model. We can show that the SU-TTB can be reduced to the TTB and METT model with proper utility function for the confidence levels. We can also prove its equivalence with our recently proposed nonlinear-expectation route travel time (NERTT) model in some cases and give some new interpretation on the NERTT with this equivalence. Finally, we formulate the SU-TTB model as a variational inequality (VI) problem to model the risk-averse user equilibrium (RAUE), termed as generalized RAUE (GRAUE). The GRAUE is solved via a heuristic gradient projection algorithm, and the model and solution algorithm are demonstrated with the Braess's traffic network and the Nguyen and Dupuis's traffic network.     

社会转型期大学生思想道德教育对策思考

随着网络化、经济全球化的进程,中国社会正处在深刻变革和快速转型期,人们的价值观念、思维方式和行为方式发生剧烈变化,传统的道德规范受到了强烈冲击。正处在人生观、价值观、道德观的形成时期的大学生,面临极大的道德冲突与思想困惑。文章在分析大学生的思想道德现状及其成因的基础上,就社会转型期如何加强大学生思想道德建设进行探讨。     

TNFα、Leptin-Rb、NF-κB和PPAR-γ在酒精性肝病大鼠肝细胞中的表达

目的 探讨TNFα、NF-κB、Leptin-Rb和PPAR-γ等在大鼠酒精性肝病中与肝组织炎症、坏死和纤维化的关系.方法 胃造瘘法建立长期大鼠酒精性肝病模型,分别在第4、8、12、24和52周用免疫组化、原位杂交和RT-PCR技术检测不同阶段大鼠肝组织中TNFα、NF-κB、PPAR-γ和Leptin-Rb等的表达.结果 TNFα、NF-κB和Leptin-Rb水平在模型组大鼠肝细胞中,第8周表达逐渐增强,第24周起高水平表达一直持续至52周(P<0.01).PPAR-γ在对照组和第4、8周模型组肝细胞中表达最强,第12周表达开始减弱.TNFα和NF-κB在肝细胞中的表达呈明显正相关关系,与PPAR-γ则呈负相关关系(P<0.01).结论 TNFα和NF-κB与肝细胞病变程度有很好的一致性关系,Leptin-Rb在肝细胞的表达与肝纤维化发展相一致,PPAR-γ则刚好相反.     

羟基喜树碱对人胆管癌QBC939裸鼠移植瘤PS2、COX-2的影响

目的探讨羟基喜树碱对人胆管癌QBC939裸鼠移植瘤的乳癌相关肽(PS2)、环氧合酶-2(COX-2)的影响,分析PS2、COX-2与肿瘤发生、发展的关系。方法建立人胆管癌QBC939细胞株裸鼠皮下移植瘤模型,将30只裸鼠随机分成对照组、羟基喜树碱低剂量组和羟基喜树碱高剂量组,观察移植瘤体生长情况,RT-PCR法检测瘤体内PS2、COX-2 mRNA表达。结果与对照组比,羟基喜树碱低、高剂量组都可使移植瘤体的PS2 mRNA表达增高;COX-2 mRNA表达降低,且瘤体生长减慢,与对照组比较差异有统计学意义(P<0.01)。结论羟基喜树碱可降低移植瘤COX-2 mRNA表达,增高移植瘤体的PS2 mRNA表达,并使人胆管癌裸鼠移植瘤生长减慢。     

The changes of neuronal activity of the zone incerta in a rodent model of Parkinson＇s disease

Objective To study the changes in neuronal activity of the zone incerta (ZI) following the unilateral lesion of the nigrostriatal pathway. Methods Eiectrophysiological recordings of ZI neurons were made in normal rats and in two groups of rats at different time intervals after injection of 6-hydrodopamine (6-OHDA) into the pars compacta of snbstantia nigra by extracellular recording in vivo. Results The results showed a significant increase in the mean firing rate of ZI during the second and fourth weeks after 6-OHDA lesion [-n=32, (3.6±2. 2)Hz, P<0.001; n=35, (9.3±6.6)Hz, P<0. 001, respectively] compared to that of normal rats [n=39, (9.2±5.2)Hz]. However, no significant change was observed between two groups of 6-OHDA-lesioned rats. With regard to firing pattern, 7.7%(3/39) of ZI neurons discharged regularly, 82.1% (32/39) irregularly and 10. 3% (4/39) in bursts in normal rats. During the second week after 6-OHDA lesion, the regular, irregular and bursting firing neurons recorded in the ZI were 9.4% (3/32), 59. 4% (19/32) and 31.3% (10/32), and during fourth week, the regular, irregular and bursting firing neurons were 14.3% (5/35), 57.1% (20/35) and 28. 6% (10/35), respectively. The firing pattern of the neurons in the three different groups did not change significantly. Conclusion These results suggest that the firing rate of ZI neurons in 6-OHDA-lesioned rats is increased significantly, which may contribute to the pathophysiology of Parkinson's disease.     

健胃愈疡颗粒对慢性胃炎伴幽门螺杆菌感染胃黏膜PAF、PS2的表达及对上皮细胞凋亡的影响

目的观察健胃愈疡颗粒(JWYY)对幽门螺杆菌相关性胃炎胃黏膜乳癌相关肽(PS2)和血小板活化因子(plate-let activating factor,PAF)表达的变化,并分析其可能的作用机制。方法80例幽门螺杆菌感染慢性胃炎患者随机分为2组,治疗组42例给予健胃愈疡颗粒治疗,对照组38例给予西药三联药物治疗。应用胃镜下活检胃黏膜组织快速尿素酶和Warthin-Starry染色法检测幽门螺杆菌,应用Western blot检测PS2、PAF表达变化。应用末端转移酶介导的dUTP切口末段标记法(TUNEL)检测细胞凋亡。第4周复查胃镜。结果治疗组凋亡指数明显比对照组减少(P<0.05),治疗组总有效率高于对照组(P<0.05)。Western blot检测显示:JWYY颗粒可上调PS2并下调PAF的表达,而对照组对胃黏膜PS2和PAF的表达影响不大。结论健胃愈疡颗粒治疗幽门螺杆菌(Hp)相关性胃炎可能与杀灭Hp、上调PS2和下调PAF的表达来抑制细胞凋亡有关。