Facility Layout Based on Sequence Analysis： Design of Flowshops

A computer-aided method to design a hybrid layout—tree-shape planar flowlines is presented. In newtype flowshop layout, the common machines shared by several flowlines could be located together in functional sections. The approach combines traditional cell formation techniques with sequence alignment algorithms. Firstly, a sequence analysis based cell formation procedure is adopted; then the operation sequences for parts are aligned to maximize machines adjacency in hyperedge representations; finally a tree-shape planar flowline will be obtained for each part family. With the help of a sample of operation sequences obtained from industry, this algorithm is illustrated.     

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研究了求解城市交通连续网络设计问题的模拟退火算法参数选择原则。采用双层规划模型来描述固定需求下的城市交通连续网络设计问题,其中上层问题的目标函数为整个网络的总阻抗和总投资额之和,下层问题则是用户平衡配流模型。利用模拟退火算法求解上层模型,下层模型则采用基于路径的GP算法进行求解。本文首次采用了灵敏度分析方法分析参数选择对模拟退火算法求解连续网络设计问题影响,比较了各个参数对算法结果及时间的影响,确定了参数的选择原则。根据上述分析方法得到的参数选择原则来设定参数的取值,能够提高算法的执行效率和收敛精度。     

急性髓细胞白血病FLT3-ITD基因突变的检测及其临床意义

目的 探讨急性髓细胞白血病(acute myeloid leukemia,AML)患者人Fms样酪氨酸激酶3内部串联重复(Fms-like tyrosine kinase3-intenal tandem duplication,FLT3-ITD)基因突变及其临床意义.方法 采用聚合酶链反应-变性高效液相色谱(polymerase chain reaction-denaturing high performance liquid chromatography,PCR-DHPLC)方法检测60例初治AML患者和10例对照组骨髓FLT3-ITD基因突变.结果 60例AML患者FLT3-ITD突变阳性率21.67%(13/60),10例对照组均未检测到该突变;FAB各亚型FLT3-ITD突变率不同,有M3型突变率较高的趋势;FLT3-ITD阳性组外周血白细胞数、骨髓白血病细胞比例高于FLT3-ITD阴性组(P<0.01);FLT3-ITD阳性组完全缓解(CR)率低于FLT3-ITD阴性组(P<0.05).结论 FLT3-ITD基因突变多见于M3患者,FLT3-ITD阳性者具有外周血白细胞数、骨髓白血病细胞比例高、CR率低的特点.FLT3-ITD基因突变可作为预测AML预后的一个指标.     

Protective effect of glutamine pretreatment on ischemia-reperfusion injury of spinal cord in rabbits

Objective To investigate the effect of glutamine (Gln) on the content of reduced glutathione hormone (GSH) and aminoglutaminic acid (Glu) of spinal cord following ischemia-reperfusion injury. Methods Totally 40 healthy adult male rabbits were randomly divided into five groups: sham-operation group (S group), ischemia-reperfusion injury group (I/R group), low-dose glutamine group (L Gln group), median-dose glutamine group (M Gln group) and high-dose glutamine group (H Gln group). After glutamine preconditioning, the model of spinal cord ischemia-reporfasion injury was established according to Zivin's method. The general status of animals was observed and the changes of Jacobs scoring were recorded in each group. Malondialdehydes (MDA), GSH, Glu and superoxide dismutase (SOD) activity in lumbar spinal cord tissues were determined using chemical colorimetry. The neuron number and deviation rate in spinal cord anterior horn were observed histopathologically. Results There was no significant difference between L Gin group and I/R group in behavior scoring, SOD activity, content of MDA and Glu, neuron number and deviation rate of spinal cord (P>0.05); however, there was a significant difference in GSH content of spinal cord (P<0.05). M Gln group and I/R group differed significantly (P<0.05) in behavior scoring, SOD activity, content of MDA, Glu, GSH, neuron number and deviation rate of spinal cord. Between H Gln group and M Gln group, there was no significant difference in behavior scoring, content of MDA and Glu, SOD activity, neuron number and aberration rate in spinal cord (P>0.05), whereas there was a significant difference in SOD activity and Giu content (P<0.05). Conclusion Pretreatment with medium-dose glutamine has a protective effect on spinal cord ischemia-reporfasion injury in rabbits, which may be related to the maintenance of GSH content, increase of SOD activity and reduction of MDA.     

高速公路沥青混凝土路面早期坑槽性破坏的预防

对高速公路沥青混凝土路面早期坑槽性破坏的外观现象、诱发原因做了较详细的论述,并提出了预防措施.     

上海某铝合金人行天桥荷载试验分析

该文对上海某铝合金人行天桥的静动载试验进行了介绍和结果分析,所得结论和数据可为今后铝合金桥梁的设计、研究提供参考。     

如何才能彻底消除路面反射裂缝

该文针对"白改黑"和"白加黑"工程中出现的反射裂缝,提出用共振破碎技术彻底解决这一长期困扰工程界的技术问题。并且对以前和现在常用的处理方法进行比较,阐明为什么要将板块破碎,破碎的机理是什么,用工程实例说明破碎法处理裂缝的后期效果。其内容对类似工程有一定的借鉴和参考作用。     

Analysis of a regenerative braking system for Hybrid Electric Vehicles using an Electro-Mechanical Brake

The regenerative braking system of the Hybrid Electric Vehicle (HEV) is a key technology that can improve fuel efficiency by 20∼50%, depending on motor size. In the regenerative braking system, the electronically controlled brake subsystem that directs the braking forces into four wheels independently is indispensable. This technology is currently found in the Electronic Stability Program (ESP) and in Vehicle Dynamic Control (VDC). As braking technologies progress toward brake-by-wire systems, the development of Electro-Mechanical Brake (EMB) systems will be very important in the improvement of both fuel consumption and vehicle safety. This paper investigates the modeling and simulation of EMB systems for HEVs. The HEV powertrain was modeled to include the internal combustion engine, electric motor, battery and transmission. The performance simulation for the regenerative braking system of the HEV was performed using MATLAB/Simulink. The control performance of the EMB system was evaluated via the simulation of the regenerative braking of the HEV during various driving conditions.     

基于线框模型的白车身刚度定性仿真

提出一种参数化白车身线框几何模型的构建方法,基于此线框模型快速建立白车身刚度计算有限元模型,实现了概念设计阶段白车身刚度的定性评价.以某白车身为例,计算了概念设计阶段定性仿真模型与详细设计阶段定量仿真模犁的弯曲刚度和扭转刚度.计算结果表明,概念设计阶段和详细设计阶段的弯曲刚度与扭转刚度值均在相差10%左右.     

基于统计能量分析方法的轿车车内噪声仿真研究

阐述了统计能量分析方法的基本理论,在此基础上建立了轿车的统计能量分析模型,并进行了仿真计算.从噪声影响因素、板件声辐射贡献以及传递路径3个方面对仿真结果进行了分析,找出了影响汽车噪声的主要因素和声辐射贡献最大的板件,并提出相关减振降噪措施.通过试验结果和仿真结果的比较,验证了统计能量分析方法在预测车内噪声方面的正确性.