急性脑梗死患者胰岛素抵抗及其与肿瘤坏死因子-α关系的初步探讨

目的　探讨急性脑梗死患者胰岛素抵抗 (IR)与肿瘤坏死因子 α(TNF α)的关系。方法　检测了 42例急性脑梗死患者和 5 0例正常对照组的空腹血糖、血清胰岛素、C 肽、TNF α、TG及HDL含量 ,并计算胰岛素敏感指数 (ISI)。结果　急性脑梗死患者与正常对照组比较 ,ISI明显降低、血清TNF α明显升高 ,两者之间存在明显负相关关系 ;ISI与TG、HDL分别呈负相关、正相关关系。结论　急性动脉硬化性脑梗死患者存在着IR ,TNF α可能是IR形成的一个因素。抑制TNF α的表达可能会增加胰岛素敏感性 ,减少脑梗死的发生和减轻梗死范围。     

牙龈卟啉菌蛋白酶rgp Acd基因表达载体的构建

目的构建牙龈卟啉菌蛋白酶rgpA催化结构域(rgpAcd)基因的表达载体。方法利用PCR技术和基因重组技术,克隆牙龈卟啉菌蛋白酶rgpAcd,插入中介载体pMD18-T中并测序鉴定。将目的基因片断插入原核表达载体pET-15b,构建表达质粒pET-15b/rgpAcd,通过限制性酶切鉴定。结果PCR产物电泳结果显示,在大约1.5 kb处有一特异的条带,与预期的大小一致,核酸序列测定与分析的结果表明,克隆的1 476 bp基因序列与GenBank数据库中的序列呈现100%同源性,未发生任何突变;构建的表达质粒经酶切后所得片断与预期大小一致,表明牙龈卟啉菌蛋白酶rgpAcd基因的表达载体构建成功。结论成功克隆了牙龈卟啉菌rgpAcd基因并构建了表达载体,为进一步研制重组活载体疫苗奠定了基础。     

两自由度不同截面形式柱体涡激振动的CFD数值模拟

文章采用计算流体力学（CFD）方法,结合SST k-棕湍流模型,对低质量比柱体进行两自由度涡激振动数值模拟,得到了柱体升力、曳力系数的时程曲线,并观察了柱体进入锁振状态的幅值变化,研究了不同截面形式柱体在外流速处于0.1-1.0 m/s范围内的振动响应。将圆柱体在不同流速下两向振动的CFD数值模拟与实验数据进行比较,得到了较为满意的结果。通过分析不同截面柱体在不同外流速下的振动幅值发现,带有抑振装置的柱体截面形式能够有效地减小涡激振动,其中,板状截面柱体抑振效果较好。     

Simulation of hydrodynamic performance of drag and double reverse propeller podded propulsors

The unsteady performance of drag and double reverse propeller podded propulsors in open water was numerically simulated using a computational fluid dynamics (CFD) method. A moving mesh method was used to more realistically simulate propulsor working conditions, and the thrust, torque, and lateral force coefficients of both propulsors were compared and analyzed. Forces acting on different parts of the propulsors along with the flow field distribution of steady and unsteady results at different advance coefficients were compared. Moreover, the change of the lateral force and the difference between the abovementioned two methods were mainly analyzed. It was shown that the thrust and torque results of both methods were similar, with the lateral force results having the highest deviation     

激光陀螺标度因数误差对双轴旋转惯导系统的影响

研制高精度船用激光陀螺捷联惯导系统是惯性技术领域的重要发展方向之一,本文从旋转惯导系统与无旋转惯导系统误差方程的区别出发,详细讨论了双轴旋转惯导系统中激光陀螺标度因数误差的调制机理,仿真分析了对称性标度因数误差和非对称性标度因数误差在典型双轴旋转调制方案下的传播特性,为激光陀螺双轴旋转惯导系统的设计提供理论参考。     

Comparing prediction methods for maritime accidents

ABSTRACT

The purpose of maritime accident prediction is to reasonably forecast an accident occurring in the future. In determining the level of maritime traffic management safety, it is important to analyze development trends of existing traffic conditions. Common prediction methods for maritime accidents include regression analysis, grey system models (GM) and exponential smoothing. In this study, a brief introduction is provided that discusses the aforementioned prediction models, including the associated methods and characteristics of each analysis, which form the basis for an attempt to apply a residual error correction model designed to optimize the grey system model. Based on the results, in which the model is verified using two different types of maritime accident data (linear smooth type and random-fluctuation type, respectively), the prediction accuracy and the applicability were validated. A discussion is then presented on how to apply the Markov model as a way to optimize the grey system model. This method, which proved to be correct in terms of prediction accuracy and applicability, is explored through empirical analysis. Although the accuracy of the residual error correction model is usually higher than the accuracy of the original GM (1,1), the effect of the Markov correction model is not always superior to the original GM (1,1). In addition, the accuracy of the former model depends on the characteristics of the original data, the status partition and the determination method for the status transition matrix.     

绿色交通节能效益量化的问题与对策

研究了绿色交通节能效益量化的问题及其成因,提出了对策建议。     

考虑非稳态传热的高速汽油机主轴承润滑分析

针对一款高速汽油机主轴承内部润滑与摩擦磨损问题,考虑到轴承承载不均导致的轴瓦与润滑油非稳态传热,基于弹性流体动力润滑(EHD)和轴承动力学理论方法,通过迭代计算,得出该高速汽油机具有代表性的第三主轴承在最大转速(9500 r/min)时轴承内部精确的温度场与热变形,并以此为轴承新的几何轮廓边界条件分析轴承的实际润滑情况.结果表明,与未考虑轴瓦温度场及热变形相比,轴承润滑状态明显恶化,具体表现为轴承最小油膜厚度减小、最大油膜压力增大,且出现较严重的磨损.最后通过发动机台架试验测得轴承的实际工作情况,并与计算结果进行对比,计算结果与实际摩擦磨损情况吻合,验证了所用方法和所得研究结论的正确性.     

一种基于车辆运动状态估计的商用车侧翻预警方法

以商用车侧翻预警系统的开发为目标,提供一种实用的侧翻预警方法,提高车辆安全性。分析具备应用条件的车辆传感器,通过侧翻特性和侧翻相关车辆状态响应特性的分析,提出基于车速和转向的侧向运动状态估计方法,并设计基于转向盘转角和侧向加速度的侧翻预警融合算法,用于侧翻预警系统开发。     

使用UG NX4.0三维软件设计客车车架

客车车架是客车底盘的重要组成部分,通常是用二维软件设计,有一定的局限性。本文介绍使用UG NX4.0三维软件对车架进行设计。