REGULATION OF PRODUCTION OF PARATHYROID HORMONE－RELATED PEPTIDE （PTHrP） AND EXPRESSION OF ITS mRNA IN A HUMANLIVER－DERIVED CE

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Information needs of the continuing urban transportation planning process

Urban transportation is identified as a functional element in the broader context of urban facilities and services. From this point of view, the relative merits of separate information systems for transportation planning and general urban planning, as contrasted to unified systems for all urban management functions, are discussed. The overriding need to make the most effective use of urban resources argues strongly for the unification of urban information systems to the greatest possible extent consistent with the special data requirements of various functional programs. The need to identify and correlate data items for very small areal units and to keep current records of the constantly shifting patterns of social and economic activities in urban areas present difficult, but not insurmountable technical problems. However, the most serious barrier to the development and implementation of comprehensive urban information systems is concluded to be institutional, rather than technical, in nature.     

An application of variance reduction techniques in freeway simulation

Computer simulation models are used in a variety of applications in transportation engineering and have become a prime aid in decision making. The applications range from evaluating traffic control strategies for single intersections to such complex decision processes as evaluating the impact of removing toll facilities at the George Washington Bridge in New York City. While it is widely accepted that simulation offers an unmatchable capability of evaluating alternate control policies, the high variance of the output variable presents a critical problem in such comparative analyses. The simulation models with high output variance must be run longer or replicated many times to achieve a desired precision level, and that corresponds to increased cost of computer resources. This paper describes and illustrates the application of variance reduction concepts that can improve the reliability and efficiency of the simulation experimental process by taking advantage of the simulation model structure. The two variance reduction concepts (common random numbers and antithetic variates) reduce the variance of the output variable by replacing the original sampling procedure with a new procedure that yields the same expected value but with a smaller variance. The application of the variance reduction concept was illustrated using results from experiments with a freeway simulation model. The results indicate that both common random numbers and antithetic variates sampling procedures appreciably reduce the variance of the simulation output measure.     

Global cutting-path optimization considering the minimum heat effect with microgenetic algorithms

This article considers microgenetic algorithms (GAs), which explore in a small population with a few genetic operators, for cutting-path optimization problems. The major difference between GAs and simple genetic algorithms (SGAs) is how to make a reproductive plan for an improved searching technique because of population choice. It is shown that GAs implementation reaches the near-optimal region much earlier than the SGAs approach, and the GAs give a better solution than simulated annealing (SA). The main objective was to determine what temperature distribution can be obtained from the solution of a travelling distributed heat source. The solution of the travelling heat source on nested raw plate provides information about the vertices of each nested part of the raw plate. From the fact that the initial temperature at a piercing point strongly depends on the heat flow which stems from the previous cutting contour, the temperature of all piercing points must be lower than the critical temperature after each cutting of the components of a part. The critical temperature is identified as the mechanical melting temperature of steels. A heuristic back-tracking method is introduced to find the near-optimum cutting path considering the minimum heat effect on deformation. The heuristic back-tracking method is incorporated with the GAs.     

Roll Dynamics of Commercial Vehicles

An analytical model is developed here for studying the roll dynamics of commercial vehicles. Large displacements and rotations are accounted for in this nonlinear model so that it can be used for the study of roll dynamics well beyond the limits of wheel lift-off. The model is used to illustrate some of the dynamic phenomena in vehicle rollover, especially the interactive coupling between the roll and the vertical modes of motion. The influence of suspension backlash on rollover resistance is demonstrated, and the phenomenon of roll motion resonance is illustrated to suggest new means for evaluating vehicle rollover sensitivity.     

Comment Some reflections on port competition in the United States and western Europe

'Port competition' is a rather puzzling expression. This paper approaches it literally, searching for precise meanings. In seaports that contain complex and changeable mixtures of public and private enterprise, who competes and why? The answers to these questions are not conclusive but suggestive indications are found in the US, UK and northwestern Europe. Finally, we discuss what seem to be the key influential factors which may impact on the competitiveness of a port.     

A bi‐level programming approach — Optimal transit fare under line capacity constraints

The fare of a transit line is one of the important decision variables for transit network design. It has been advocated as an efficient means of coordinating the transit passenger flows and of alleviating congestion in the transit network. This paper shows how transit fare can be optimized so as to balance the passenger flow on the transit network and to reduce the overload delays of passengers at transit stops. A bi‐level programming method is developed to optimize the transit fare under line capacity constraints. The upper‐level problem seeks to minimize the total network travel time, while the lower‐level problem is a stochastic user equilibrium transit assignment model with line capacity constraints. A heuristic solution algorithm based on sensitivity analysis is proposed. Numerical example is used to illustrate the application of the proposed model and solution algorithm.     

Public transit subsidies, output effect and total factor productivity

This paper extends previous works on total factor productivity decomposition when firms receive both operating and capital subsidies. It shows that previous works considered either the lump-sum or substitution effects of these subsidies but not together. Using constrained cost minimization as the framework it offers formal proofs to show that cost increases are inevitable if the total effects of the subsidies are considered, and that total factor productivity growth results from increasing amounts of subsidies under economies of scale and in the absence of technical change. Applications of the decomposition equations derived to a sample of transit systems finds near constant returns to scale and negative contributions of these subsidies to total factor productivity growth. Technical change reverses this decline and results in total factor productivity growth. Further, it finds that the lump-sum effects of the subsidies reduce total factor productivity more than does the substitution effect.