考虑防撞墙影响的高速铁路桥梁声屏障及翼缘板上脉动力数值分析

以可压缩黏性流体的N-S方程和k-ε双方程湍流模型为基础,考虑防撞墙对空压的影响,采用计算流体力学软件PHOENICS,对高速列车行驶时作用在有防撞墙铁路桥梁声屏障和箱梁翼缘板上的脉动力分布进行数值分析.结果表明,列车车头驶入声屏障、经过声屏障中部区域和驶出声屏障时,声屏障各处脉动力时程曲线形式不同,脉动力沿声屏障高度的分布为先增大后减小,约在1/2声屏障高度处达到最大值;桥梁翼缘板上的脉动力峰值沿横桥向基本呈线性增大至防撞墙处;声屏障和桥梁翼缘板上的脉动力峰值与列车速度的平方呈线性关系.根据分析结果给出了脉动力峰值计算公式以及考虑脉动力的结构设计组合荷载.     

SD大鼠肝脏及附属管道的应用解剖

通过对150只成年SD大鼠肝脏及其附属管道的解剖学研究，明确了大鼠肝脏的位置、分叶、形态、韧带、管道系统及与周围脏器的毗邻关系，同时测量了肝脏各叶径线、重量百分比及肝脏附属管道的长度和直径。结果表明：大鼠肝脏分为6叶，即左外叶、左内叶、中叶、右叶、尾状叶、乳头叶，各叶县有相对独立的Glisson系统和肝静脉回流系统；各肝叶形态、比例较为恒定。本文还对以大鼠作肝胆疾病医学研究模型，如肝叶切除、肝脏再生、肝移植等的应用解剖问题进行了讨论。     

LEISHMANIA PROMASTIGOTES EVADE INTERLEUKIN 12 INDUCTION BY MACROPHAGES AND STIMULATE A BROAD RANGE OF CYTOKINES FROM CD_（4）~（＋

ＬＥＩＳＨＭＡＮＩＡＰＲＯＭＡＳＴＩＧＯＴＥＳＥＶＡＤＥＩＮＴＥＲＬＥＵＫＩＮ１２ＩＮＤＵＣＴＩＯＮＢＹＭＡＣＲＯＰＨＡＧＥＳＡＮＤＳＴＩＭＵＬＡＴＥＡＢＲＯＡＤ　ＲＡＮＧＥＯＦＣＹＴＯＫＩＮＥＳＦＲＯＭ　ＣＤ_（４）~（＋）ＴＣＥＬＬＳＤＵＲＩＮＧＩ...     

用动物模型定位、克隆复杂性疾病的易感基因:以类风湿关节炎动物模型为范例(续前)

3在大鼠关节炎模型上定位克隆易感基因在大鼠关节炎模型定位克隆易感基因,如图1所示:是将经典的纯系育种分离技术,结合congenic和重组系的建立,窄化易感区域,定位克隆基因,最终确定基因变异、功能变化和关节炎表型的关系[34-35]。具体步骤见图1。图1在大鼠关节炎模型上,定位克隆关节炎易感基因流程图Fig.1 Identification of susceptible genes to arthritis in rat models3.1选择亲代近交系,建立关节炎模型在数种关节炎模型中,用于进行基因定位克隆的模型有:胶原诱导性关节炎、油诱导性关节炎和Pristane诱导的关节炎。我们的研究工作主要…     

尼古丁损伤大鼠肠系膜动脉内皮功能及卡托普利的干预作用

目的观察尼古丁对大鼠离体肠系膜动脉内皮依赖性舒张反应的影响以及卡托普利的干预作用。方法应用器官培养技术和离体血管环张力描记法,研究不同浓度的尼古丁(10-5、10-4、10-3mol/L)在有或无卡托普利(0.01、0.030、.1 mmol/L)的情况下,对培养24 h的成年SD大鼠肠系膜动脉环(1 mm)内皮依赖性舒张反应的影响。结果尼古丁呈浓度依赖性损伤乙酰胆碱(ACh)诱导的内皮依赖性血管舒张反应(P<0.01,与空白对照组比较)。卡托普利呈浓度依赖性改善尼古丁对血管内皮依赖性舒张反应的损害。低浓度时对尼古丁损伤没有明显影响,高浓度具有显著的保护作用(P<0.05,与尼古丁10-4mol/L组比较)。结论卡托普利对尼古丁所引起的血管内皮依赖性舒张功能的损伤具有明显的保护作用。     

Numerical analysis of the dynamic interaction between wheel set and turnout crossing using the explicit finite element method

A three-dimensional (3-D) explicit dynamic finite element (FE) model is developed to simulate the impact of the wheel on the crossing nose. The model consists of a wheel set moving over the turnout crossing. Realistic wheel, wing rail and crossing geometries have been used in the model. Using this model the dynamic responses of the system such as the contact forces between the wheel and the crossing, crossing nose displacements and accelerations, stresses in rail material as well as in sleepers and ballast can be obtained. Detailed analysis of the wheel set and crossing interaction using the local contact stress state in the rail is possible as well, which provides a good basis for prediction of the long-term behaviour of the crossing (fatigue analysis). In order to tune and validate the FE model field measurements conducted on several turnouts in the railway network in the Netherlands are used here. The parametric study including variations of the crossing nose geometries performed here demonstrates the capabilities of the developed model. The results of the validation and parametric study are presented and discussed.     

Practicability study on the suitability of artificial,neural networks for the approximation of unknown steering torques

For steer-by-wire systems, the steering feedback must be generated artificially due to the system characteristics. Classical control concepts require operating-point driven optimisations as well as increased calibration efforts in order to adequately simulate the steering torque in all driving states. Artificial neural networks (ANNs) are an innovative control concept; they are capable of learning arbitrary non-linear correlations without complex knowledge of physical dependencies. The present study investigates the suitability of neural networks for approximating unknown steering torques. To ensure robust processing of arbitrary data, network training with a sufficient volume of training data is required, that represents the relation between the input and target values in a wide range. The data were recorded in the course of various test drives. In this research, a variety of network topologies were trained, analysed and evaluated. Though the fundamental suitability of ANNs for the present control task was demonstrated.     

One-dimensional model on fuel penetration in diesel sprays with gas flow

In diesel engine, spray penetration is usually changed by in-cylinder gas flow. Accurate prediction on diesel spray with gas flow is important to the optimal design of diesel fuel injection system. This paper presents a theory investigation focusing on the penetration of diesel spray with gas flow. In order to understand the effect of gas flow on the penetration of diesel spray, a one-dimensional spray model is developed from an idealized diesel spray, which is able to predict the spray behavior under different gas flow conditions. The ambient gas flow is simplified as ideal flow that has only constant flow velocity along x-axial and y-axial directions of spray. The x-axial and y-axial directions are respectively defined as along and vertical spray directions. The main assumption is that the y-axial direction gas flow has no effect on the penetration of spray along x-axial direction. The principles of conservation of mass and momentum are used in the derivation. Momentum of in-cylinder air flow is also taken into consideration. Validation of the model at stable condition is achieved by comparing model predictions with experimental measurements of diesel spray without gas flow from Naber's experiments. Furthermore, CFD simulations on penetration of diesel spray with gas flow were performed with the commercial code AVL-fire. The onedimensional model is validated by the penetration results with gas flow from CFD calculation. Results show that a reasonable estimation of the spray evolution can be obtained for both with and without ambient gas flow conditions.     

Estimation of maximum road friction coefficient based on Lyapunov method

With the real time and accurate information of motor torque and rotation speed of the four-in-wheel-motordrive electric vehicles, a slip based algorithm for estimating maximum road friction coefficient is designed using Lyapunov stability theory. Modified Burckhardt tire model is used to describe longitudinal slip property of the tire. By introducing a new state variable, a nonlinear estimator is proposed to estimate the longitudinal tire force and the maximum road friction coefficient simultaneously. With the appropriate selection of estimation gain, the convergence of the estimation error of the tire longitudinal force and maximum road friction coefficient is proved through Lyapunov stability analysis. In addition, the error is exponentially stable near the origin. Finally the method is validated with Carsim-Simulink co-simulation and real vehicle tests under multi working conditions in acceleration situation which demonstrate high computational efficiency and accuracy of this method.