Protective effect of glutamine pretreatment on ischemia-reperfusion injury of spinal cord in rabbits

Objective To investigate the effect of glutamine (Gln) on the content of reduced glutathione hormone (GSH) and aminoglutaminic acid (Glu) of spinal cord following ischemia-reperfusion injury. Methods Totally 40 healthy adult male rabbits were randomly divided into five groups: sham-operation group (S group), ischemia-reperfusion injury group (I/R group), low-dose glutamine group (L Gln group), median-dose glutamine group (M Gln group) and high-dose glutamine group (H Gln group). After glutamine preconditioning, the model of spinal cord ischemia-reporfasion injury was established according to Zivin's method. The general status of animals was observed and the changes of Jacobs scoring were recorded in each group. Malondialdehydes (MDA), GSH, Glu and superoxide dismutase (SOD) activity in lumbar spinal cord tissues were determined using chemical colorimetry. The neuron number and deviation rate in spinal cord anterior horn were observed histopathologically. Results There was no significant difference between L Gin group and I/R group in behavior scoring, SOD activity, content of MDA and Glu, neuron number and deviation rate of spinal cord (P>0.05); however, there was a significant difference in GSH content of spinal cord (P<0.05). M Gln group and I/R group differed significantly (P<0.05) in behavior scoring, SOD activity, content of MDA, Glu, GSH, neuron number and deviation rate of spinal cord. Between H Gln group and M Gln group, there was no significant difference in behavior scoring, content of MDA and Glu, SOD activity, neuron number and aberration rate in spinal cord (P>0.05), whereas there was a significant difference in SOD activity and Giu content (P<0.05). Conclusion Pretreatment with medium-dose glutamine has a protective effect on spinal cord ischemia-reporfasion injury in rabbits, which may be related to the maintenance of GSH content, increase of SOD activity and reduction of MDA.     

疲劳驾驶检测方法的研究进展

全世界每年因驾驶员疲劳驾驶而导致的死亡人数占交通灾难性事故的57%,故针对疲劳驾驶检测方法的研究具有现实意义.阐述了目前国内外各类疲劳驾驶检测方法的研究难点,介绍并对比分析了基于驾驶员生理参数、驾驶员行为特征、车辆行为特征的各类客观检测方法;最后对疲劳驾驶检测方法的发展趋势和应用前景进行了论述.     

铁路施工方案管理信息系统设计

介绍我国目前铁路线路施工方案编制和管理的现状,依据软件工程的理论,对铁路施工方案管理进行需求分析和数据流程分析,提出基于B/S模式的铁路施工方案管理信息系统架构模式.并对系统的设计目标、模块化结构、网络安全措施、数据库安全措施进行详细的分析与设计,最后简要阐述系统应用情况.     

铁路建设项目评价及分析系统的设计与实现

根据铁路目前的建设形势及项目评价工作的特点,设计研发了铁路建设项目评价及分析系统.从研发背景、系统功能、软件结构和系统特点进行了阐述.     

The measure and decision of technical risk in the development of naval vessels

The risks in development of navy vessels were explored, The resources of technical risk in the design and development of vessels were mentioned, It was pointed that technical risk dominated the other risk components. Based on the writers＇ understanding and experience from risk analysis and risk ,nanagement to the development of a navy vessel, four measure indexes of technical risk were presented. The decision criteria and the rules corresponding to the indexes were estahlished by the statistic information,     

EFFECTS OF ADENOSINE IN SIMULATED ISCHEMIA AND REPERFUSION ON ISOLATED GUINEA-PIG VENTRICULAR MYOCYTES

Adenosine (Ado) is an endogenous purine nu-cleoside that slows the sinus heart rate (negativechronotropic effect) as well as impulse conductionthrough the atrioventricular (AV) node (negativedromotropic effect )[1.2J. Two subtypes of adeno-sine receptors (A,, A,) have been identified basedon biochemical and radioligand binding studies inthe heart and pharmacology responses to Ado andadenosine derivatives. The predominant antiar-rhythmic effects on the sinoatrial (SA) node, AVnode, and atri…     

计算机编制列车运行图系统调整系统设计及实现

利用计算机编制列车运行图是铁路适应市场的需要,列车运行图编制系统的调整子系统是该系统的重要组成部分,对列车运行图系统的功能设计进行了讨论,对该子系统框架的设计以及图形显著优化的技术实现进行了详细地描述。     

The trade-off between trips and distance traveled in analyzing the emissions impacts of center-based telecommuting

Several travel indicators were compared between telecommuting (TC) days and non-telecommuting days for a sample of 72 center-based telecommuters in California. Distance traveled decreased significantly on TC days, with average reductions of 51 person-miles (58%) and 35 vehicle-miles (53%). When weighted by telecommuting frequency, average reductions of 11.9% in PMT and 11.5% in VMT were found over a five-day work week. Person-trips and vehicle-trips increased slightly (but not significantly) on TC days. This was due to statistically significant increases in commute trips by telecommuters (who more often went home for lunch on their TC days), partly counteracted by decreases in non-commute travel. The drive-alone mode share increased on TC days, both for all trips, and for commute trips in particular. Walking and biking shares also increased modestly on TC days, whereas shares of transit and ridesharing declined. Despite the increase in trip rates, TC-day reductions were found for all pollutants analyzed: 15% for total organic gas emissions, 21% for carbon monoxide, 35% for oxides of nitrogen, and 51% for particulate matter. The reduction in VMT more than compensated for the marginal increase in number of trips (and consequently, cold starts) on telecommuting days.     

浅析连续箱梁设计中的几个问题

结合工程实际,对连续箱梁设计计算中常遇到的几个棘手问题进行定量分析,并给出工程中实际可用的计算方法。     

海底单层保温管线总传热系数分析

总传热系数K是海底热油管道的运行管理中的一个非常关键的参数.文中通过对中海油涠洲11 -1油田至涠洲12 -1油田之间的海底管道总传热系数进行理论计算,并与投产前根据实际预热数据反算的总传热系数进行对比,得出理论计算的总传热系数与实际预热反算得到的总传热系数相近,同时指出海管接口的散热损失较大,海底管线应对接口部分进行...