伊辛模型实现量子态存储和调节

考虑利用腔QED理论模拟伊辛模型,双原子在腔中演化之后,可以实现特定量子态的稳定存储,调节相互作用时间和外驱动场的频率可以实现最大纠缠态的制备.     

三叶因子3在胃溃疡大鼠脾脏不同部位的表达

目的研究三叶因子3(TFF3)在胃溃疡大鼠脾脏不同部位的表达。方法胃前壁黏膜下注射冰乙酸制备大鼠胃溃疡模型,免疫组织化学法分别检测正常组(6只)和溃疡组(42只)雄性大鼠脾脏TFF3的表达。结果①溃疡组大鼠脾脏明显肿大、充血;与正常组相比白髓面积明显增大(P<0.05或P<0.01),至6 d组最大,边缘区增厚(P<0.05或P<0.01),至10 d组最厚;红髓面积减少。②TFF3阳性反应物呈棕黄色颗粒状分布于胞质中。③TFF3在正常组大鼠脾脏中呈弱阳性表达,在溃疡组表达明显增高(P<0.05或P<0.01)。溃疡组白髓中阳性细胞TFF3平均吸光度值各组与正常组相比明显增高(P<0.05),以10 d组增高最为明显;边缘区阳性细胞TFF3吸光度值1、2 d和6 d组与正常组相比明显增高(P<0.05或P<0.01),以6 d组增高最为明显;红髓阳性细胞TFF3吸光度值1、2、6 d和14 d组与正常组相比明显增高(P<0.05或P<0.01),以6 d组增高最为明显。④溃疡组边缘区TFF3表达与损伤时间呈负相关(P<0.05)。结论 TFF3在胃溃疡大鼠脾脏各部位呈高水平表达,可能通过提高脾脏免疫反应性促进胃溃疡的愈合。     

叶酸对冠心病大鼠血清同型半胱氨酸和血管内皮生长因子的影响

目的观察叶酸、维生素B12对冠心病大鼠模型血清同型半胱氨酸(HCY)、血管内皮生长因子(VEGF)的影响。方法将健康4周龄雄性SD大鼠60只(体重110±10g)随机分为正常对照组、高脂饮食组、叶酸组、维生素B12组、叶酸及维生素B12组。正常对照组给予普通饲料喂养;余各组给予高脂饲料喂养,第12周末测定各组大鼠血清血脂、HCY、VEGF含量;光镜、电镜查看腹主动脉组织学改变;利用Western blot检测各组大鼠腹主动脉中VEGF的表达。结果用药12周后,单独应用叶酸或联合维生素B12都能有效地降低冠心病模型大鼠血清HCY水平(P<0.01),升高血清和血管中VEGF水平(P<0.05),同时能改变VEGF的蛋白表达(P<0.05)。结论高脂饮食可以影响血清和血管中HCY、VEGF的水平,而应用叶酸或联合维生素B12可以改善或减轻高脂状态所造成的血管内皮损伤。     

T2DM患者外周血单个核细胞中NF-κB的表达变化及其相关因素的探讨

目的探讨无并发症的2型糖尿病(T2DM)患者外周血单个核细胞(PBMC)中核因子-κB/p65(NF-κB/p65)、核因子-κB抑制蛋白α(IκB-α)表达水平的变化及其与氧化应激、糖代谢等因素的关系。方法以无并发症T2DM患者30例、非糖尿病对照(NDM)30例为研究对象,测定其PBMC中NF-κB/p65、IκB-α蛋白表达水平,血清丙二醛(MDA)、超氧化物歧化酶(SOD)及糖化血红蛋白(GHb)等指标变化。结果与NDM组相比,T2DM患者NF-κB/p65表达升高;MDA水平升高,SOD活性降低。NF-κB/p65表达与MDA、GHb、稳态模型胰岛素抵抗指数呈正相关,与SOD呈负相关。T2DM患者与NDM间IκB-α蛋白表达无统计学差异。结论无并发症的T2DM患者PBMC中NF-κB/p65表达升高,其表达水平与氧化应激、血糖控制水平相关。     

长期应用糖皮质激素对大鼠股骨头骨组织MMPs/TIMPs系统的影响

目的观察长期应用糖皮质激素对大鼠股骨头骨组织中基质金属蛋白酶(MMPs)/基质金属蛋白酶组织抑制剂(TIMPs)系统的影响,探讨长期应用糖皮质激素导致股骨头坏死的相关机制。方法健康SD大鼠40只,雌雄各半,随机分为低、中、高剂量激素组和对照组,每组10只。低、中、高剂量组动物分别给予肌肉注射醋酸泼尼松龙7、12.5、25mg/kg体重,每周2次;对照组给予相同体积生理盐水肌注。4周后取左侧股骨头骨组织石蜡包埋,HE染色,鉴定股骨头坏死情况;取右侧股骨头骨组织提取总RNA,采用实时定量聚合酶链反应(RT-PCR)技术检测MMP-2、MMP-9、TIMP-1、TIMP-2mRNA表达水平。结果高、中、低剂量激素组和对照组动物初期股骨头坏死发生率分别为83.33%(5/6)、66.67%(6/9)、30%(3/10)、0(0/10);各激素组与对照组比较,MMP-2、MMP-9mRNA表达增高,与激素用量呈正相关,其中,中、高剂量激素组与对照组比较,差异有统计学意义(P<0.05);TIMP-1、TIMP-2mRNA表达水平降低,且与激素用量呈负相关,差异有统计学意义(P<0.05)。结论长期应用糖皮质激素致股骨头坏死的效应可能与其调控MMPs/TIMPs系统表达有关。     

路难走还是走路难?

基于目前步行交通在国内城市面临的困境,首先从步行行为分析、影响因素以及步行速度、步行环境等方面阐述了对步行交通的基本认识.然后从城市规划与交通规划的角度,剖析了步行交通系统严重匮乏的表面症结与深层次问题,指出以往的城市与交通规划理念以及城市土地开发设计,严重破坏了城市原有机理与步行空间.最后强调在以人为本和节约资源的前...     

U.S. import/export container flow modeling and disruption analysis

International containerized freight movement is a vital part of the supply chain for many companies, and a critical element of moving consumer goods to points of retail sale within the U.S. Containerized imports also present a clear security concern (e.g., terrorists attempting to ship “dirty bombs,” chemical, biological or even nuclear weapons, into the U.S. in a shipping container). The goal of the research presented here is to create a modeling tool for analyzing flows of U.S. imports and exports of containerized freight, and the potential changes in those flows under a variety of conditions (e.g., port disruptions, extensive security-related delays, etc.). Our focus is on movements through maritime container ports, and not overland movements between the U.S. and Canada or Mexico.The network model, referred to as the System for Import/Export Routing and Recovery Analysis (SIERRA), represents container movements between the U.S. and 46 other countries that account for the vast majority of U.S. imports and exports. The SIERRA model is a network equilibrium model that predicts flows between foreign countries and North American ports, the total volumes handled (import and export) by each port, the modal volumes (truck and rail) moving domestically into and out of each port, and volumes between each port and a set of transportation analysis zones within the U.S.     

级配碎石基层施工关键技术

对级配碎石基层的级配和施工工艺进行了系统的研究,并通过对比5种试验路方案来确定级配碎石基层与沥青混凝土中面层之间的黏结层,即:煤油稀释沥青透层、SBR改性乳化沥青黏层油、煤油稀释沥青透层+SBR改性乳化沥青黏层油、煤油稀释沥青透层+SBS改性沥青碎石封层、高渗透乳化沥青透层油的使用效果,最终推荐采用高渗透乳化沥青透层油的黏结层方案,并得出了一些关于级配碎石基层施工的关键技术成果。     

水面舰艇基本通信能力的效能评估

水面舰艇的基本通信能力是舰艇通信系统效能的重要方面,根据通信设备的工作特性,对舰艇的基本通信能力按业务类型分类,并运用层次分析法的思想构建了指标体系,对水面舰艇的基本通信能力进行效能评估.结果证明了该方法的可行性,此方法也可为下一步系统通信效能分析提供参考.     

Correcting for endogeneity in behavioral choice models with social influence variables

While psychologists and behavioral economists emphasize the importance of social influences, an outstanding issue is how to capture such influences in behavioral models used to inform urban planning and policy. In this paper we focus on operational models that do not require explicit knowledge of the individual networks of decision makers. We employ a field effect variable to capture social influences, which is calculated as the percent of population in the peer group that has chosen the specific alternative. We define the peer group based on socio-economic status and spatial proximity of residential location. As in behavioral economics and psychology, the concept is that one is influenced by the choices made by one’s peers. However, using such a social influence variable in a behavioral model causes complications because it is likely endogenous; unobserved factors that impact the peer group also influence the decision maker, yielding correlation between the field effect variable and the error. The contribution of this paper is the use of the Berry, Levinsohn, and Pakes (BLP) method to correct the endogeneity in a choice model. The two-stage BLP introduces constants for each peer group to remove the endogeneity from the choice model (where it is difficult to deal with) and insert it into a linear regression model (where endogeneity is relatively easier to deal with). We test the method using a mode choice data set from the Netherlands and readily available software and find there is an upward bias of the field effect parameter when endogeneity is not corrected. The procedure outlined presents a practical and tractable method for incorporating social influences in choice models.