城市交通公平性分析及对策

城市道路的交通公平性有利于建设和谐、公平的城市,在交通公平的定义以及它的三层含义的基础上,陈述了交通公平在时间、空间和内容上的内涵。分析城市道路交通公平的影响因素及其判断标准,阐述了快速公交符合城市道路交通公平的判断标准是它有利于大多数人的出行,满足弱势群体的出行要求,并应具有低成本、高质量的优点。最后,以北京市BRT的实践表明快速公交是提高城市交通公平性的有效措施。     

英国职业教育特色与启示

文章介绍了中英职业教育合作项目的背景与进展,研究了英国当前的职业教育状况,分析了先进的教育经验．并对合作项目下的汽修课程体系改革作出了规划。     

快速老化小鼠的学习记忆缺陷及其生化机制

目的用快速老化小鼠(SAMP8)模拟老年痴呆,观察其学习记忆能力,并探讨其学习记忆能力下降的可能机制。方法采用10月龄SAMP8,并用同龄抗快速老化小鼠(SAMR1)作为正常对照。用水迷路检测近记忆以及空间学习记忆能力。用生物化学方法检测大脑皮层线粒体膜电位和ATP酶活力,观察线粒体功能;检测皮层和海马胆碱乙酰基转移酶(ChAT)和乙酰胆碱酯酶(AChE)的活力,观察中枢胆碱能神经功能;检测血清超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量,观察其全身性氧化应激状况。结果与SAMR1相比,SAMP8出现明显的衰老体征,其近记忆和空间学习记忆能力明显减弱,具有衰老和痴呆特征;皮层线粒体膜电位和ATP酶活力显著降低,海马ChAT活力显著下降,AChE活力显著升高,血清SOD活力稍有增高。结论SAMP8可以很好地模拟老年痴呆,其机制包括大脑皮层线粒体功能降低、海马胆碱能神经功能下降以及氧化应激等。     

QoS awared power and admission controls based on non-cooperative game theory in wireless networks

In order to better accommodate heterogeneous quality of service (QoS) in wireless networks, an algorithm called QeS-aware power and admission controls (QAPAC) is proposed. The system is modeled as u non- cooperative game where the users adjust their transmit powers to maximize the utility, thus restraining the interferences. By using adaptive utility functions and tunable pricing parameters according to QoS levels, this algorithm can well meet different QoS reqniremcnts and improve system capacity compared with those that ignore the QoS differ- ences.     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

基于CFD模拟的船舶空调舱室热舒适性研究

针对船舶舱室热环境的特殊性,建立了适用的CFD计算模型,并对其进行了实验验证。在该模型的数值模拟结果基础上,以PMV-PPD热舒适性评价指标和DNV COMF-C(3)规范为依据,对船舶舱室空调气流组织进行优化。优化结果表明,相比于优化前,优化后的餐厅和会议室的热舒适性得到改善,热环境满意人数分别增加了52.7%和28.9%。结合CFD模拟和热舒适性评价分析的优化方法,在节约时间和实验成本的同时,为船舶空调系统的设计和优化提供了重要依据。     

飞机防冰腔结构参数的重要性测度

分析了常见的3种飞机防冰腔结构,应用Gambit软件建立了双蒙皮防冰腔结构网格模型。采用Spalart-Allmaras湍流模型模拟热气在防冰腔内的流动状况,采用Fluent软件进行传热效率分析,建立了防冰腔结构参数对传热效率的重要性测度模型。通过随机响应面法建立防冰腔结构参数与传热效率的函数关系,采用低分散性抽样法求解防冰腔结构参数的重要性测度,建立了防冰腔结构参数的重要性测度分析流程。分析结果表明:当笛形管中心到外蒙皮的距离从35.15mm增加到38.85mm时,传热系数由0.505减小到0.463;当双蒙皮通道高度从2.85mm增加到3.15mm时,传热系数由0.495减小到0.476;当射流孔孔径从1.90mm增加到2.10mm时,传热系数从0.505减小到0.494;当射流孔角度从14.25°增加到15.75°时,传热系数从0.476增加到0.494。防冰腔结构参数的重要性排序依次为射流孔角度、笛形管中心到外蒙皮距离、射流孔孔径、双蒙皮通道高度,在防冰腔结构加工与装配过程中,需要重点考虑射流孔角度与笛形管中心到外蒙皮距离这2个参数。     

EA4T车轴钢的超声冲击表面强化

利用超声冲击设备对EA4T车轴钢进行了表面强化处理.采利用金相显微镜和透射电镜表征了车轴钢表面结构的变化,并对超声冲击处理前后试样表面粗糙度和显微硬度进行了分析.结果表明:经超声冲击处理后,试样表面发生了剧烈的塑性变形,晶粒明显细化,显微硬度呈梯度化.随着超声冲击功率的增加,变形层厚度增加,粗糙度减小,表面硬度增大;与未经超声冲击处理的试样相比,在超声冲击功率180瓦作用下,表面粗糙度降低了6.5倍,试样的表面硬度提高了25%,变形层厚度大约为80μm.     

大连市主城区停车分区供给策略研究

随着大连机动车保有量快速增长,城区规模不断扩大,主城区内停车问题逐渐凸显,且呈现出区域差别化的特点.在总结其他城市经验的基础上,结合大连城市发展现状及规划,划定停车分区,提出各分区停车设施供给策略,为大连城市未来停车系统的发展提供参考.