复杂产品协同设计过程建模方法研究

通过分析新型自驱动式牵引机的开发过程，提出对复杂产品协同设计过程模型的要求；引用协同工作过程建模方法——MCM，提出了“分层MCM”协同设计过程建模方法，并应用于新型自驱动式牵引机协同设计过程。     

CRC通用校验测试工具的设计与实现

CRC(循环冗余校验码)编码是数字信号传输中用得较普遍的一种差错控制编码.它不但可以用于纠正独立的随机错误,也可以用于纠正突发错误.目前已有的CRC校验算法程序很多,但往往只以一种生成多项式为例进行编写,缺少完整、通用性好、用户界面良好的应用软件.介绍了一种CRC通用校验测试工具的设计与实现过程,本测试工具将各种类型的CRC校验算法进行汇总,类型全、计算精度高、速度快、用户界面好、易操作.     

一种基于软件预测的IPv6平滑切换技术的研究

对当前移动IPv6的切换技术进行了分析,包括标准移动IPv6切换技术、层次移动IPv6管理方案等技术.分析了这些技术的工作原理及其运作的优缺点.并提出一种改进的基于软件预测的移动IPv6平滑切换机制,对该机制的原理和实现做了阐述,给出模拟实验数据并做出比较.     

半刚性基层沥青路面反射裂缝防治措施探讨

反射裂缝是半刚性基层沥青路面的主要病害之一,它不仅降低路面的使用性能,影响行车舒适性,而且也影响到路基的强度和稳定性。笔者在介绍反射裂缝概念基础上,简要叙述了反射裂缝形成机理及扩展规律的几种理论。针对裂缝形成机理,笔者总结出几种防治反射裂峰的措施。     

替加色罗对结肠炎大鼠内脏敏感性的影响及其与结肠内P物质和降钙素基因相关肽表达的关系

目的评价替加色罗对结肠炎大鼠内脏敏感性的影响,并探讨其调节内脏敏感性的作用途径。方法成年雄性SD大鼠42只,经三硝基苯磺酸(TNBS)灌肠诱导结肠炎后随机分为4个实验组和4个对照组:其中3个结-直肠扩张(CRD)实验组(n=6)及3个CRD对照组(n=4)分别给大鼠替加色罗和生理盐水灌胃,在灌胃3、7、14 d后记录腹壁肌电活动;1个免疫组化(IH)实验组(n=6)及其对照组(n=6)分别在替加色罗和生理盐水灌胃7d后,采用免疫组织化学法观察大鼠结肠内P物质(SP)和降钙素基因相关肽(CGRP)的表达。结果替加色罗灌胃3 d后,在1.2、1.6mL扩张容量下,大鼠腹肌收缩次数(6.00±1.10,3.17±0.98)较对照组明显减少(9.50±2.52,13.0±2.31,P<0.05)。替加色罗连续灌胃7 d和14 d后,在0.4、0.8、1.2、1.6 mL扩张容量下,大鼠腹肌收缩次数均明显少于对照组(P<0.01)。替加色罗灌胃7 d后,结肠内SP染色评分下降,而CGRP染色强度与对照组比较无明显变化。结论替加色罗可以明显降低结肠炎大鼠对结肠球囊扩张刺激的敏感性,其降低内脏敏感性的作用可能与其抑制胃肠道内脏感觉传入神经表达SP有关。     

Study of the mechanism on the apoptosis induced in Human leukemia cell line K562 by the combination of indole-3-acetic acid and horseradish peroxidase

Objective To investigate the mechanisms of apoptosis induced in Human leukemia cell line K562 by the combination of indole-3-acetic acid and horseradish peroxidase. Methods Human leukemia cell line K562 were exposed to indole-3-acetic acid （IAA） at 20, 40, 60, 80 or 100 mol/L and horseradish peroxidase（HRP） at 1.2 g/mL for varying times. MTT assay was applied to detect the cell proliferation. Flow cytometry was performed to detect the arrest of cell cycle. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling （TUNEL） assay was used to measure apoptosis. 2, 7-dichlorofluorescin diacetate （DCFH-DA） uptake was measured to determine free radical by confocal microscope. Content of malondiadehyde （MDA） and activity of superoxide dismutase （SOD） were measured by biochemical methods. Results IAA/HRP initiated growth inhibition of K562 cells in a dose- and time-dependent manner. Flow cytometry revealed that cell cycle arrested at G1/G0 after 24 hours treatment. After 72 hours treatment, apoptotic rate of 100 mol/L IAA group increased to 43.9 %, which was 5 times that of control（P〈0.01）. Content of MDA and activity of SOD increased respectively in treatments compared with control. Meanwhile, IAA/HRP stimulated the formation of free radical, which was increased by IAA concentration-dependently. Conclusion The combination of IAAand HRP can inhibit the growth of Human leukemia cell line K562 in vitro by inducing apoptosis which is associated with the increase of free radical. The combination of IAA and HRP might be a promising chemopreventive and chemotherapeutic agent against human leukemia.     

塑料排水板加固高速公路软土路基效果分析

以河北沿海高速公路软土路基塑料排水板超载预压法处理深厚软基的试验结果为基础,对用该方法处理深厚软基的沉降、孔隙水压力、及深层水平位移的变化规律及固结系数进行了分析。     

ZA4-1/ZL102双金属复合材料的挤压铸造研究

研究了ZA4-1/ZL102双金属复合材料界面的显微组织,挤压铸造过程中锌合金预热温度和挤压压力对复合材料的影响.用固态锌基合金ZA4-1与液态铝基合金ZL102进行固-液复合,从而得到性能更好的复合材料.在挤压铸造成形理论指导下,通过合理控制其参数设置,使得ZA4-1/ZL102复合材料的组织更加细密.铝合金原子挣脱结构内部的束缚渗透到了锌合金的组织中,得到一种新型的复合材料,实现了在挤压铸造工艺下的双金属复合.     

Numerical analysis and experimental study of the effect of workpiece thickness on flow field in laser cutting

Based on Navier-Stokes equation and renormalization group (RNG) onflow model, the 3D symmetrical impinging jet model of laser cutting is established by adopting a taper nozzle and a convergence nozzle. Numerical simulation of gas flow in laser cutting is used to investigate the effect of workpiece thickness on flow field of assist gas in cutting slot. The isolines of static pressure as well as the distributions of static pressure and velocity are analyzed in details with different workpiece thickness, and the trend of dynamics characteristics of gas jet is shown in the study. For taper nozzles and convergence nozzles, the dynamic structure of assist gas being close to the lower surface of workpiece is exacerbated while the cutting quality and cutting efficiency become worse with the increasing of workpiece thickness. The parallel degree between assist gas and the axis of convergence nozzle is better than that of taper nozzle after the gas goes out of the nozzles. Two typical subsonic nozzles are designed for the cutting experiment at the end of the paper.