肿瘤浸润淋巴细胞和重组人白细胞介素-2对进展期肿瘤患者细胞免疫功能的影响

对20例经手术切除的进展期肿瘤患者用活化的肿瘤浸润淋巴细胞（TIL）和重组人白细胞介素-2（rhIL－2）治疗，检测治疗前后细胞免疫功能变化。其中8例治疗后PBL对同种异体相同组织学类型靶细胞的细胞毒性从43．2升高到1249．0溶解单位（P＜0．05），而NK活性无明显变化；T4、T8淋巴细胞亚群荧光强度明显升高，从1．9到3．9（P＜0．05）及4．4到7．2（P＜0．05）。所有患者PPD及PHA反应性明显增强，从10．9mm到13．6mm（P＜0．01）及7．9mm到12．7mm（P＜0．01），15例有一过性寒战、发热，其中10例伴轻度恶心、呕吐。结果提示：TIL和rhIL－2治疗后可明显提高进展期肿瘤患者的细胞免疫功能，而无明显毒副作用，可能成为进展期肿瘤术后重要的辅助治疗方法。     

软土地基高速公路养护工程纵面线形技术标准探讨

高速公路养护工程纵面线形标准对高速公路服务水平、养护经费影响甚大,文章分析了软土地区高速公路养护工程采用不同纵面线形标准对道路行驶质量、养护工程造价的影响,分析表明采用小坡长技术标准结合实际路面拟合纵面线形技术可行,经济效益明显。     

江苏高速公路沥青路面典型结构环道车辙试验

针对江苏省高速公路沥青路面存在的车辙问题,通过足尺环道试验,系统地研究江苏省高速公路沥青路面典型结构的沥青混合料的抗车辙能力,评价不同结构组合的沥青路面抗车辙性能。     

基于VISSIM的交叉口信号控制优化

城市十字路口较多,加之信号配时不合理,车辆通过就会干扰频繁,使得延误时间过长,十字路口的通过量低.文章以桂庙村口交叉口为例,在对该路口交通流量数据调查的基础上,运用VISSIM建立微观仿真模型,检验仿真与现实路口的相似度,通过“等效交通量”方法优化配时方案,并对优化前后的配时方案进行仿真评价.仿真结果表明：优化方案使得交叉口停车时间下降了10.96％,平均排队下降了15.82％,通过车辆数增加了12.92％,说明优化配时方案能够有效提高该交叉口的服务水平,提高通行率.     

基于DCP检测的农村公路路基施工控制技术研究

控制路基施工质量的传统方法和先进技术都有一定的局限性,通过总结国内外的资料以及室内试验,研究了动态圆锥贯入（DCP）检测所得的贯入比率PR和加州承载比CBR、土基回弹模量Eo以及土基压实度的关系。从而得出采用动态圆锥贯入仪控制农村公路的路基施工质量具有良好的适用性。     

丹参对恶性梗阻性黄疸治疗作用的实验研究

目的研究丹参对实验性梗阻性黄疸型肝癌发展的影响。方法SD大鼠肝门部肝实质种植Walker-256癌株瘤块,建立恶性梗阻性黄疸模型。将模型鼠分成4组:生理盐水组(n=24)、肌苷+VC组(n=40)、丹参组(n=40)及5-FU组(n=40)。通过腹腔内分别注射生理盐水、肌苷+VC、丹参及5-FU,观察肝功、肝组织形态学及肝癌、癌周、临近肝叶及肺组织中增殖细胞核抗原(PCNA)、血管内皮生长因子(VEGF)及细胞间黏附分子-1(ICAM-1)的表达情况。结果①丹参组对肝功的保护作用明显优于生理盐水组和5-FU组(P<0.01),而与肌苷+VC组相比无显著性差异(P>0.05);同时丹参组对梗阻性黄疸所致的组织形态学损害产生保护作用。②丹参组抑癌率和抑转移率均明显高于生理盐水组和肌苷+VC组(P<0.01);而与5-FU组相比无显著性差异(P>0.05)。③丹参组肝癌、癌周、临近肝组织及肺组织中PCNA、VEGF、ICAM-1的表达均低于肌苷+VC组和生理盐水组(P<0.01);与5-FU组比较,PCNA和VEGF无显著性差异(P>0.05),而ICAM-1则有显著性差异(P<0.05)。结论丹参对恶性梗阻性黄疸的肝脏损害有保护作用,而且通过抑制肝癌细胞增殖、阻碍肿瘤血管的形成及防止肝内外转移等机制而表现出抗癌作用。     

厦门市北溪引水主干渠结构断面设计分析

北溪引水主干渠为厦门市的供水主动脉,考虑到土地规划的需求以及供水升级的必要性,现对其马銮湾段进行升级改造。主干渠供水规模为16 m³/s,断面形式采用双孔钢筋混凝土箱涵。遵循断面设计需与地基适应性强,与原旧箱涵衔接方便等原则,将主干渠分为4种断面规格;并对其进行有限元计算分析,计算得出相应箱涵内力与抗浮成果。     

Improved Parallel Three-List Algorithm for the Knapsack Problem without Memory Conflicts

Based on the two-list algorithm and the parallel three-list algorithm, an improved parallel three-list algorithm for knapsack problem is proposed, in which the method of divide and conquer, and parallel merging without memory conflicts are adopted. To find a solution for the n-element knapsack problem, the proposed algorithm needs O（2^3n/8） time when O（2^3n/8） shared memory units and O（2^n/4） processors are available. The comparisons between the proposed algorithm and 10 existing algorithms show that the improved parallel three-fist algorithm is the first exclusive-read exclusive-write （EREW） parallel algorithm that can solve the knapsack instances in less than O（2^n/2） time when the available hardware resource is smaller than O（2^n/2） , and hence is an improved result over the past researches.     

液基细胞学和传统涂片法在痰液标本诊断肺癌中的价值比较

目的评价液基细胞学在痰液标本中的应用价值。方法对临床送检的287例痰液标本行液基细胞学方法处理,并与传统涂片方法进行比较分析。结果液基细胞学和传统涂片法检出肺癌的灵敏度分别为21.6%(62/287)和17.1%(49/287),两者相比差异无统计学意义;但两种方法联用灵敏度可达24.0%,与传统涂片法相比差异有统计学意义(P<0.05),而与液基细胞学方法比较差异不显著。液基细胞学和传统涂片法诊断肺癌的假阴性率分别为38.6%和48.5%,两者相比差异无统计学意义;但两种方法联用假阴性率为31.7%,与传统涂片法相比差异有统计学意义(P<0.05),而与液基细胞学方法比较差异不显著。结论通过痰液标本检测肺癌细胞,液基细胞学要好于传统涂片法,具有明显的优越性;两者联用可提高肺癌的检出率,值得临床大力推广。     

Effect of temperature- and frequency-dependent dynamic properties of rail pads on high-speed vehicle–track coupled vibrations

The soft under baseplate pad of WJ-8 rail fastener frequently used in China’s high-speed railways was taken as the study subject, and a laboratory test was performed to measure its temperature and frequency-dependent dynamic performance at 0.3?Hz and at ?60°C to 20°C with intervals of 2.5°C. Its higher frequency-dependent results at different temperatures were then further predicted based on the time–temperature superposition (TTS) and Williams–Landel–Ferry (WLF) formula. The fractional derivative Kelvin–Voigt (FDKV) model was used to represent the temperature- and frequency-dependent dynamic properties of the tested rail pad. By means of the FDKV model for rail pads and vehicle–track coupled dynamic theory, high-speed vehicle–track coupled vibrations due to temperature- and frequency-dependent dynamic properties of rail pads was investigated. Finally, further combining with the measured frequency-dependent dynamic performance of vehicle’s rubber primary suspension, the high-speed vehicle–track coupled vibration responses were discussed. It is found that the storage stiffness and loss factor of the tested rail pad are sensitive to low temperatures or high frequencies. The proposed FDKV model for the frequency-dependent storage stiffness and loss factors of the tested rail pad can basically meet the fitting precision, especially at ordinary temperatures. The numerical simulation results indicate that the vertical vibration levels of high-speed vehicle–track coupled systems calculated with the FDKV model for rail pads in time domain are higher than those calculated with the ordinary Kelvin–Voigt (KV) model for rail pads. Additionally, the temperature- and frequency-dependent dynamic properties of the tested rail pads would alter the vertical vibration acceleration levels (VALs) of the car body and bogie in 1/3 octave frequencies above 31.5?Hz, especially enlarge the vertical VALs of the wheel set and rail in 1/3 octave frequencies of 31.5–100?Hz and above 315?Hz, which are the dominant frequencies of ground vibration acceleration and rolling noise (or bridge noise) caused by high-speed railways respectively. Since the fractional derivative value of the adopted rubber primary suspension, unlike the tested rail pad, is very close to 1, its frequency-dependent dynamic performance has little effect on high-speed vehicle–track coupled vibration responses.