描述有效的原料药

尽管癌症治疗在过去的十多年取得了显著进展，但肿瘤学仍属于目前最不能满足临床需要的学科领域。在过去十多年里，临床药理学的进步和研发活动方面的巨大投资使得“癌症治疗”发展为“治疗过程研究”的数量急剧增加。但事实上，癌症和其他慢性疾病一样，治疗效果都很差，由此很多大型医药公司和生物制药公司都比以往更大力度的投入资金，用于肿瘤学和其他强效候选药物的研发上。[第一段]     

Modelling inter-urban transport flows in Italy: A comparison between neural network analysis and logit analysis

In the present paper a modal split problem is analysed by means of two competing statistical models, the traditional logit model and the new technique for information processing, viz. the feedforward neural network model. This study aims to explore the modal split between rail and road transport modes in Italy in relation to the introduction of a new technological innovation, the new High-Speed Train. The paper is sub-divided into two major parts. The first part offers some general considerations on the use of neural networks in the light of the increasing number of empirical applications in the specific area of transport economics. The second part describes the Italian case study by using the two above mentioned statistical models. The results highlights the fact that the two adopted models, although methodologically different, are both able to provide a reasonable spatial forecasting of the phenomenon studied. In particular, the neural network model turns out to have a slightly better performance, even though there are still critical problems inherent in its application.     

氢燃料内燃机技术现状与发展展望

介绍了氢气及氢燃料内燃机的特点及氢燃料内燃机的技术现状。通过对比分析指出氢燃料内燃机既可以采用清洁可再生能源,又可以充分利用现有的庞大工业体系,是实现氢气经济的现实途径。     

European freight transport and the environment: empirical applications and scenarios

Environmental issues have received a prominent place in transport policies of most European countries. The coordination of such policies however, is fraught with many difficulties. The increasing freight flows after the European integration are a source of concern, but have not yet led to straightforward and effective environmental strategies.The paper focuses on the Trans Alpine freight transport systems in the light of the future integration of single national transport systems into the European transport network. The environmental, social and institutional peculiarities of this ‘region’ have favoured—in the past—the development of strong nationally-oriented policies, partly in contrast with the goals promoted by the European Union. The present analysis aims to highlight opportunities, and limits inherent, in the implementation of various infrastructure projects oriented towards a drastic change of the Alpine transport systems structure. The Alpine countries, viz. Austria and Switzerland, play a central role in the promotion of environmental benign modes of transport of goods, with a clear focus on rail. The route choice and modal split of freight flows in Europe are taking place simultaneously. In this paper the results of European freight flow models (based on logit analysis and neural networks) will be presented. An important exercise is then to assess the consequences of various types of eco-taxes on road transport in Europe. In this context, several policy scenarios will be dealt with.     

On the application of hydraulic theory to the deep-water flow through the Irbe Strait

A flow-dependent critical-point method for investigating topographically controlled flow in natural channels is applied to the bottom current through the Irbe Strait connecting the Baltic proper and the Gulf of Riga. This approach is based on the functional formalism due to Gill [Gill, A.E., 1977. The hydraulics of rotating-channel flow. J. Fluid Mech., 80, 641–671.], and here is used for the stratified flow structure observed during the IRBEX-95 field campaign. A critical section of the realizable flow regime was found to be located slightly downstream of the most pronounced horizontal constriction of the channel. The predicted baroclinic volume flux 7200 m³ s⁻¹ overestimates the observed mean bottom-water transport by around 30%, a discrepancy which most likely can be explained by the lack of sea level conditions and friction in the model.     

Ballast Water Treatment systems: “Old” and “New” ones

This paper offers an overview of the currently available Ballast Water Treatment systems, their efficacy in reducing the number of organisms in relation with the IMO and other, future standards, and explores potentially new and promising technologies and current gaps.     

Towards comfort-optimal trajectory planning and control

ABSTRACT

This paper describes a method to analyse and evaluate different trajectory planning methods and controller types for usage in automated vehicles. Its application is shown by using a novel trajectory planning approach considering comfort aspects (based on Rapidly Exploring Random Tree (RRT)), two different controllers to follow the planned path (cascade controller and flatness based controller) and a simulation method to obtain resulting lateral vehicle accelerations. The method is used to plan and drive a trajectory through a roundabout. It can be seen that the lateral accelerations of the controller-driven vehicle are in the range of the values used for planning. However, the results of both controllers show differences in lateral deviation and in smoothness of lateral accelerations. The simulation results are then compared to real-world test drives in the same roundabout. The measured lateral accelerations are in the same range as well but show a smoother progression than the two controller models.     

Identification of potential sites for deep-ocean waste isolation with a geographic site-selection model

Identification of optimal sites for the isolation of waste on the abyssal seafloor was performed with two approaches: by the traditional method of map overlays of relevant attributes, and by a specially developed, automated Site-Selection Model (SSM). Five initial, Surrogate Sites, identified with the map-overlay approach, were then compared with the more rigorously produced scores from the SSM. The SSM, a process for optimization of site locations, accepts subjective, expert-based judgments and transforms them into a quantitative, reproducible, and documented product. The SSM is adaptable to any siting scenario. Forty-one factors relevant to the isolation scenario, including 21 weightable factors having a total of 123 scorable categories, have been entered into the SSM. Factors are grouped under project definition, unique environments, anthropogenic, geologic, biologic, weather, oceanographic and distance criteria. The factor scores are linked to a georeferenced database array of all factors, corresponding to 1°×1° latitude–longitude squares. The SSM includes a total of 2241 one-degree squares within 1000 n.m. of the U.S. coasts, including the western North Atlantic, the Gulf of Mexico, and the eastern North Pacific. Under a carefully weighted and scored scenario of isolation, the most favorable sites identified with the SSM are on the Hatteras and Nares Abyssal Plains in the Atlantic. High-scoring sites are also located in the Pacific abyssal hills province between the Murray and Molokai Fracture Zones. Acceptable 1° squares in the Gulf of Mexico are few and of lower quality, with the optimum location on the northern Sigsbee Abyssal Plain. Two of the five Surrogate Site locations, on the Hatteras and Sigsbee Abyssal Plains, correspond to the best SSM sites in each ocean area. Two Pacific and a second Atlantic Surrogate Site are located in low-scoring regions or excluded by the SSM. Site-selection results from the SSM, although robust, are an initial attempt to quantify the site-selection process. The SSM database exposes a significant lack of high-quality information for many areally mappable attributes on the abyssal seafloor, particularly bottom-current speed and measures of biologic productivity and flux. Terminologies and classifications of some measures, such as sediment types, suffer from parochialism and vary by ocean. Considerable research is needed even for a broad understanding of the environmental measures required to make sound societal decisions about use of the abyssal seafloor for disposal or other purposes.