载货汽车主气瓶不同气压时制动性能分析

汽车综合性能测试仪VGQT测试分析结果表明,货车在主制动气瓶压力不同时,各轴制动气室所能达到的最大压力也不相同[1],除此之外,本试验中N类载货汽车0型制动试验表明,主气瓶气压不同时,各轴气室制动压力变化曲线以及有效最大减速度MFDD也不相同。载货汽车绝大部分是用于长途运输,尤其是N2、N3类载货汽车,由于其满载质量大,长途运输中制动效能对于行驶安全性有着很大的影响,尤其在我国西南部山道纵横,长时间上下坡很容易造成制动器的热衰退,这是引起交通事故的主要诱因之一[2,3]。本文以实际试验结果为研究对象,分析了主气瓶在不同压力下各轴制动气室压力的变化以及0型制动试验中制动气压曲线的变化和有效最大减速度的变化,这对于行驶安全性和燃油经济性都有一定的意义,进而对排放和环境造成影响。     

不锈钢车体钝化工艺研究

针对轨道交通车辆在制造过程中,不锈钢车体表面的钝化膜因机加工、焊接等因素可能遭到破坏,导致不锈钢车体防腐能力下降的情况,详细介绍了不锈钢车体的钝化原理、钝化工艺及钝化效果的检测方法。经过柠檬酸钝化液钝化处理后,可有效去除车体表面游离铁和其他杂质,车体表面颜色均匀一致,提高了不锈钢车体的耐蚀性和美观性。     

两种跨平台航迹精度测评方法研究

跨平台航迹精度测评对多平台协同使用传感器航迹数据具有指导意义,论文介绍了相对于本平台距离/方位的测评方法(方法一)和空间距离精度的测评方法(方法二),从非线性坐标变换的角度分析了本平台位置对测评结果的影响,其中方法一的计算结果在两平台位置相差不大的情况下主要受被探测目标相对于这两个平台的方位角度差影响,方法二的计算结果则不受本平台位置的影响,因而后者更有意义。     

Occupant injury risk analysis at NASS/CDS database

Injury information for vehicle occupants from the body regions of the head, thorax, abdomen, and upper and lower extremities, due to the restraints and interior parts of the vehicle, were extracted from the 2009 ~ 2012 NASS/CDS database. For those cases with high occurrence frequency, a detailed and comprehensive data analysis was performed to find the relationship between the accident, occupant, vehicle, and injury data. A numerical frontal impact sled model with the Hybrid III dummy and the GHBMC human body model was constructed to simulate and identify those injury risks according to NASS/CDS. Among the 5,734 injuries to the aforementioned body regions from frontal crashes are, listed by frequency of occurrence, the lower extremity (27.8 %), upper extremity (21.3 %), thorax (15.1 %), face (10.9 %), spine (8.7 %), head (7.3 %), and abdomen (6.9 %). The main injury sources to the head were the windshield, side structure, and steering wheel. For the thorax and abdomen they were the seat belt and steering wheel. For the lower extremity it was the instrument panel. The main injury patterns for the head were the concussion and the contusion. For the thorax they were vessel laceration and lung contusion. For the abdomen they were laceration and contusion of the organs. For the lower extremity they were bone fracture and ligament rupture. The steering wheel and seat positions were main factors affecting head and thorax injury risks. From the sled impact simulation, high injury risks of the head and thorax were assessed respectively at conditions of steering column tilt down and rear most seat position, which correlated well with the findings from the NASS/CDS data analysis.     

Integrated approach to an optimal automotive timing chain system design

Ensuring engine efficiency is a crucial issue for automotive manufacturers. Several manufacturers focus on reducing the time taken to develop and introduce brand new vehicles to the market. Thus, a synergic approach including various simulations is generally adopted to achieve a development schedule and to reduce the cost of physical tests. This study involved proposing a design process that is very useful in the preliminary development stage through effective support from simulations. This type of simulation-based design process is effective in developing timing chain drives; the use of this process, based on results from multiple trials, showed improvements in performance including low friction and vibration, improved durability, and cost-effective part design when compared to conventional processes. This study proposes an integrated approach to the preliminary design of an automotive timing chain system. The approach involves structural and dynamic analyses. The details of the design process are described by using the case of a virtual engine. This study conducted and summarized a dynamic and structural analysis as well as topological optimization to describe a process to obtain optimal results. The results of this study indicated the following improvements in overall performance factors: 12.1 % improvement in transmission error, 10.1 % reduction in chain tension, 46 % reduction in tensioner arm weight, and 11 % reduction in transversal displacement.     

掺锶磷酸钙骨水泥的体外细胞生物学性能评价及其与掺锶量的相关性

目的 评价"SrHPO4/Ca4(PO4)2O/CaHPO4"系掺锶磷灰石骨水泥的生物相容性及其与掺锶量的关系.方法 通过急性全身毒性、热原性、溶血性、体外细胞毒性以及成骨细胞在材料表面的黏附、增殖与表达等实验,检测材料的性能及生物降解潜能.结果 "SrHPO4/Ca4(PO4)2O/CaHPO4"系掺锶磷灰石骨水泥的急性全身毒性、热原性、溶血性、体外细胞毒性均为合格.Sr-CPC的热原性、溶血性以及碱性磷酸酶值与掺锶量呈非线性关系.结论 含锶磷酸钙骨水泥体外细胞生物相容性良好,是安全的新型骨组织工程支架材料.     

生存素在5-氟尿嘧啶诱导人绒癌细胞株JAR凋亡中的作用

目的探讨生存素(survivin)在化疗药物5-氟尿嘧啶(5-Fu)诱导的人绒癌细胞株(JAR)凋亡中的作用。方法用JAR细胞株进行培养传代,以不同浓度5-Fu作用于JAR细胞,MTT方法观察5-Fu对JAR细胞生长的抑制情况,流式细胞仪检测细胞凋亡率,用逆转录聚合酶链(RT-PCR)和免疫印迹技术(Western-blot)方法检测survivin基因和蛋白的表达。结果①5-Fu对JAR细胞的生长具有抑制作用,并有浓度和时间的依赖性;②5-Fu诱导JAR细胞凋亡,凋亡率随浓度而增加;③5-Fu作用后survivin基因和蛋白表达减少,随浓度增加而减少。结论5-Fu可能是通过降低survivin表达水平,诱导JAR细胞凋亡。     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

正常绒毛和葡萄胎中Mel-CAM标记中间型滋养细胞的增殖情况

目的探讨葡萄胎中Mel-CAM与滋养细胞黏附、浸润之间的关系以及Mel-CAM标记中间型滋养细胞(IT)的增殖情况。方法采用双重免疫组化法,检测Mel-CAM标记IT的Ki-67表达情况。结果葡萄胎中Mel-CAM表达较正常绒毛明显增高,差异有统计学意义(P<0.05);葡萄胎绒毛表面有Mel-CAM标记IT出现,而正常绒毛表面则无;葡萄胎组织中IT的Ki-67指数较正常绒毛明显增高,差异有统计学意义(P<0.05)。结论葡萄胎绒毛表面有Mel-CAM表达,表现出双重分化方向,这可能与葡萄胎的发病机制有关;检测葡萄胎组织中IT的Ki-67指数对于预测葡萄胎的转归有潜在的价值。     

南京长江隧道盾构始发井深基坑降水方案设计

南京长江隧道工程盾构始发井深大基坑地质条件复杂,地下水位高,并与长江水力联系密切,降水难度大.文章结合实践,重点阐述了本工程采用深井管井与轻型井点结合降水方案的设计,其中包括涌水量的计算、降水井数量的确定及降水井间距布设等参数研究,对今后同类工程的修建有一定的借鉴意义.