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Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM. 相似文献
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A new hierarchical approach called bintree energy segmentation was presented for color image segmentation. The image features are extracted by adaptive clustering on multi-channel data at each level and used as the criteria to dynamically select the best chromatic channel, where the segmentation is carried out. In this approach, an extended direct energy computation method based on the Chan-Vese model was proposed to segment the selected channel, and the segmentation outputs are then fused with other channels into new images, from which a new channel with better features is selected for the second round segmentation. This procedure is repeated until the preset condition is met. Finally, a binary segmentation tree is formed, in which each leaf represents a class of objects with a distinctive color. To facilitate the data organization, image background is employed in segmentation and channels fusion. The bintree energy segmentation exploits color information involved in all channels data and tries to optimize the global segmentation result by choosing the "best" channel for segmentation at each level. The experiments show that the method is effective in speed, accuracy and flexibility. 相似文献
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P物质和表皮生长因子受体在早期银屑病发病中的作用 总被引:1,自引:0,他引:1
目的 探讨P物质 (substanceP ,SP)和表皮生长因子受体 (epidermalgrowthfactorreceptor ,EGFR)在银屑病发病早期的作用机制。方法 用放射免疫法检测正常组织和各期银屑病皮损处SP和EGFR的表达状况。结果 进行期银屑病患者和静止期银屑病患者皮损处SP明显高于恢复期患者和正常人 (P <0 .0 5 )。进行期和静止期银屑病患者皮损表皮中EGFR阳性表达明显高于正常皮肤 (P <0 .0 5 ) ;恢复期皮损的阳性表达与正常组织无显著差异性 (P >0 .0 5 )。结论 SP和EGFR可能在银屑病发病的早期阶段相互协同而起关键作用 相似文献
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简述了主动磁轴承的工作原理及数学模型,在传统系统辨识的基础上提出了基于BP神经网络的非线性辨识方案.通过闭环控制使转子稳定悬浮,并在控制器的输出信号中加入随机噪声,以使系统被充分激励.按照10 kHz的采样频率对磁轴承的I/O数据进行采样,以用于磁轴承特性的辨识.对某单自由度磁轴承的仿真表明,神经网络模型能够以很高的精度逼近磁轴承的输入输出数据,且对不同的输入信号有较好的泛化能力,验证了所提方案的有效性. 相似文献
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对我国北方地区最大的公路病害——道路冻胀翻浆的成因、危害程度均作了详细的论述。并从理论上和设计、施工方面提出了切实可行的防治措施,对公路工程的设计、施工具有广泛的指导意义和实用性。 相似文献
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In this paper, we investigate the outage performance of a dual-hop amplify-and-forward(AF) multipleinput multiple-output(MIMO) relay network, considering beamforming transmission with outdated channel state information(CSI) and an arbitrary number of co-channel interferers at both the relay and the destination. The exact closed-form expression for the outage probability is derived, and the asymptotic behavior of the outage probability is also presented to provide further insights into the system performance. Our results show that the system suffers a diversity gain loss caused by the outdated CSI, and the interference only degrade the coding gain of the system. Moreover, increasing antennas can achieve more performance gains, however, the gains decrease as the delay of the CSI increases. 相似文献
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PTEN和PCNA在子宫内膜癌组织中的表达 总被引:2,自引:0,他引:2
目的探讨抑癌基因PTEN及增殖细胞核抗原(PCNA)在子宫内膜癌中的表达及临床意义。方法应用免疫组化SP法检测PTEN和PCNA在18例正常增生期子宫内膜(正常组)、21例子宫内膜不典型增生(癌前病变组)和22例子宫内膜腺癌(内膜癌组)中的表达。结果正常组、癌前病变组及内膜癌组PCNA表达分别为61.1%(11/18)、71.4%(15/21)和95.5%(21/22),3组间比较,差异有统计学意义(P<0.05);各组子宫内膜组织中PTEN表达分别为:正常组88.9%(16/18)、癌前病变组71.4%(15/21)、内膜癌组27.3%(6/22),3组间比较,差异有统计学意义(P<0.05)。结论PCNA表达增强可能是子宫内膜癌在分子水平上的早期变化,PTEN表达减弱可能与子宫内膜腺癌的发生、发展密切相关,二者对早期诊断子宫内膜癌有一定意义。 相似文献
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着眼于如何采用预防性养护改进路面管理系统,使路面管理系统支持预防性养护计划的制定;提出整合的方法,分析每一种方法的优缺点,讨论整合的必要性以及在整合过程中可能遇到的问题,最后为如何有效的把预防性养护整合到路面管理系统中提供了一些技术措施。 相似文献