丹参对恶性梗阻性黄疸治疗作用的实验研究

目的研究丹参对实验性梗阻性黄疸型肝癌发展的影响。方法SD大鼠肝门部肝实质种植Walker-256癌株瘤块,建立恶性梗阻性黄疸模型。将模型鼠分成4组:生理盐水组(n=24)、肌苷+VC组(n=40)、丹参组(n=40)及5-FU组(n=40)。通过腹腔内分别注射生理盐水、肌苷+VC、丹参及5-FU,观察肝功、肝组织形态学及肝癌、癌周、临近肝叶及肺组织中增殖细胞核抗原(PCNA)、血管内皮生长因子(VEGF)及细胞间黏附分子-1(ICAM-1)的表达情况。结果①丹参组对肝功的保护作用明显优于生理盐水组和5-FU组(P<0.01),而与肌苷+VC组相比无显著性差异(P>0.05);同时丹参组对梗阻性黄疸所致的组织形态学损害产生保护作用。②丹参组抑癌率和抑转移率均明显高于生理盐水组和肌苷+VC组(P<0.01);而与5-FU组相比无显著性差异(P>0.05)。③丹参组肝癌、癌周、临近肝组织及肺组织中PCNA、VEGF、ICAM-1的表达均低于肌苷+VC组和生理盐水组(P<0.01);与5-FU组比较,PCNA和VEGF无显著性差异(P>0.05),而ICAM-1则有显著性差异(P<0.05)。结论丹参对恶性梗阻性黄疸的肝脏损害有保护作用,而且通过抑制肝癌细胞增殖、阻碍肿瘤血管的形成及防止肝内外转移等机制而表现出抗癌作用。     

Improved Parallel Three-List Algorithm for the Knapsack Problem without Memory Conflicts

Based on the two-list algorithm and the parallel three-list algorithm, an improved parallel three-list algorithm for knapsack problem is proposed, in which the method of divide and conquer, and parallel merging without memory conflicts are adopted. To find a solution for the n-element knapsack problem, the proposed algorithm needs O（2^3n/8） time when O（2^3n/8） shared memory units and O（2^n/4） processors are available. The comparisons between the proposed algorithm and 10 existing algorithms show that the improved parallel three-fist algorithm is the first exclusive-read exclusive-write （EREW） parallel algorithm that can solve the knapsack instances in less than O（2^n/2） time when the available hardware resource is smaller than O（2^n/2） , and hence is an improved result over the past researches.     

液基细胞学和传统涂片法在痰液标本诊断肺癌中的价值比较

目的评价液基细胞学在痰液标本中的应用价值。方法对临床送检的287例痰液标本行液基细胞学方法处理,并与传统涂片方法进行比较分析。结果液基细胞学和传统涂片法检出肺癌的灵敏度分别为21.6%(62/287)和17.1%(49/287),两者相比差异无统计学意义;但两种方法联用灵敏度可达24.0%,与传统涂片法相比差异有统计学意义(P<0.05),而与液基细胞学方法比较差异不显著。液基细胞学和传统涂片法诊断肺癌的假阴性率分别为38.6%和48.5%,两者相比差异无统计学意义;但两种方法联用假阴性率为31.7%,与传统涂片法相比差异有统计学意义(P<0.05),而与液基细胞学方法比较差异不显著。结论通过痰液标本检测肺癌细胞,液基细胞学要好于传统涂片法,具有明显的优越性;两者联用可提高肺癌的检出率,值得临床大力推广。     

Effect of temperature- and frequency-dependent dynamic properties of rail pads on high-speed vehicle–track coupled vibrations

The soft under baseplate pad of WJ-8 rail fastener frequently used in China’s high-speed railways was taken as the study subject, and a laboratory test was performed to measure its temperature and frequency-dependent dynamic performance at 0.3?Hz and at ?60°C to 20°C with intervals of 2.5°C. Its higher frequency-dependent results at different temperatures were then further predicted based on the time–temperature superposition (TTS) and Williams–Landel–Ferry (WLF) formula. The fractional derivative Kelvin–Voigt (FDKV) model was used to represent the temperature- and frequency-dependent dynamic properties of the tested rail pad. By means of the FDKV model for rail pads and vehicle–track coupled dynamic theory, high-speed vehicle–track coupled vibrations due to temperature- and frequency-dependent dynamic properties of rail pads was investigated. Finally, further combining with the measured frequency-dependent dynamic performance of vehicle’s rubber primary suspension, the high-speed vehicle–track coupled vibration responses were discussed. It is found that the storage stiffness and loss factor of the tested rail pad are sensitive to low temperatures or high frequencies. The proposed FDKV model for the frequency-dependent storage stiffness and loss factors of the tested rail pad can basically meet the fitting precision, especially at ordinary temperatures. The numerical simulation results indicate that the vertical vibration levels of high-speed vehicle–track coupled systems calculated with the FDKV model for rail pads in time domain are higher than those calculated with the ordinary Kelvin–Voigt (KV) model for rail pads. Additionally, the temperature- and frequency-dependent dynamic properties of the tested rail pads would alter the vertical vibration acceleration levels (VALs) of the car body and bogie in 1/3 octave frequencies above 31.5?Hz, especially enlarge the vertical VALs of the wheel set and rail in 1/3 octave frequencies of 31.5–100?Hz and above 315?Hz, which are the dominant frequencies of ground vibration acceleration and rolling noise (or bridge noise) caused by high-speed railways respectively. Since the fractional derivative value of the adopted rubber primary suspension, unlike the tested rail pad, is very close to 1, its frequency-dependent dynamic performance has little effect on high-speed vehicle–track coupled vibration responses.     

基于海明距离-TOPSIS法的山区公路隧道扩建方案直觉模糊优选

为了解决山区高速公路隧道改扩建方案选取决策困难而又缺乏理论依据的问题,基于直觉模糊数的海明距离,结合TOPSIS方法,增加专家权向量修正,进而得到处理具有优先级别关系的多属性问题的决策方法。分析山区高速公路隧道改扩建的影响因素,建立隧道扩建方案影响指标体系。从依托工程实际出发,邀请指定的专家对指标优先级别排序,然后利用已建的数学模型实现扩建方案寻优。该方法在厦蓉高速公路隧道改扩建施工方案优选中得到有效运用,说明该方法实用可行,对隧道改扩建施工方案以及类似工程方案优选问题具有重要的指导意义。     

《心住南海》英文节选(续)(英文)

(continued from last issue)Today’s Xi Sha On July 17,2012,the Sansha City People’s Congress preparation committee was set up.The city would cover an island area of 13 square k ilometers and sea area of over 2 million square kilometers.A week later,Sansha formally became a city of Hainan Province.The Xinhua News Agency reported:"The setup of Sanshaas a prefectural level cityis an adjustment and improvement to our administrative system in our Xi Sha,Zhong Sha and Nan Sha Islands and     

高桩承台桩基计算

根据现行规范及桩基计算理论,编写了计算程序,通过算例分析比较,程序计算结果比较精确,可以使用程序方便地计算高桩承台桩基的位移以及内力,从而为工程设计提供依据。     

城市轨道交通综合监控系统的辅助决策支持系统

辅助决策系统是轨道交通综合监控系统的高级应用模块。辅助决策系统充分利用综合监控系统的数据集中优势,把人的判断力和计算机的信息处理能力综合在一起,提高地铁操作人员与维护人员的决策效能而又不影响他们的主观能动性。     

地铁数据通信系统三种主要无线通信制式的比较

介绍了目前国内城市轨道交通基于通信的列车控制系统中数据通信所采用的无线子系统的三种制式,对这三种制式的特点分别作了描述,着重介绍了TD-LTE(时分-长期演进)制式的一些特点。对这三种主要的无线通信制式,从频率资源、抗干扰性、产品成熟度、自主化程度、成本、数据速率和设备安装等方面进行了对比。     

无核密度仪(PQI)在道路工程领域的应用现状

文中利用无核密度仪(PQI)检验温度离析对沥青面层压实质量,采用无核密度仪(PQI)快速无损地定量检测沥青混凝土路面的密度变化情况,对施工质量进行动态控制和评估,分析了沥青混凝土路面在横向和纵向的非均匀性及其原因。同时,研究了温度对沥青混凝土路面均匀性的影响,结果表明温度只要在压实温度以上,对非均匀性的影响并不明显。