Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

某高速公路桥梁拓宽后伸缩缝锚固区混凝土破坏原因分析

结合九乡河大桥扩建工程,探讨了桥台处伸缩缝锚固区混凝土的有限元建模方法,着重研究了桥台处伸缩缝锚固区混凝土的破坏成因。分析表明,伸缩缝锚固区开裂的主要原因是新旧桥台的不均匀沉降,采用文中提供的建模方法,可以正确地模拟伸缩缝处混凝土的破坏,从而明确破坏机理,并为此类旧桥加宽工程的设计和施工提供借鉴。     

论稀浆封层、改性稀浆封层、微表处之异同

随着我国大量高速公路进入维修养护期,稀浆封层、改性稀浆封层、微表处等路面预防性养护技术受到了前所未有的关注。从定义、技术要求、应用范围等多方面出发,分析这三项预防性养护技术的异同,有助于公路工程者以科学的态、度,从实际情况出发,因地制宜,进行严格的甄选。     

Simulation and analysis of vehicle stability based on ADAMS/CAR differential brake

To improve the braking safety of automobiles, the author studied the effect of differential brake on the stabilities. To analyze the mechanical characteristics of differential brake, automotive subsystem models were built by applying ADAMS/CAR, and automotive mechanics simulation model was built by setting the main subsystems such as body, engine and brake. The simulation model studied the distribution mode of three kinds of differential brake, and beeline braking stability and turning braking stability were simulated. It shows that differential brake can amend turning shortage of automobile brake and improve its braking stability, but the effect of automobile mass on its braking stability is great. So the distribution mode of braking force and the effect of mass change should be considered while differential brake is applied.     

智能交通系统中信息情报板优化设计

信息情报板是智能交通系统中信息发布的主要手段之一,对其进行合理的结构设计,是保证信息发布效果的重要技术措施。在分析驾驶员从发现信息板到采取行动的全过程的基础上,提出的一种信息情报板结构优化模型．可用于信息情报板结构优化的实践当中。     

船舶在港时间及其管理与控制

船舶在港时间有较强的可压缩性,协调好船方、货主、码头作业和相关部门及单位的工作,是提高船舶在港作业效率,节省船舶在港时间的重要途径．     

集料含水率对混凝土配合比的影响

集料含水率对于混凝土水胶比波动有十分重要的影响,砂石料中水含量变化将会影响设计配合比在施工中的实现。文章对苏通大桥集料的含水率进行测定,研究典型天气条件下含水量分布和变化情况,提出调整不同天气条件下砂石料含水率方法。     

关兴公路蛇形坡隧道衬砌渗漏水的综合治理

衬砌渗漏水是公路隧道常见的病害之一。通常方法仅针对渗漏部位进行处理,导致病害未能得到彻底治理,病害容易再次发生。以贵州省关兴公路蛇形坡隧道衬砌渗漏水病害整治工程为例,从“防、排、截、堵”出发,采用了5种措施对渗漏缝（点）进行修复,同时进行衬砌背后注浆堵水,在两侧施作排水降压孔以降低衬砌背后地下水压力,清理改造隧道排水沟,对衬砌渗漏水进行综合治理,以达到彻底整治的目的。     

55岁以上自然人群中帕金森病患者认知功能障碍的临床研究

目的　了解 55岁以上自然人群中帕金森病 (Parkinson sdisease ,PD)患者认知功能障碍的发生情况。方法　以流行病学调查资料为基础 ,采用非配对的病例对照研究方法 ,分析 55岁以上自然人群中PD患者认知功能障碍的发生率 ,评估认知功能障碍发生的相对危险性。结果　 55岁以上自然人群中 ,PD组和非帕金森病 (noParkinson sdis ease,NOPD)组认知功能障碍的发生率分别为 2 7.78%、5.55% ;年龄调整的发生率分别为 16.2 0 %、9.87%。与同一自然人群中NOPD组比较 ,PD组发生认知功能障碍的危险性明显增高 ,但主要增加低年龄组 (55～ 74岁 )中老年人发生认知功能障碍的危险性 (OR =8.59,95%CI :3 .13～ 2 3 .80 ) ;而且PD是低年龄中老年人发生认知功能障碍和痴呆的独立危险因素 (OR =6.2 7,95%CI :2 .3 5～ 19.2 7;OR =5.50 ,95%CI :1.52～ 19.94)。年龄调整的MMSE分值的均值PD组明显低于NOPD组 (P <0 .0 0 1)。结论　PD主要增加低年龄 (55～ 74岁 )中老年人认知功能障碍发生的危险性 ,而且PD认知功能障碍是疾病本身所致     

白细胞介素-12对哮喘患者Th细胞的作用

目的　观察白细胞介素 12 (IL 12 )对哮喘患者辅助性T淋巴细胞 (Th)的分化和细胞因子分泌的影响 ,探讨IL 12对哮喘治疗的机制及应用。方法　从哮喘患者外周血分离出单核细胞和CD4 + T(Th)细胞 ,单核细胞被尘螨变应原刺激活化后同CD4 + T细胞分别与 1μg·L-1和 5 μg·L-1IL 12共培养 ,对照组不加IL 12。 72h后收集培养上清 ,ELISA法检测IL 4、IL 5和IFN γ的生成量。培养细胞用荧光标记的单克隆抗体染色 ,流式细胞仪 (FCM)检测细胞内特异性细胞因子。结果　与对照组相比 ,实验组IL 4、IL 5的产生量明显减少 ,IFN γ的产生量显著增加 (P <0 .0 1) ,而且这种变化趋势在 1μg·L-1、5 μg·L-1IL 12间也有统计学差异 (P <0 .0 5 )。实验组Th1/Th2向Th1方向漂移 ,Th1/Th2增加 (P<0 .0 1)。结论　IL 12可调节Th的分化方向及不同类型细胞因子的分泌 ,并在一定浓度范围内呈量效依赖性。提示IL 12可作为一种新的哮喘治疗途径