盾构隧道整体道床剥离病害规律研究北大核心CSCD

盾构隧道整体道床的剥离病害已严重影响地铁的安全运营。为研究整体道床剥离病害的规律,文章以国内某运营地铁线路为工程背景,建立整体道床-管片-注浆层数值模型进行分析研究。结果表明:列车轮组作用在道床一侧靠近伸缩缝位置时会引起较大的道床剥离变形,是最不利位置;列车荷载在振动作用下引起的剥离量远大于静载作用时的,且两者间存在函数关系;伸缩缝位置是最易发生剥离的区域,剥离首先发生在伸缩缝两侧边缘,随列车动载作用时间增加,剥离区域扩展至伸缩缝1.5 m范围内;注浆层刚度与接触面黏结强度均是影响剥离量的重要因素,提升注浆层刚度和道床-管片接触面的黏结强度可有效减少剥离量。     

An application of a rank ordered probit modeling approach to understanding level of interest in autonomous vehicles

Surveys of behavior could benefit from information about people’s relative ranking of choice alternatives. Rank ordered data are often collected in stated preference surveys where respondents are asked to rank hypothetical alternatives (rather than choose a single alternative) to better understand their relative preferences. Despite the widespread interest in collecting data on and modeling people’s preferences for choice alternatives, rank-ordered data are rarely collected in travel surveys and very little progress has been made in the ability to rigorously model such data and obtain reliable parameter estimates. This paper presents a rank ordered probit modeling approach that overcomes limitations associated with prior approaches in analyzing rank ordered data. The efficacy of the rank ordered probit modeling methodology is demonstrated through an application of the model to understand preferences for alternative configurations of autonomous vehicles (AV) using the 2015 Puget Sound Regional Travel Study survey data set. The methodology offers behaviorally intuitive model results with a variety of socio-economic and demographic characteristics, including age, gender, household income, education, employment and household structure, significantly influencing preference for alternative configurations of AV adoption, ownership, and shared usage. The ability to estimate rank ordered probit models offers a pathway for better utilizing rank ordered data to understand preferences and recognize that choices may not be absolute in many instances.     

越南某电厂新建煤码头排水系统设计方案优化

越南某燃煤电厂为满足当地电力的发展需求,拟对电厂进行扩建,并新建煤码头及输煤系统。针对外方提供的新建煤码头排水系统设计方案,从技术和经济角度展开全面分析,指出外方设计的排水系统存在的不足。结合国内煤码头排水系统的习惯做法,通过对比分析,对外方设计的排水系统进行优化,以满足码头区域雨水和冲洗废水“零排放”的环保要求。     

轮轨噪声的产生机理及其治理措施

根据国外对轮轨噪声机理研究和实验成果及技术应用实例,分别从轮轨粗糙度激励、车轮振动、钢轨振动、轨枕振动和声辐射等五个主要方面对轮轨噪声的产生机理进行分析和讨论,注重研究轨道交通的噪声源———轮轨噪声,找到轮轨噪声的产生根源,为轮轨噪声的治理提供可靠的理论依据,然后以此机理为着眼点,再结合国外对机理的研究和试验成果及其技术和产品的应用实践,分别从以上提到的轮轨噪声产生机理的五个主要方面,并结合我国轨道交通轮轨噪声的实际情况,提出控制轮轨噪声的治理措施,为我国城市轨道交通轮轨噪声治理提出参考性建议。     

褪黑素对低硒饲料大鼠肝脏损伤的影响

目的　研究褪黑素对克山病病区低硒粮喂养的大鼠肝脏损伤的影响及其可能机制。方法　将SD大鼠分为3组 ,分别用低硒饲料、低硒饲料加硒、低硒饲料加褪黑素灌胃饲养 ,观察大鼠体质量增加情况。 12周时检测血Se、血GSH Px活性、肝组织MDA水平及肝组织病理损伤情况。结果　 12周时低硒组大鼠的体质量增加明显低于其他两组 ,血Se、血GSH Px活性较加硒组 (对照组 )显著降低 ,肝组织MDA及光镜下肝脏病变检出率均明显高于其他两组。加硒组与褪黑素组MDA无显著差异 ,光镜下两组均未见肝坏死。结论　褪黑素可预防克山病病区低硒粮引起的大鼠肝脏损伤 ,其保护作用可能与抗氧化机制有关。     

先天性长QT综合征相关人类HERG基因真核表达载体的构建及其功能表达

目的构建先天性长QT综合征相关HERG基因的真核表达载体,观察其在真核细胞中的表达,建立稳定的细胞系,探讨基因的功能。方法原核克隆载体pGEM-HERG经限制性内切酶获得HERG cDNA,将HERG cDNA亚克隆到真核表达载体pcDNA3中,用Lipofectamin2000转染试剂介导将pcDNA3-HERG及荧光真核表达载体pRK5-GFP共转染至HEK-293细胞,利用G-418进行细胞筛选,并用稀释法建立稳定的HEK-HERG细胞系。用全细胞膜片钳技术检测HERG基因的功能表达情况。结果在原核克隆载体pGEM-HERG的基础上构建了HERG的真核表达载体pcDNA3-HERG,并使其在HEK-293细胞中成功表达,建立的HEK-HERG细胞系稳定传代。膜片钳技术检测到了HERG通道电流的表达。结论该方法可成功构建及表达HERG的真核表达载体,为今后突变型HERG的研究奠定了基础。     

蜂群优化算法在轨道交通线网物资总库合理布局中的应用

建立了轨道交通物资总库布局的数学模型,运用蜂群优化算法同时解决了物资总库数目和位置的确定两个问题。在蜂群优化算法迭代的过程中,设计了独特的编码方法和交叉算子,并结合问题特征给出了局部搜索算法,有效地进行解空间的搜索,从而求得全局最优解。     

我国城市地下空间运营管理问题的分析与探讨

分析了城市地下空间运营管理的模式,并对影响模式选择的因素进行了探讨.指出我国现有政策环境不能满足地下空间运营管理发展的需要.地下空间运营管理的法律法规不健全,缺乏有效的约束监管机制,运营管理机制落后等是我国城市地下空间运营管理存在的主要问题.针对以上的问题,提出了城市地下空间运营管理的政策建议:应确立地下空间运营管理的正确指导思想和基本原则;健全地下空间运营的法律、法规保障体系;强化政府的宏观调控、弱化微观市场干预;树立以人为本的运营管理模式;理顺政府部门职能关系、构建统一的运营管理体制;消除行业壁垒、打造统一的地下设施体系;建立与完善地下养护体系,实行建设、养护一体化管理;开辟绿色通道,实现安全管理优先;加强政府对地下空间的运营监管等.     

EXPRESSION OF MATRIX METALLOPROTEINASE-2 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN HUMAN GLIOMA AND THEIR RELATION TO THE INVASION OF THE TUMOR

Neovascularizationcanbeobservedinthe courseoftumorformationandmalignantinvasion,whichwillpromotethemalignantinvasionofthe tumor[1].Vascularendothelialgrowthfactor(VEGF)andmatrixmetalloproteinases(MMPs)are theimportantadjustiveproteinsintheinvasionand neov…     

Galvanic corrosion behaviour of HE 20 / MDN 138 & HE 20 / MDN 250 alloys in natural seawater

In view of their excellent mechanical properties, workability and heat treatment characteristics, MDN 138 & MDN 250 have been widely used in missile, rocket and aerospace industries. With light weight and high performance characteristics HE 20 aluminium alloy acts as an important material in defence and aerospace applications. The galvanic corrosion behaviour of the metal combinations HE 20 / MDN 138 and HE 20 / MDN 250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI’s Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN 138, MDN 250 and HE 20 of the individual metal, the mixed potential and galvanic current of the couples HE 20 / MDN 138 and HE 20 / MDN 250 were periodically monitored throughout the study period. The calcareous deposits on MDN 138 and MDN 250 were analysed using XRD. The results of the study reveal that that HE 20 has offered required amount of protection to MDN 138 & MDN 250.