LIGUSTRAZINE REDUCES CARTILAGE DESTRUCTION IN MODEL OF OSTEOARTHRITIS IN RATS

Objective To study the effect and possible mechanism of Ligustrazine-a chinese traditional herbal medicine (CTM) on rat osteoarthritis (OA). Methods OA model was surgically induced. Morphology of articular cartilage was done by HE staining and mankin score was calculated; interleukin-1 and TNFα activity of rat joints was determined by 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method; immunohistochemistry of MMP-13 and Cathepsin K was done by ABC method while the mRNA level for MMP-13, cathepsin K and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) was evaluated by RT-PCR method. ResultsLigustrazine (60 mg·kg-1·d-1 or 30 mg·kg-1·d-1, but not 10 mg·kg-1·d-1, im, ×8 weeks) reduced morphological changes of articular cartilage of OA rats. IL-1 and TNFα production of OA joints increases, together with MMP-13, cathepsine K and their mRNA levels in articular cartilage. The administration of Ligustrazine (60 mg·kg-1·d-1or 30 mg·kg-1·d-1, im, ×8 weeks) reduced above changes significantly. At the same time, tissue inhibitor of metrix metalloprotease (TIMP1) mRNA level increased also in OA rats while Ligustrazine (60 mg·kg-1·d-1, 30 mg·kg-1·d-1or 10 mg·kg-1·d-1, im, ×8 weeks) had no significant effect on it. Conclusion Ligustrazine (60 mg.kg-1 d-1 or 30 mg·kg-1·d-1, but not 10 mg·kg-1·d-1, im, ×8 weeks) effectively delays articular cartilage degradation of OA rats and could be a potential drug candidate for OA treatment.     

Study on Real-time Look-ahead and Adaptive Parametric Curve Interpolator

The principle of real-time look-ahead was introduced and analysed. An adaptive parametric curve interpolator with a real-time look-ahead function was developed for non-uniform rational B-spline (NURBS) curves interpolation, which considering the maximum acceleration/deceleration of the machine tool. In order to deal with the acceleration/deceleration around the feedrate sensitive corners, the look-ahead function was designed and illustrated. It can detect and adjust the feedrate adaptively. With the help of real-time look-ahead, the acceleration/deceleration can be limited to the range of the machine tool capacity. Thus, feedrate fluctuation is reduced. A NURBS curve interpolation experiment was provided to verify the feasibility and advantages of the proposed interpolator with a real-time look-ahead function.     

Study and Development of the Biped Ice Skating Robot with Passive Wheels

A new passive wheel type of biped ice-skating robot(BISR)which was able to imitate human skating motion was developed. Firstly, the characteristics of two types of human skating gait were introduced; secondly, after simplifying the kinematical model, the BISR's motion principle was presented; then the construction and control system of BISR were proposed; at last, the skating experiment of the BISR in a symmetric gait mode was conducted and some conclusions were drawn.     

苏通大桥承台封底混凝土与钢护筒间握裹力的试验研究与应用

通过对苏通大桥承台封底混凝土与钢护筒间握裹力的试验研究与施工现场检测,提出钢护筒与承台封底混凝土间的握裹力系数.     

AT1000A型沥青混合料转运车的应用

为了提高沥青路面施工质量,广东省长大公路工程有限公司在广东省范围内率先引进了AT1000A型沥青混合料转运车。主要介绍该公司在广东河源—龙川高速公路施工中采用的AT1000A型沥青混合料转运车、新的转运-摊铺施工工艺及使用效果。     

SMA混合料在桥面铺装施工中的质量控制要点

通过SMA混合料在桥面铺装中的应用,介绍SMA混合料的特点、配合比设计及生产控制,阐述SMA混合料桥面铺装施工工艺与路面性能指标的关系。     

基于交通效率、安全和特定交通组成的纵坡合理坡长

由于用地及地形、地质等限制,纵坡常被迫用到规范推荐的限制值,而我国《城市道路设计规范》(CJJ37-90)对5%以下的纵坡坡长限制没有进行规定,如何确定此类纵坡的合理坡长直接影响到路段交通安全、效率、工程经济等。通过对已有的纵坡坡长限制研究成果整理分析,提出运用汽车动力学进行坡长计算时,应该考虑汽车坡中换档的情况,并引入适合车型的概念,建议根据道路交通组成的实际情况确定坡长。分析坡长对驾驶员心率增长率、制动鼓温度、事故率的影响,分别确定各影响因素下的最大坡长。最后提出综合考虑交通效率和安全的坡长限制确定方法,并在某大纵坡路段的纵坡论证中进行了应用。     

分离式立交地面层交叉口一体化设计方法研究

分离式立交是解决城市拥堵的有效手段,但立交桥地面层的平面交叉口设计仍缺乏足够重视,现有的组织方式、控制方案无法有效应对立交桥下特有的交通环境.文中分析立交地面层交叉口特有的交通环境,提出一体化组织方法及信号控制模型,运用VISSIM仿真软件分析评价一体化组织方法的适用范围,为实践中可否采用一体化组织方法的决策提供参考....     

温度及收缩荷载下路基上双块式无砟轨道力学及裂缝特性研究

温度及收缩荷载是双块式无砟轨道的重要荷载.以路基上双块式无砟轨道为研究对象,道床板中钢筋用梁单元模拟,道床板、双块式轨枕、支承层以实体单元模拟,道床板混凝土与钢筋、支承层与路基之间的连接用弹簧单元模拟,建立了考虑混凝土开裂的钢筋与混凝土相互作用有限元力学模型,并编制了相应的计算程序.研究了温度及收缩荷载下路基上双块式无...     

基于B/S的车辆管理信息系统的设计与实现

在对某供电公司车辆的运行现状分析的基础上,提出利用现在大多数公司都已经建立起来的局域网建立基于B/S模式的车辆管理系统的方案,有效地解决人工管理或半自动化管理带来的效率低下和准确性不够等问题.