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Thesequenceofeventsthroughwhichischaemialeadstocelldeathispoorlyunderstood.Anumberofendogenouscomponentshavebeenimplicatedinthesubsequentneurodegenerativeprocess,suchasglutamate,freeradicals,calciumandpolyamines,allofwhichhavebeenshowedtobeelevatedinassociationwithischaemicinsults.Agentssuchasglutamineandcalciumhaveestablishedrapidandpotentphysiologicalactions,thatareexaggeratedduringischaemia,leadingtoamassiveanduncontrolledamplificationoftheirnormaleffects.Animportantcomponentofthephysiologi… 相似文献
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