CB和MMP-9在上皮性卵巢肿瘤中的表达及相关性研究

目的检测组织蛋白酶B(cathepsin B,CB)与基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)在人类上皮性卵巢肿瘤中的表达,探讨两者与卵巢癌细胞的分化增殖、侵袭转移的关系。方法采用链霉素亲和生物素-过氧化物酶法(SP)进行免疫组织化学染色,用CB抗体、MMP-9抗体标记上皮性卵巢肿瘤组织标本,综合染色强度和阳性细胞占总体细胞数的百分比进行染色判定,结合有关病理特征进行分析。结果经统计学分析,CB、MMP-9在上皮性卵巢癌中的表达与年龄、病理类型无相关性(P>0.05),而与卵巢癌的临床分期、有无转移及腹水呈正相关(P<0.05);CB与卵巢癌的组织学分级呈正相关(P<0.05);上皮性卵巢癌中CB和MMP-9表达呈正相关(r=0.652,P<0.05)。结论CB、MMP-9与卵巢癌的恶性生物学行为密切相关,两者在其侵袭转移过程中发挥了重要的协同作用。     

自硬树脂砂ZH25叶片式振动混砂机的设计

本文对自硬树脂砂叶片式振动混砂机进行了详细的理论计算,并通过公式推导确定了振动混砂机的极限振次.制造的样机基本达到设计要求,且已通过鉴定.     

Classification decision tree algorithm assisting in diagnosing solitary pulmonary nodule by SPECT/CT fusion imaging

Objective To develop a classification tree algorithm to improve diagnostic performances of 99mTc-MIBI SPECT/CT fusion imaging in differentiating solitary pulmonary nodules (SPNs). Methods Forty-four SPNs, including 30 malignant cases and 14 benign ones that were eventually pathologically identified, were included in this prospective study. All patients received 99Tcm-MIBI SPECT/CT scanning at an early stage and a delayed stage before operation. Thirty predictor variables, including 11 clinical variables, 4 variables of emission and 15 variables of transmission information from SPECT/CT scanning, were analyzed independently by the classification tree algorithm and radiological residents. Diagnostic rules were demonstrated in tree-topology, and diagnostic performances were compared with Area under Curve (AUC) of Receiver Operating Characteristic Curve (ROC). Results A classification decision tree with lowest relative cost of 0.340 was developed for 99Tcm-MIBI SPECT/CT scanning in which the value of Target/Normal region of 99Tcm-MIBI uptake in the delayed stage and in the early stage, age, cough and specula sign were five most important contributors. The sensitivity and specificity were 93.33% and 78. 57e, respectively, a little higher than those of the expert. The sensitivity and specificity by residents of Grade one were 76.67% and 28.57%, respectively, and AUC of CART and expert was 0.886±0.055 and 0.829±0.062, respectively, and the corresponding AUC of residents was 0.566±0.092. Comparisons of AUCs suggest that performance of CART was similar to that of expert (P=0.204), but greater than that of residents (P<0.001). Conclusion Our data mining technique using classification decision tree has a much higher accuracy than residents. It suggests that the application of this algorithm will significantly improve the diagnostic performance of residents.     

舰船大容量变压器励磁涌流的故障识别

舰船电力系统已经逐步由传统的低压电力系统过渡到中压电力系统,变压器在舰船电力系统中地位和作用也日益凸现,对变压器的保护也日益重要,尤其是在发生短路故障时,迅速可靠的跳闸,是保证变压器安全的重要手段。大容量变压器的内部短路故障主要依靠差动保护,而励磁涌流往往会引起差动保护误动作,因此如何快速识别励磁涌流是确保变压器安全可靠的前提条件。     

透过港口看经济

港口是经济运行的"晴雨表",它们完成了全国近七成的外贸出口量,上下游有数以千万计的外贸企业和市场,透过它们,触摸经济脉搏。港口是经济运行的"晴雨表",记者近日走访上海港、宁波港、苏州港、广州港、连云港港等五大港口,透过这些"窗口",触摸经济脉搏。港口:"以前是船等码头,眼下是码头等船"苏州港地处长江入海口咽喉地带,以3.8亿吨的年货     

我国会计电算化的现状及对策

进入21世纪以来,随着经济全球化趋势的不断发展,我国经济发展日新月异,会计电算化已经成为企业经济管理系统的重要组成部分,在国民经济各个部门的应用日益普及。但在我国会计电算化高速发展的同时,也不可避免地出现了一些问题,本文就我国目前会计电算化发展的现状作出分析,并就这些问题提出切实可行的对策。     

热水夹套的配管设计与管件选用原则

化工装置中,对于黏稠和对热敏感的工艺介质选用热水夹套进行加热能达到良好的伴热效果.鉴于热水夹套管在设计和施工过程中的复杂性,夹套管在配管设计中要注意内外管尺寸选用、供热长度、柔性设计等设计原则,要保证热水的流动畅通,还要注意材质的选择.设计过程中,还应遵循弯头、三通、异径管、法兰、阀门、导向板、隔断板等管件的选用原则....     

海洋平台栈桥管道应力分析的模拟方法

栈桥是连接海上油气田两个或多个平台间油气水管线、电控线缆和人员通行的通道.平台间在风、波浪、船舶靠泊等荷载作用下会发生相对运动,通过栈桥的管道会承受平台间相对运动产生的位移荷载,管道应力水平是否满足规范要求在应力分析中需要重点考虑.应用CAESAR II软件,结合旅大27-2/32-2油田开发项目栈桥管道柔性计算实例,介绍了栈桥管道应力分析的模拟方法,并根据计算结果对管道布置提出建议和进行优化,为以后栈桥管道的设计提供计算方法和参考.     

汽车三轴转动惯量测量装置的设计

根据弹簧共振的原理设计了一套汽车三轴转动惯量的测量装置,该装置原理简单,结构紧凑,设计合理,可满足绝大多数类型轿车的三轴转动惯量测量要求。     

福特蒙迪欧车加速不良且排气管发红

故障现象一辆2006款长安福特蒙迪欧轿车,搭载2.5 L Duratec-VE V6发动机,行驶里程约为28万km,该车因加速不良而进厂维修。故障诊断接车后试车确认故障,发现故障确实存在。对车辆进行常规检查,并没有发现问题,接着又测量了燃油泵的供油压力,为380 kPa,在正常范围内。连接故障检测仪读取故障代码,没有故障代码存储。此后又更换了汽油滤清器、火花塞、点火线圈和分缸线并清洗喷油器及发动机内部积炭等,故障依然存在。后与同型号车辆对换动力控制模块(PCM)并解除被动防盗后试车,故障依旧。故障排除陷入僵局,于是找到笔者共同探讨此故障。