海底隧道全强风化花岗岩地层注浆技术研究

厦门翔安海底隧道施工中面临着穿越浅滩全风化岩层、沙砾层透水胶结带和海底全强风化深槽等3大控制性工程难点,为此由建设、设计、研究、施工等各方立项进行了前期可行性研究.文章对注浆工艺、注浆材料、注浆参数等进行了专题研究.并结合服务隧道工程的注浆试验实施,提出了在全强风化花岗岩地层中注浆加固的可行性及其相应的注浆方案、工艺、参数和设备的确定.     

《发动机系统检修》课程改革的思考与实践

随着互联网时代及各种信息移动终端的普及,《发动机系统检修》教学迎来了新的机遇和挑战,对于该课程的教学教学方式和内容进行改革十分必要。文章着重分析了传统的汽车发动机系统维修课程教学中存在的不足,以及课程教学的具体改革措施,重点分析了云教学法,以期能够提升课程教学的质量以及效率。     

大剂量甲孕酮治疗晚期乳腺癌23例分析

给２３例晚期乳腺癌患者单用大剂量甲孕酮：５００ｍｇ／次，前３ｄ２次／ｄ，以后为１次／ｄ，持续３０ｄ为一疗程。自觉症状改善者为８６％，近期客观有效率为６０．８％，以骨转移效果为佳。既往用三苯氧胺以及氨格鲁米特无效者再用大剂量甲孕酮仍分别有４／７及２／３的患者有效。副作用轻微，偶见阴道出血、向心性肥胖。     

ETC系统缴费方式随机选择模型

针对组合式收费系统中驾驶员缴费方式的随机选择行为,以排队论与非集计理论为基础,建立电子收费(Electronic Toll Collection,ETC)系统缴费方式随机选择模型及均衡状态求解算法。通过均衡分析与灵敏度分析探讨了ETC技术的采用对道路使用者的技术选择与车道选择行为所产生的影响,所得结果可为ETC系统的规划和管理提供帮助。     

EQ153汽车起动机转子总成焊接工艺

介绍了ＥＱ１５３汽车起动机转子总成原采用浸锡焊工艺，在使用过程中易发生转子甩锡，导致整机烧毁质量事故，为此，选择一种经济、合理、有效地技术对产品结构及工艺进行优化。     

恩丹西酮预防顺铂所致恶心呕吐31例报告

恩丹西酮预防顺铂所致恶心呕吐３１例报告肖菊香，李蓉，薛颖（西安第一临床医学院肿瘤医院内科西安７１００６１）恩丹西酮是山东齐鲁药厂生产的一种新型５ＨＴ３受体阻滞剂，具有很强的止吐作用。我院于１９９３年１月～１９９５年６月对３１例中晚期恶性肿瘤患者进行止...     

Research on pharmacokinetics of high-dose tamoxifen in non-small cell lung cancer patients

Objective To study the pharmacokinetics of tamoxifen at a high dosage, which will offer a theoretical support for an appropriate clinical use of the medicine in non-small cell lung cancer （NSCLC） patients. Methods Three qualified NSCLC patients are selected and given tamoxifen （TAM） 160 mg per Os. Blood samples were collected at different times and then analyzed by high-performance liguid chromatography. The PK-GRAPH program was used to obtain the parameters. Results The concentration-time courses of the TAM 160 mg were fitted to one-compartment model. The pharmacokinetic parameters were estimated as follows： Tmax （6. 35±1. 24）h, Cmax （217. 39±7. 71）ng/mL, AUC （12 127.39±636.16）ng · h/mL and T1/2ke（34. 13±2.97）h. Conclusion TAM 160mg one day per Os cannot reach the effective maintenance concentration in vivo required for reversing MDR in vitro. Loading-maintenance dose strategy is recommended to study the pharmacodynamies of tamoxifen at a high dosage in NSCLC patients.     

DIAGNOSTIC VALUE OF SERUM PROGRP31-98 IN PATIENTS WITH SMALL-CELL LUNG CANCER

Small celllungcancer (SCLC )isasubtyperepresentingapproximately 15 %to 2 0 %ofallpri marylungcarcinomaoccurringinChina .Ingener al,SCLCishighlysensitivetochemotherapyandhasafrequenttendencytometastasizeatanearlystage .Thus ,itisveryimportanttomakeanearlydiagnosisforthetreatmentofSCLC patients .NSEhaslongtermbeenusedasSCLCearlydiagnosismarkerinclinic[1] .However ,therelativelyhighfalse positiveratehasforcedthedoctorstolookforthemorespecificandsensitivemarker[2 ] .SincePro gastrin relea…     

Semi-supervised learning in large scale text categorization

The rapid development of the Internet brings a variety of original information including text information, audio information, etc. However, it is difficult to find the most useful knowledge rapidly and accurately because of its huge number. Automatic text classification technology based on machine learning can classify a large number of natural language documents into the corresponding subject categories according to its correct semantics. It is helpful to grasp the text information directly. By learning from a set of hand-labeled documents, we obtain the traditional supervised classifier for text categorization (TC). However, labeling all data by human is labor intensive and time consuming. To solve this problem, some scholars proposed a semi-supervised learning method to train classifier, but it is unfeasible for various kinds and great number of Web data since it still needs a part of hand-labeled data. In 2012, Li et al. invented a fully automatic categorization approach for text (FACT) based on supervised learning, where no manual labeling efforts are required. But automatically labeling all data can bring noise into experiment and cause the fact that the result cannot meet the accuracy requirement. We put forward a new idea that part of data with high accuracy can be automatically tagged based on the semantic of category name, then a semi-supervised way is taken to train classifier with both labeled and unlabeled data, and ultimately a precise classification of massive text data can be achieved. The empirical experiments show that the method outperforms the supervised support vector machine (SVM) in terms of both F1 performance and classification accuracy in most cases. It proves the effectiveness of the semi-supervised algorithm in automatic TC.     

非粉体纳米材料复合细颗粒掺合料对隧道衬砌混凝土性能影响的试验研究

隧道衬砌混凝土强度及耐久性能直接关系到工程的经济性和安全性.文章以安全、环保、经济及施工人性化为出发点,重点研究了以Ⅰ级粉煤灰配合辅助细颗粒材料微珠作为掺合料,单一或复合掺入不同种类、不同物理性态的纳米材料对胶砂试件强度的影响,对比分析非粉体纳米材料、粉体纳米材料、微硅粉应用于混凝土胶凝材料其物理力学性能,并对以非粉体纳米材料配合细颗粒复合掺合料作为胶凝材料的混凝土强度、耐久性能进行了试验研究.结果表明,非粉体纳米材料与复合掺合料复合应用于隧道衬砌混凝土具有经济、环保、耐久性好的优点,有推广应用前景.