Genome-wide profiling identifies Saccharomyces cerevisiae response in PKC-SLT2 signaling and glycogen metabolic pathways to antifungal compound calcofluor white

Fungal infection remains a major problem worldwide, yet treatment options are limited owing to the lack of effective drugs, the significant toxicity of available compounds, and the emergence of drug resistance. The low toxicity of calcofluor white （CFW） is an attractive antifungal compound for its known inhibitive effects on trichophyton rubrum and candida albicans growth. However, the efficacy of CFW is limited in most cases. In order to search for effective means to improve its efficacy, using saccharomyces cerevisiae as a model, we have used microarrays to examine the cell＇s response when treated with CFW on the genome scale. We found that both the PKC-SLT2 （i.e, protein kinase C-mitogen activated protein kinase） and the glycogen metabolic pathways are activated upon CFW treatment. These results suggest that the key components in these pathways could be targeted by other drugs to counter the cell＇s compensative response, thus to further substantiate the inhibitive effect of CFW on fungal growth, which may lead to treatment regimens with improved efficacy of this compound in clinical applications.     

ATO熔断片过渡端子的改进

车用电线束插接器端子是插接器电力和信号传输性能的关键零部件,其结构设计是决定连接器端子性能的一个重要因素。本文通过对原ATO熔断片过渡端子结构弊端的分析,优化设计一种新型的ATO熔断片过渡端子。     

磁流变液隔振器结构优化及仿真研究

分析磁流变液隔振器的工作原理,针对现有磁流变液隔振器高频时隔振能力较差的缺点进行结构优化,并通过示功特性进行仿真分析。仿真结果表明,改善后的隔振器流动性得到了提升,磁流变液隔振器在宽频范围内的循环耗散能量得到了增加,系统隔振性能得到提高。     

3GHz微波热声成像系统

为了评估3 GHz微波热声成像系统的性能,采用圆形扫描的探测方式,对不同形状、不同对比度以及埋在猪肉脂肪中不同深度处的仿体进行了热声成像实验.仿体实验结果表明,该系统对具有不同对比度的10 mm×20 mm的矩形吸收体、边长8 mm的正方形吸收体以及直径8 mm的圆形吸收体能够清晰地成像,系统的空间分辨率和成像深度分别为2和5 cm.      

软弱围岩隧道开挖方案优化研究

根据合福线合肥至福州段的万山隧道特点和隧道开挖施工现状,参考前期围岩变形、锚杆应力等监测成果,采用有限元方法分别模拟万山隧道Ⅴ级围岩六步CD法和三台阶七步法两种开挖方案,比较分析两种开挖方案下洞室应力、变形的数值结果,并结合结构安全、稳定情况,论证三台阶七步法施工方案的可行性和合理性。     

桥梁冬季施工的研究与探讨

结合桥梁冬季施工中存在的问题,对水泥水化热的影响和混凝土早期受冻的影响等问题进行详细介绍.以贵阳某桥段冬季施工为例,针对所出现的问题采取了材料保温与养护保温的改善措施,可为同类工程提供参考借鉴.     

Preparation and Characterization of the Covalent-Integrated Poly（lactic acid） and Scrap Leather Fiber Composites

Scrap leather fibers (SLFs) modified with active silane containing epoxide groups were incorporated into poly(lactic acid) (PLA) modified by vinyl trimethoxysilane, i.e., the PLA/SLF composites were prepared for bio-composites by solvent compounding technology in this article. The effects of silane coupling agents on the structures of PLA and SLF molecules were examined, and the mechanical properties and thermal stability of PLA/SLF composites were also measured. The results of Fourier-transform infrared spectroscopy (FTIR) had proved that silane had been incorporated successfully to PLA and SLF molecules by means of the solvent technology. Scanning electric microscopy (SEM) was used to investigate both the changes in shapes between the pristine SLFs and the treated SLFs and the microscopic structures of composites. According to SEM results, it was shown that there were some significant differences between the untreated and treated SLFs, and a double continuous phase structure had occurred in PLA/SLF composites due to the excellent dispersion of SLFs in matrix. The addition of the treated SLFs into PLA resulted in a distinct improvement of the impact and tensile strengths. When the mass fraction of the treated SLFs was 15%, the notched impact strength and tensile strength of PLA/SLF bio-composites were improved by 34.4% and 21.2% compared with the pristine PLA, respectively. Additionally, with the increase of the modified SLFs content, the thermal stability of PLA/SLF bi-composites was apparently improved. The macroscopic properties of bio-composites were found to be strongly dependent on their components, concentration, dispersion and resulted morphological structures.     

论沥青混凝土路面裂缝的产生原因及防治措施

对沥青混凝土路面裂缝产生的原因进行分析,提出相应的防治措施。     

天然气发动机怠速燃烧排放特性试验

在一台CNG发动机上研究怠速工况条件下,点火提前角(θi)和过量空气系数(λ)对燃烧排放性能的影响规律。节气门全关,参数调节时,步进电机自动调节,将发动机转速控制在800 r/min。θi在上止点前40～10°CA BTDC变化,λ=1.1时指示热效率和燃烧速度最高;随着λ增加,最高指示热效率所对应的θi越大;θi过大或过小,都会加剧循环变动;λ1.3,平均指示压力循环变动(CoVimep)明显增加;λ=1.1时,NOx排放最高。     

AutoCAD使用及二次开发

1 AutoCAD使用中的问题及解决方法AutoCAD作为设计行业的绘图软件,其操作简单易用,应用面之广泛在诸多软件中可以说是首屈一指的。AutoCAD版本也由原先AutoCAD R14升级至AutoCAD R2007,版本的升级带来了诸多新功能和便利,但是R14这