武汉阳逻长江大桥施工猫道设计与验算

扼要介绍了武汉阳逻长江大桥施工猫道的设计,采用ANSYS的LINK10与BEAM4单元计算了猫道这一柔性空间索桁结构在空索状态及成形状态的线形。在静力验算时,猫道中间标高处等效静阵风风速取为50.4m/s,由于主要承重结构钢丝绳弹性模量为索力的函数,本文参考国内多座桥梁施工猫道钢丝绳弹模实测值取用1.30×105MPa,按5种工况8种状态验算了猫道的静风稳定性验算。     

长大货物车适应THDS轴温探测技术的研究

针对不适应THDS轴温探测系统的长大货物车,分析论证了现车轴箱改进方案适应THDS轴温探测的不足,并提出了轴箱优化方案。经计算、试验和装车验证表明,新轴箱可行、有效、安全,满足THDS轴温探测要求,保证了长大货物车运输安全。     

集装箱专用平车加装承载板实现滚装运输技术研究

为弥补应急情况下滚装运输所需平车数量缺口,同时为完善车辆自身应急保障能力,分析集装箱专用平车用于滚装运输需求,针对集装箱专用平车用于滚装运输存在的主要问题,提出在不改变车体结构前提下,通过加装承载板实现滚装运输的解决思路。结合集装箱专用平车结构特点,分析承载板的数量、尺寸、材质,设计承载板由承载面、横支撑架、渡板、斜支腿、受力面、绳拴构成,给出加装改造方法,并通过校核承载能力和研究适运范围,研究加装改造后的集装箱专用平车滚装运输能力,得出改造后的集装箱专用平车可以满足大部分滚装运输货物运输需要。     

南海海区航标遥测遥控现状及未来发展的思考

文中对南海海区航标遥测系统现状和未来发展进行分析思考,提出建议,以期未来遥测遥控系统成为航标维护管理现代化的重要手段。     

CT reconstruction with priori MRI images through multi-group datasets expansion

Computed tomography (CT) reconstruction with a well-registered priori magnetic resonance imaging (MRI) image can improve reconstruction results with low-dose CT, because well-registered CT and MRI images have similar structures. However, in clinical settings, the CT image of patients does not always match the priori MRI image because of breathing and movement of patients during CT scanning. To improve the image quality in this case, multi-group datasets expansion is proposed in this paper. In our method, multi-group CT-MRI datasets are formed by expanding CT-MRI datasets. These expanded datasets can also be used by most existing CT-MRI algorithms and improve the reconstructed image quality when the CT image of a patient is not registered with the priori MRI image. In the experiments, we evaluate the performance of the algorithm by using multi-group CT-MRI datasets in several unregistered situations. Experiments show that when the CT and priori MRI images are not registered, the reconstruction results of using multi-group dataset expansion are better than those obtained without using the expansion.     

土压平衡盾构施工中泡沫改良砾砂土的试验研究

为了解决土压平衡盾构在砾砂土地层掘进过程中,土体塑流性差、刀盘及螺旋输送机磨损严重和开挖面平衡不易保持等问题,通过自制泡沫发生器发泡,对砾砂土地层的泡沫改良技术进行室内试验研究,分析气液比、含水率和泡沫掺量对塑流性的影响和改良前后土样的渗透系数的变化规律,得出泡沫发生器气液比在30∶1~55∶1、含水率为5%~12.5%、泡沫掺量为20%~40%时,土体具有较好的塑流性,泡沫的"轴承效应"和泡沫剂中表面活性剂的亲水基团与水、砾砂土颗粒形成的氢键是塑流性提高的根本原因;使用泡沫剂改良砾砂土后,渗透系数大幅降低,掺泡沫后在280 min内渗透系数随时间变化较小,能达到10~(-5)cm/s,泡沫剂溶液中高分子化合物的联结和液桥力是土样具有堵水作用的原因。     

降钙素基因相关肽与内皮素受体A在兔实验性蛛网膜下腔出血后基底动脉的表达

目的探讨蛛网膜下腔出血(SAH)后脑血管内皮细胞降钙素基因相关肽(CGRP)及内皮素受体A(ETRA)的表达与迟发性脑血管痉挛(DCVS)之间的关系。方法日本大耳白家兔60只,随机分为SAH模型组25只,盐水组25只,穿刺组5只,正常组5只。采用枕大池二次注血法制作SAH模型,灌注处死后取基底动脉制成切片。进行CGRP及ETRA的免疫组化和HE染色,观察CGRP与ETRA的免疫表达和病理结构变化,并用图像分析方法测量血管周长,使用方差分析进行统计学检验。结果基底动脉周长在SAH后均发生明显缩窄,其中在5d时缩小最强烈。CGRP与ETRA免疫阳性标记颗粒在SAH组的基底动脉组织中均有表达,其动态变化规律为CGRP的表达在1h时最明显,在3、5d依次表达减少,5d达到最低点,7d后开始逐渐升高,10d时表达相对比较明显,但未能达到正常水平,CGRP在穿刺组、正常对照组和盐水组也有散在不规则表达。在正常组、穿刺组和盐水组的基底动脉内ETRA有表达;SAH组基底动脉内ETRA在3d组和5d组表现为高表达,以3d组为强,而其中血管内皮细胞表达最强烈,平滑肌也有表达,10d组的表达仍然较强。结论在SAH后脑血管内皮细胞CGRP和ETRA的表达呈现明显的动态改变,但二者的变化趋势并不同步;CGRP和ETRA在DCVS的发生发展中起重要的作用。     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

客运站到发线运用优化研究

为了合理编制客运站到发线运用计划,作者确定了到发线均衡性评价标准,建立了既满足到发线固定使用方案,又达到均衡使用到发线的多目标二次0-1规划模型;并以德州东站为实例,利用LINGO软件进行了求解与验证。     

基于改进GA优化的水下机器人航向鲁棒控制

基于某型号水下机器人水平面线性化模型,针对水下机器人系统存在的多种不确定因素,工作环境复杂多变的问题,采用混合灵敏度法设计水下机器人航向鲁棒控制器。在设计中,通过罚函数小生境遗传适应度值作为桥梁建立起遗传寻优与混合灵敏度参数之间的关系,构成多目标优化问题寻优加权函数。实验结果表明,所用方法可在保证系统较强鲁棒性的同时,又能兼顾时域指标和混合灵敏度加权函数频域要求,获得综合性能指标最优的鲁棒控制器,控制效果较好。