车用柴油机电控开发系统的软,硬件设计及应用

本文研制了一种新的发动机电 控燃油系统的开发系统的微机测控系统。     

净化消声器压力损失计算方法

本文综合运用流体力学、热力学及化学有关理论,对柴油机用的净化消声器的压力损失算法进行推导及试验验证,为在净化消声器设计阶段预测净化消声器对发动机性能的影响提供了可用的手段。     

软土地层中暗挖轨道交通车站设计方案探讨

为解决上海城市发展与轨道交通建设之间矛盾,提出了针对软土地层中用暗挖法建轨道交通车站的设计前提、方法、内容。重点对用盾构法修建明、暗结合型式,全暗挖,地上、地下配合的轨道交通车站设计进行了初步探讨,以期促进软土地层中暗埋轨道交通车站技术的发展。     

轨道交通信号控制系统LCC估算方法研究与应用

从产品全生命周期成本概念出发,阐述了轨道交通信号控制系统生命周期的特点和成本构成;从企业视角提出了一种轨道交通信号控制系统的LCC估算方法;通过企业项目成本管理信息化系统统计产晶LCC的各项数据,结合财务数据进行归一化估算,并定期进行回归迭代,规范化实施分析与评价,从而得出产話的LCC改进建议,为公司战略决策提供了重要参考依据。     

地铁供电系统中压开关柜电流分析理论和方法

通过分析地铁供电系统不同电压等级的设备电流特征,确定35 kV电压等级设备电流可构造标准曲线,采用机器智能学习算法分析、测算地铁供电系统中各类开关峰谷时段运行电流,以均值-方差方法确定电流的高度异常偏离点,实现异常点数据周期内统计以及实时提醒功能。应用电流实测值分析电流在工作日、节假日的不同曲线,为负荷预测和非正常运行方式下的负荷叠加风险提供预测和评估依据,保障供电系统的安全运行,提高负荷管控效率。     

A proposed vision and vehicle-to-infrastructure communication-based vehicle positioning approach

It is essential to obtain accurate location of vehicles for new applications of Intelligent Transportation Systems. To remedy the defects of present Global Positioning System and vehicle-to-infrastructure (V-I) positioning technology, a new positioning approach based on vision and V-I communication is proposed. This approach aims at lane-level positioning with lower cost than conventional ones. In this approach, the position of the vehicle is represented by its lateral position (the lane number) and longitudinal position (the distance from entrance of the road) in a course coordinate system along the road; the specific lane the vehicle is occupying (the lane number) can be judged using the information of lane lines detected by vision systems; then the distance to the vehicle is obtained by a Road Side Unit (RSU) during the V-I communication; and the longitudinal position is calculated. The error of the approach on typical operating conditions is analyzed, indicating that the new approach can achieve the accuracy of less than 0.31 m for straight road and 0.58 m for typical arc road with ultra-wideband communication and ranging technologies and rational arrangement of RSUs. The feasibility of this approach is presented.     

新加坡公共交通发展经验及启示

通过实际考察和走访咨询,系统地总结了新加坡的公共交通发展经验。首先介绍了新加坡对小汽车和公共交通发展采取的＂推、拉策略＂,以及新加坡公共交通的发展历程。在此基础上,对新加坡公共交通发展的成功经验进行了归纳和总结,包括管理机制、公共交通设施建设、公共交通运营系统、政策法规等方面的内容。结合我国城市交通发展的现状和特点,对城市公共交通的发展提出了措施和建议。     

快速老化小鼠的学习记忆缺陷及其生化机制

目的用快速老化小鼠(SAMP8)模拟老年痴呆,观察其学习记忆能力,并探讨其学习记忆能力下降的可能机制。方法采用10月龄SAMP8,并用同龄抗快速老化小鼠(SAMR1)作为正常对照。用水迷路检测近记忆以及空间学习记忆能力。用生物化学方法检测大脑皮层线粒体膜电位和ATP酶活力,观察线粒体功能;检测皮层和海马胆碱乙酰基转移酶(ChAT)和乙酰胆碱酯酶(AChE)的活力,观察中枢胆碱能神经功能;检测血清超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量,观察其全身性氧化应激状况。结果与SAMR1相比,SAMP8出现明显的衰老体征,其近记忆和空间学习记忆能力明显减弱,具有衰老和痴呆特征;皮层线粒体膜电位和ATP酶活力显著降低,海马ChAT活力显著下降,AChE活力显著升高,血清SOD活力稍有增高。结论SAMP8可以很好地模拟老年痴呆,其机制包括大脑皮层线粒体功能降低、海马胆碱能神经功能下降以及氧化应激等。     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.