Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响

目的观察沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响。方法实验用深部X线治疗机,每次以3000 cGy的剂量,照射两次,造成大白鼠臀部放射性皮肤损伤。待动物症状明显后,将Ⅱ度皮肤损伤的动物随机分为6组,即阴性对照组、沙棘果油高剂量组、沙棘果油低剂量组、沙棘籽油高剂量组、沙棘籽油低剂量组以及阳性对照组。沙棘果油及籽油高剂量组,每天在损伤部位涂药两次,而其低剂量组每天涂药一次,阴性对照组每天涂灭菌的注射用水一次,阳性对照组每天涂Solcoseryl-Jelly软膏一次。结果肉眼观察结果显示,连续用药10d后,沙棘果油、籽油及Sol-coseryl-Jelly组动物的局部红斑、水肿明显减轻,创面分泌物明显减少,用药2周后,上述症状明显消退,与阴性对照组比较,明显好转;另外,沙棘果油、籽油及Solcoseryl-Jelly组的创面愈合时间明显缩短。光学显微镜观察结果显示,沙棘果油、籽油及Solcoseryl-Jelly组的皮肤损伤明显减轻,炎症反应亦明显减轻,创面修复明显。电子显微镜观察结果显示,阴性对照组的超微结构明显受损,而沙棘果油、籽油及Solcoseryl-Jelly组的损伤明显减轻。结论沙棘果油及沙棘籽油对大鼠放射性皮肤损伤有明显的治疗作用。     

护栏高度变化对防撞能力影响研究

护栏高度由于路面加铺罩面而降低,使得其安全防护性能受到影响。利用LS-DYNA有限元分析软件对不同高度下波形梁护栏进行了碰撞仿真实验,量化分析了护栏高度降低与其安全防护能力关系,确定了护栏防撞性能不能满足规范要求的临界高度值。对沿海高速公路原有护栏提出改造方案,并运用计算机仿真证明其符合规范规定。     

我国载人深渊器的发展策略及当前进展

文中简要介绍了载人深渊器的概念;阐述了我国研制载人深渊器的意义;总结了"蛟龙号"的经验与启示;提出了我国载人深渊器的发展策略并综述了目前所取得的进展.     

安装中央制动器的某型变速器的后壳体设计与开发

针对某型变速器后壳体进行改型设计,增加了安装中央制动器的结构,对改型设计及加强设计的后壳体进行了有限元分析计算、台架试验和道路试验。计算及试验表明,加强设计的后壳体强度完全满足使用要求,此状态的后壳体已进入批量生产阶段。     

短时段交通流预测的RBF神经网络模型

介绍了基于RBF神经网络的短时段交通量预测模型,并利用该模型对高速公路所采集的数据进行仿真预测分析。预测结果表明RBF神经网络预测方法通过定义合理的网络结构参数可以获得较高的预测精度,能够满足路网调度对短时段交通流预测的需求。     

现浇支架和悬浇挂篮预压技术措施探讨

分析了现浇支架和悬浇挂篮预压的特点,结合工程实例,介绍了现浇支架和悬浇挂篮预压的几种方法,总结了预压过程中的控制要点。     

公路网络与区域发展协调研究

采用系统分析方法，通过目标分解分别建立公路网络和区域社会经济发展的供给与需求水平评价指标体系，定义综合评价函数、协调度、协调变化趋势指数等协调发展动态评价模型，并对协调程度的综合判断、发展趋势进行分析。     

电控空气悬架载荷平衡系统仿真

结合当代最新设计理念,利用MATLAB和ADAMS/Car软件的联合仿真,设计了电控空气悬架载荷平衡系统,并对整体系统进行了几个工况的模拟仿真。结果表明:所设计的空气悬架载荷平衡系统性能良好;联合MATLAB和ADAMS软件的长处来设计系统,能够使产品开发过程加快,同时产品开发成本也相应下降。     

地铁盾构隧道施工对周边环境影响的监测

地铁盾构隧道在通过不良地质条件地段施工过程中会对地层产生扰动,可能引起地表及周边建筑物变形或沉降,尤其是隧道穿过正在施工的基坑止水幕墙时,可能会拉裂幕墙危及基坑及附近建筑物安全,因此必须进行监测。文章介绍了广州地铁盾构隧道施工过程中的第三方监测的经验和体会,可供同类工程施工中借鉴。