THE CYTOTOXIC EFFECTS OF CRUDE BILE ON HUMAN PANCREATIC CANCER CELL LINES

Thebileacidswereconfirmedasnonspecificcytotoxicsubstanceswhichplayveryimportantro1einpathophysiologyofextrahepaticcholesta-sis[la.Invitrostudieshadprovedthatthebileacidscouldcausechronicandacuteinjuryofpancreaticductalepitheliumactingasaninitiatorofpancre-atitist2i.Thepancreaticcancerisamajorworld-widepublichealthproblernandremainsasignifi-cantclinica1challenge.Atthetimeofdiagnosis,about7o%ofpancreaticcancerpatientsmanifestobstructivejaundicewhichcanresultinprogressiveliverdysfunctionandculmin…     

ANALYSIS OF PSYCHOLOGIC HEALTH STATE AND INFLUENCING FACTORS IN COLLEGE AND SECONDARY SCHOOL STUDENTS IN SHAANXI PROVINCE

It is necessary for educationists to knowstudents psychologic health state in colleges andmiddle schools.In recent years,there are lots of in-vestigations and researches on students psycholog-ic health state in colleges and middle schools.Re-sults have shown thatthe percentage ofcollege andmiddle school students psychologic disorder is be-tween1 0 and30 [1～ 5] .Shaanxi province lies in theNorthwestof China,thus its economics is compara-tively less developed.And also,there are lots ofcolleges…     

前风挡玻璃粘接安全宽度计算

给出用于指导玻璃粘接的胶粘剂粘接宽度的公式及粘接厚度、接缝密封宽度的相应图表。     

供应链管理环境下的VMI管理系统

在供应链管理的环境下,供应链的各个环节的活动都应该是同步进行的,而传统的库存控制方法无法满足这一要求。供应商管理用户库存(Vendor Man- agement Inventory,简称VMI)打破了传统的各自为政的库存管理模式,体现了供应链的集成化管理思想,适应市场的要求,是一种新的有代表性的库存管理思想。     

四跨一联预应力混凝土连续宽箱梁空间分析

结合上海市中环线虹梅路立交工程对主线四跨一联预应力混凝土连续宽箱梁进行空间分析,得到结构在荷载作用下的剪力滞效应分布规律、截面实际中性轴与平截面假定中性轴的比较、偏载下支座反力的分布规律、挑臂横向挠度、偏载下的偏载系数以及增设跨中横隔板与否对结构受力状态的影响等结论。     

悬索桥岩锚式锚碇的承载特性研究

悬索桥岩锚锚碇系统能充分利用岩体承载能力, 但至今工程案例较少, 为了研究其承载特性和破坏模式, 以主跨为 1768m 的某公路双塔单跨吊钢箱梁悬索桥岩锚锚碇为背景, 首先建立了锚址区地质概化模型, 通过原位测试和室内试验分析得到岩体力学特性。 然后, 采用 FLAC3D 建立了锚碇系统及围岩相互作用的三维模型, 模拟分析了岩锚区围岩塑性区分布规律、 变形特征、 岩锚破坏模式。 最后, 采用楔形断裂法得到了岩锚的抗拔安全系数。 得出结论如下: (1) 岩锚锚碇系统的破坏机理为主缆拉力作用下, 锚体及周边围岩沿着破裂角发生整体拉剪复合破坏; (2) 通过超载法得到该桥岩锚锚碇围岩稳定安全系数为 7. 0; (3) 采用 “楔形断裂法” 得到岩锚锚碇的抗拔安全系数为 4. 0。     

土工格栅砂垫层与碎石桩复合地基承载试验研究

单独使用碎石桩复合地基在提高软土地基承载力和减小变形方面效果较差.通过模型试验对土工格栅加筋砂垫层 碎石桩复合地基处理软弱地基进行了研究,在大量试验数据的基础上,对其承载机理和抗变形能力进行了较为详尽的理论分析,试验结果表明,土工格栅砂垫层 碎石桩复合地基能大幅度提高软弱地基的承载能力,且桩顶布置的土工格栅加筋垫层能够有效地分散荷载,减少地基沉降量.     

不同锚具锚固效果及最佳限位距离研究

为解决公路隧道中采用预应力锚索支护时如何选择合适锚具及其最佳限位距离的问题,选用A、B、C 3类常见矿用锚具,通过理论分析、室内试验以及现场试验的方法,探究3类锚具锚固效果及与之对应的最佳限位距离。结果表明： 1）预应力损失与限位距离存在慢速下降、快速下降和稳定损失3个阶段,拐点x2为锚具的理论最佳限位距离; 2）根据锚具结构、相同限位距离下预应力损失情况和锚具张拉前后的回缩长度综合得出,在相同的条件下,B型锚具的锚固效果优于A型和C型; 3）锚具的实际最佳限位距离应低于理论最佳限位距离和锚索张拉前夹片平均外露长度,则对于最佳限位距离A型锚具为12.0 mm,B型锚具为10.0 mm,C型锚具为13.0 mm。     

Mass transit systems of Beijing: governance evolution and analysis

Developing a more efficient mass transit system, in highly populated cities, improves the mobility, decreases the dependency of private cars, alleviates traffic congestion, and provides a more environmentally friendly means of travel. Recently, the city of Beijing decided to have a target of becoming as a ‘public-transport city’ with a fascinating mass transit system within a larger plan, of building humanistic, scientific and technological, and green public-transport systems. This work discusses the governance evolution of the mass transit system of Beijing between 1949–2008, comprised of two groups of transit systems, the road surface public-transport system (bus, tram, trolley, etc.), and the subway public-transport system. In addition, a time-series analysis is introduced in an attempt to examine the effect of governance evolution on the two transit systems, and of the impacts of the governance structural changes on the mass transit system. The time-series model is introduced using the annual statistics data of the period 1949–2008. The outcome of the analysis is viewed with precaution because of the incompleteness of the many endogenous and exogenous factors to affect the public-transport demand. Generally speaking it is concluded that the governance evolution provides beneficial effect of the Beijing mass transit activity; however, for satisfying the significant increase of the Beijing city’s travel demand and maintaining sustainable development, the governance-involvement pattern needs to be reformed.     

Hybrid model for prediction of bus arrival times at next station

Effective prediction of bus arrival times is important to advanced traveler information systems (ATIS). Here a hybrid model, based on support vector machine (SVM) and Kalman filtering technique, is presented to predict bus arrival times. In the model, the SVM model predicts the baseline travel times on the basic of historical trips occurring data at given time‐of‐day, weather conditions, route segment, the travel times on the current segment, and the latest travel times on the predicted segment; the Kalman filtering‐based dynamic algorithm uses the latest bus arrival information, together with estimated baseline travel times, to predict arrival times at the next point. The predicted bus arrival times are examined by data of bus no. 7 in a satellite town of Dalian in China. Results show that the hybrid model proposed in this paper is feasible and applicable in bus arrival time forecasting area, and generally provides better performance than artificial neural network (ANN)–based methods. Copyright © 2010 John Wiley & Sons, Ltd.